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| 1 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 2 | 认知方式问卷中文版在大学生中的试用显示文摘目的:建立认知方式问卷(CSQ)中文版,并分析信效度。方法:按量表翻译程序将CSQ翻译成中文,选取647名大学生进行CSQ中文版的测量。随机抽取其中130名大学生于初评后1个月进行重测,并与功能失调态度问卷(DAS)比较,评估与抑郁症状的相关性。结果:CSQ中文版共72个条目,分为评估原因、评估结果、评估自我认知及评估内在归因4个维度;总量表的Cronbachα系数为0.95,重测信度为0.82,各分量表的α系数在0.71~0.80之间;条目间平均相关系数在0.24~0.42之间。验证性因子分析显示数据拟合良好(GFI=0.90,CFI=0.92,IFI=0.91,RMSEA=0.07)。4个因子间标准路径数为0.47~0.98,因子内部标准路径系数0.60~0.91。CSQ单独及与DAS一起进入回归都对抑郁症状有显著相关((β=0.22,0.20,均P<0.01),而DAS只单独进入时对抑郁症状有显著相关性(β=0.15,P<0.01)。结论:认知方式问卷中文版具有良好的信效度。与功能失调态度问卷比较,认知方式问卷中文版与抑郁症状的相关性可能更高。 | 邹涛 姚树桥 朱熊兆 ABELA John RZ AUERBACH Randy P | 2012 | 中国心理卫生杂志2012，26，2： | 7 |
| 3 | Particulate air pollution and daily mortality on Utah's wasatch front 显示文摘 | Arden P C Randy W H Martin G V | 1999 | Environmental Health Perspectives1999，107，7： | 1 |
| 4 | Enhanced external counterpulsation for ischemic heart disease:a look behind the curtain 显示文摘 | Randy W Darren P Darren T | 2012 | Exerc Sport Sci Rev2012，40，3： | 1 |
| 5 | Uroguanylin: how the gut got another satiety hormone显示文摘 | Seeley Randy J Tsch?p Matthias H | 2011 | Journal of Clinical Investigation2011，，9： | 1 |
| 6 | Aerial color infrared photography for determining late season nitrogen requirements in corn显示文摘 | Sripada R P Tteiniger R W White J G Randy W | 2005 | Agronomy Journal2005，97，： | 1 |
| 7 | Severin Elemental distibution within polymorphic inconnu(Stenodus leucichthys) otoliths is affected by crystal structure显示文摘 | Randy Brown Kenneth P | 1999 | Can J fish Aquat Sci1999，56，10： | 1 |
| 8 | Exploring process data with the use of robust outlier detection algorithms显示文摘 | LEO H C RANDY J P MARY B S | 2003 | Journal of Process Control2003，，13： | 1 |
| 9 | Pediatric CT Sedation:Comparison of Dexmedetomidine and Pentobarbital显示文摘 | Mason KP Randy P Fontaine PJ | 2011 | AJR Am J Roentgenol2011，196，2： | 1 |
| 10 | Aerial color infrared photography for determining late season nitrogen requirements in corn 显示文摘 | Srlpada R P Tteiniger R W White J G Randy W | 2005 | Agronomy Journal2005，97，： | 1 |
| 11 | Potential applications of phase change materials in concrete technology显示文摘 | Dale P Randy T | 2007 | Cem Concr Compos2007，29，： | 1 |
| 12 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 13 | Occupational Segregation by Race and Gender, 1958-1981显示文摘 | Randy P A | 1986 | Industrial and LaborRelations Review1986，，3： | 1 |
| 14 | Pediatric CT Sedation:Comparison of Dexmedetomidine and Pentobarbital 显示文摘 | Mason KP Randy P Fontaine PJ | 2011 | AJR AM J Roentgenol2011，196，2： | 1 |
| 15 | Acute coronary diaease in essential thrombocythemia and polycythemia vera 显示文摘 | Rossi C Randi ML Zerbinati P | 1998 | J Intern Med1998，244，： | 1 |
| 16 | Effects of image compression on iris recognition system performance显示文摘 | Robert W I Randy P B Lauren R K | 2008 | Journal of Electronic Imaging2008，17，01： | 1 |
| 17 | Fermentative produc- tion of lactic acid from biomass: an overview on process developments and future perspectives显示文摘 | ROJAN P J NAMPOOTHIRI K M RANDY A | 2007 | Appl Microbiol Biotechnol2007，74，3： | 1 |
| 18 | A method for judicious fusion of inconsistent multiple sensor data显示文摘 | Manish Kumar Devendra P Garg Randy A Zachery | 2007 | IEEE Sensors Journal2007，，5： | 1 |
| 19 | Estimating three-dimensional rock discontinuity orientation from digital images of fracture traces显示文摘 | Kemeny J Randy P | 2003 | Computers & Geosciences2003，29，1： | 1 |
| 20 | Potential applications of phase change materials in concrete technology 显示文摘 | DALE P RANDY T | 2007 | Cem Concr Compos2007，，29： | 1 |
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