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| 1 | Climate Change, Risk and Grain Yields in China显示文摘Adopting Just and Pope (1978, 1979) style yield functions, this paper proposes a method to analyze the impacts of regional climate change on grain production in China. We find that changes in climate will affect grain production in North and South China differently. Specifically, it emerges that a 1℃ increase in annual average temperature could reduce national grain output by 1.45% (1.74% reduction in North China and 1.19% reduction in South China), while an increase in total annual precipitation of around 100 mm could increase national grain output by 1.31% (3.0% increase in North China and 0.59% reduction in South China). | Rainer Holst Xiaohua Yu Carola Grün | 2013 | Journal of Integrative Agriculture2013，12，7： | 14 |
| 2 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 3 | Grp78 is involved in retention of mutant low density lipoprotein receptor protein in the endoplasmic reticulum显示文摘 | Jrgensen M M Jensen O N Holst H U | 2000 | J Biol Chem2000，275，33： | 1 |
| 4 | Field weed population dynamics:a review of model approaches and applications显示文摘 | Holst N Rasmussen I A Bastiaans L | 2007 | Weed Research2007，47，： | 1 |
| 5 | Degradation of microcystin in sediments at oxic and anoxic denitrifying conditions 显示文摘 | Holst T Jorgensen N O G Jorgensen C | 2003 | Water Res2003，37，19： | 1 |
| 6 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O' Connor S M van Holst Pellekaan N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 7 | Field weed population dynamics:a review of model approaches and applications显示文摘 | HOLST N RASMUSSEN IA BASTIAANS L | 2007 | Weed Research2007，47，： | 1 |
| 8 | Enteral feeding without pancreatic stimulation显示文摘 | Kaushik N Pietraszewski M Holst J J | 2005 | Pancreas2005，31，4： | 1 |
| 9 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O′ C S van Holst P N | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 10 | Enteral feeding without pancreatic stimulationl 显示文摘 | Kaushik N Pietraszewski M Holst J J | 2005 | Pancreas2005，31，4： | 1 |
| 11 | GLP-1 and GLP-2 act in concert to inhibit fasted,but not fed,small bowel motility in the rat显示文摘 | Bozkurt A Nslund E Holst JJ | 2002 | Regul Pept2002，107，13： | 1 |
| 12 | EGF stimulates at spermatogonial DNA synthesis in seminiferous tubule segments in vitro显示文摘 | Wahlgen A Martinelle N Holst M | 2003 | Mol Cell Endocrinol2003，201，1： | 1 |
| 13 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z SM O C van Holst Pel ekaan N G | | 0，，12： | 1 |
| 14 | EGF stimulates rat spermatogonial DNA synthesis in seminiferous tubule segments in vitro显示文摘 | Wahab-Wahlgren A Martinelle N Holst M | 2003 | Mol Cell Endocrinol2003，201，12： | 1 |
| 15 | Extracellular Signal-regulated kinases are involved in the acute activation of steroidogenesis in immature rat leydig cells by human chorionic gonadotropin显示文摘 | Martinelle N Holst M Soder O etal | 2004 | Endocrinology2004，145，10： | 1 |
| 16 | Influence of organic and ammonia loading on nitrification performance for a twostage biological aerated filter system显示文摘 | Gilmore K R Husovitz K J Holst T Love N G | 1999 | Wat Sci Tech1999，39，7： | 1 |
| 17 | Assessment of the cover effect in trawl codend selectivity experiments显示文摘 | Madsen N Holst R | 2002 | Fisheries Research2002，56，： | 1 |
| 18 | Recursive forgetting algorithms显示文摘 | Parkum J E Poulsen N K and Holst J | 1992 | International Journal of Control1992，55，1： | 1 |
| 19 | Reduced accumulation of specific microRNAs in colorectal neoplasia显示文摘 | Michael M Z O'Connor S M van Holst Pellekaan N G | 2003 | Mol Cancer Res2003，1，12： | 1 |
| 20 | Metformin asso- ciated with lactic acidosis in treatment of type 2 diabetes 显示文摘 | HOLST H ELDRUP E GULDSTAD N H | 2012 | Ugeskr Laeger2012，174，23： | 1 |
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