|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage Ⅲ nonsmall cell lung cancer显示文摘AIM: To prospectively determine the safety and tolerability of oral L-selenomethionine(SLM) with concurrent chemoradiation(CCRT) for Stage Ⅲ non-small cell lung cancer(NSCLC) and estimate if the incidence and/or severity of adverse events could be reduced by its use.METHODS: Sixteen patients with stage Ⅲ NSCLC were accrued to this single arm, phase Ⅱ study. CCRT consisted of radiation given at 2 Gy per fraction for 30-33 fractions, 5 d per week with concurrent weekly Ⅳ paclitaxel 50 mg/m2 followed by carboplatin dosed at an area under the time-concentration curve of 2. SLM was dosed in a loading phase at 4800 μg twice daily for one week prior to CCRT followed by once daily dosing during treatment. RESULTS: No selenium-related toxicity was observed. Analysis revealed grade 3 or higher esophagitis in 3 of 16 patients(19%), pneumonitis in 0, leukopenia in 2(12.5%), and anemia in 1(6%); the latter two were significantly reduced when compared to the protocolstated expected rate of 35%(P = 0.045 for leukopenia, and P < 0.01 for anemia). Median overall survival was 14.9 mo and median failure-free survival was 9 mo(95%CI: 3.3-21.5).CONCLUSION: There may be some protective benefit of selenium in the setting of CCRT for inoperable NSCLC. The data suggests decreased rates of myelosuppression when compared to similarly-treated historical and contemporary controls. Further evaluation of selenium in this setting may be warranted. | Michael Mix Nithya Ramnath Jorge Gomez Charles de Groot Saju Rajan Shiva Dibaj Wei Tan Youcef Rustum Michael B Jameson Anurag K Singh | 2015 | World Journal of Clinical Oncology2015，6，5： | 4 |
| 2 | Henoch-Schonlein purpura in children: An epidemiological study among Dutch paediatricians on incidence and diagnostic criteria显示文摘 | Aalberse J Dolman K Ramnath G | 2007 | Ann Rheum Dis2007，66，12： | 1 |
| 3 | Multi-view AAM fittingand construction 显示文摘 | RAMNATH K KOTERBA S XIAO J | 2008 | International Journal of Computer Vision2008，76，2： | 1 |
| 4 | Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer显示文摘 | Aljada IS Ramnath N Donohue K | 2004 | J Clin Oncol2004，22，16： | 1 |
| 5 | Muhi-view AAM fitting and construction 显示文摘 | Ramnath K Koterba S Xiao J | 2008 | International Journal of Computer Vision2008，76，2： | 1 |
| 6 | Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer显示文摘 | Aljada IS Ramnath N Donohue K | 2004 | J Clin Oncol2004，22，16： | 1 |
| 7 | Henoch-SchOnlein purpura in children:an epidemiological study among Dutch paediatricians on incidence and diagnostic criteria 显示文摘 | Aalberse J Dolman K Ramnath G | 2007 | Ann Rheum Dis2007，66，： | 1 |
| 8 | Chronic exposure tolaminar shear stress induces Kruppel-like factor 2 in glomerularendothelial cells and modulates interactions with co-culturedpodocytes 显示文摘 | Slater SC Ramnath RD Uttridge K | 2012 | UBB2012，44，9： | 1 |
| 9 | Henoch-Schtinlein purpura in children: an epidemiological study among Dutch paediatricians on incidence and diagnostic criteria 显示文摘 | Aalberse J Dolman K Ramnath G | 2007 | Ann Rheum Dis2007，66，12： | 1 |
| 10 | Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer显示文摘 | Aljada IS Ramnath N Donohue K | 2004 | J Clin Oncol2004，22，16： | 1 |
| 11 | Prognostic significance of MCM2,Ki-67 and gelsolin in non-small cell lung cancer显示文摘 | Yang J Ramnath N Moysich K B | 2006 | BMC Cancer2006，6，： | 1 |
| 12 | Behavioral effects of parasitism in animals显示文摘 | Ramnath K M N | 2009 | Journal of Exotic Pet Medicine2009，18，4： | 1 |
| 13 | Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer 显示文摘 | JUN Y RAMNATH N MOYSICH K B | 2006 | BMC Cancer2006，6，： | 1 |
| 14 | Kleine-Levin syndrome显示文摘 | Ramnath B Kalaniti K | 2008 | Indian Pediatr2008，45，12： | 1 |
| 15 | Absence of a putative mannose-specific phosphotransferase system enzyme IIAB component in a leucocin A-resistant strain of Listeria monocytogenes, as shown by two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis显示文摘 | Ramnath M Beukes M Tamura K | 2000 | Appl Environ Microbiol2000，66，： | 1 |
| 16 | Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small cell lung cancer显示文摘 | Aljada IS Ramnath N Donohue K | 2004 | J Clin Oncol2004，22，16： | 1 |
| 17 | Absence of a Pu- tative Mannose-specific Phosphotransferase System Enzyme IIAB Component in a Leucocin A-resistant Strain of Listeria monocytogenes, as Shown by Two-dimemional Sodium Dodecyl Sulfate-polyacrylamide Gel Electrophoresis显示文摘 | RAMNATH M BEUKES M TAMUR_A K | 2000 | Applied and Environmental Microbiology2000，66，7： | 1 |
| 18 | Pachyo- nychia congenita with unusual features 显示文摘 | Balasubramanian S Kaarthigeyan K Ramnath B | 2009 | Indian Pediatr2009，46，10： | 1 |
| 19 | Absence of a Putative Mannose-Specific Phosphotransferase System Enzyme IIAB Component in a Leucocin A -Resistant Strain of Listeria Monocytogenes, as Shown by Two-Dimensional Sodium Dodecyl Sulfate -Polyarcylamide Gel Electrophoresis 显示文摘 | RAMNATH M BEUKES M TAMURA K | | Applied and Envirmmmnt Microbiology0，66，7： | 1 |
| 20 | Amelioration of heat stress induced disturbances of antioxidant defense system in chicken by Brahma Rasayana 显示文摘 | RAMNATH V REKHA P S SUJATHA K S | 2008 | Evidence Based Complement Altern Medicine2008，5，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员