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| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | Developing Additive Technology for Wet Dual Clutch Transmissions显示文摘Wet dual clutch transmissions(W-DCTs) show overall benefits including excellent fuel efficiency,wide torque capacity range,long durability,driving comfort and sportiness.Many breakthroughs have been made to further improve the fuel efficiency by design innovations and introductions of new hardware.Each W-DCT has its unique design and hardware.It demands the lubricant to provide excellent wet clutch friction performance and anti-shudder friction durability,good synchronizer friction performance and durability,high load-carrying ability,excellent bearing performance,strong anti-corrosion performance,high thermal and oxidative stability,excellent material compatibility,etc.Particularly,the requirement of the wet clutch friction performance in W-DCT is much more severe than conventional ATFs and CVTFs.We report here our latest W-DCTF technologies developed for different W-DCT applications.DCTF-1 was optimized for a two-sump W-DCT application with the clutch lining material of friction material A(FM-A).DCTF-1 shows high and stable dynamic friction,static friction,particularly,high quasi-static friction without any shudder tendency in GK tests.DCTF-2 was designed for a one-sump W-DCT application with the same clutch lining material of FM-A.DCTF-2 completes 42,000 cycles of the severe GTI chassis dynamometer vehicle test without any issues,which is comparable to the factory fill fluid DCTF-FF.DCTF-3 was developed for a one-sump W-DCT application with a different clutch lining material of FM-B.DCTF-3 shows high and stable dynamic friction in the severe newly developed SAE DCT test procedure.DCTF-3 also gives excellent LVFA durability of over 720 h in the JASO M349 test procedure on FM-B. | Hong-Zhi Tang Ramnath Iyer Samuel H.Tersigni Philippe Ezanno Christopher S.Cleveland | 2012 | 润滑油2012，27，2： | 2 |
| 3 | High-level resistance to class lIa bacteriocins is associated with one general mechanism inListeria monocytogenes 显示文摘 | Gravesen A Ramnath M Knochel S | 2002 | Microbiology2002，148，： | 1 |
| 4 | Henoch-Schonlein purpura in children: An epidemiological study among Dutch paediatricians on incidence and diagnostic criteria显示文摘 | Aalberse J Dolman K Ramnath G | 2007 | Ann Rheum Dis2007，66，12： | 1 |
| 5 | Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry 显示文摘 | Deeb G Wang J Ramnath N | 2004 | Mod Pathol2004，17，4： | 1 |
| 6 | Multi-view AAM fittingand construction 显示文摘 | RAMNATH K KOTERBA S XIAO J | 2008 | International Journal of Computer Vision2008，76，2： | 1 |
| 7 | Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx显示文摘 | Singh A Ramnath RD Foster RR | 2013 | PLoS One2013，8，2： | 1 |
| 8 | Investor and Analyst Reactions to Earnings Announcements of Related Firms: An Empirical Analysis显示文摘 | Ramnath Sundaresh | 2002 | Journal of Accounting Research2002，，40： | 1 |
| 9 | Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer显示文摘 | Aljada IS Ramnath N Donohue K | 2004 | J Clin Oncol2004，22，16： | 1 |
| 10 | Prognostic significance of MCM2,Ki-67 and gelsolin in non-small cell lung cancer显示文摘 | Yang J Ramnath N Moysich KB et a1 | 2006 | BMC Cancer2006，6，： | 1 |
| 11 | Matrix metalloproteinase inhibitors显示文摘 | Ramnath N Creaven P J | 2004 | Curr Oncol Rep2004，6，2： | 1 |
| 12 | Effect of abrin on cell-mediated immune responses in mice显示文摘 | Ramnath V Kuttan G Kuttan R | 2006 | Immunopharmacol Immunotoxicol2006，28，2： | 1 |
| 13 | High su- peroxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis 显示文摘 | Park EM Ramnath N Yang GY | 2007 | Free Raclic Biol Med2007，42，2： | 1 |
| 14 | MR appearance of SONK-like subchondral abnormalities in the adult knee:SONK redefined显示文摘 | Ramnath RR Kattapuram SV | 2004 | Skeletal Radiol2004，33，10： | 1 |
| 15 | MCM2 is an independent predictor of survival in patients with non - small - cell lung eancer显示文摘 | Nithya Ramnath Francisco J Hernandez | 2001 | J Clin Oncol2001，19，： | 1 |
| 16 | Muhi-view AAM fitting and construction 显示文摘 | Ramnath K Koterba S Xiao J | 2008 | International Journal of Computer Vision2008，76，2： | 1 |
| 17 | Remote diagnosis design for a PLC - based automated system : 1 - implementation of three levels of architectures 显示文摘 | Ramnath Sekar Sheng- Jen Hsieh Zhenhua Wu | 2011 | Internationai Journal of Advanced Manufac- turing Technology2011，57，58： | 1 |
| 18 | Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils显示文摘 | Sun J Ramnath RD Bhatia M | 2007 | Am J Physiol Cell Physiol2007，293，2： | 1 |
| 19 | Retinoids and apoptosis in cancer therapy 显示文摘 | Kalemkerian SM Ramnath N | 1996 | Apoptosis1996，18，9： | 1 |
| 20 | Characterization and performance of plasma sprayed WCCocoatings 显示文摘 | RAMNATH V JARAYAMAN N | 1989 | Mater Sci Technol1989，5，： | 1 |
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