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| 1 | In vitro evaluation of free radical scavenging activity of Codariocalyx motorius root extract显示文摘Objective:To determine the phenolic content in Codariocalyx motorius root extract and to evaluate its antioxidant properties using various in vitro assay systems.Methods:The antioxidant activity was evaluated based on scavenging of 1,1—diphenyl—2—picrylhydrazyl,hydroxyl radicals,superoxide anions,nitric oxide,hydrogen peroxide,peroxvnilrile,reducing power and by inhibition oi lipid peroxidation which was estimated in terms of thiohurhituric acid reactive substances.Results:The root extract of the Codariocalyx motorius(C.motorius) exhibited potent total antioxidant activity that increased with increasing amount of extract concentration,which was compared with standard drug such as quercetin.butylaled hvdroxvloluene.tocopherol at different concentrations.The different concentrations of the extracts showed inhibition on lipid peroxidation.In addition,the extracts had effective reducing power,free radical scavenging, super oxide anion scavenging,nitric oxide scavenging,lipid peroxidation,and total phenolic content depending on concentration.High correlation between total phenolic contents and scavenging potential of different reactive oxygen species(r^2=0.83 1 -0.978) indicated the polyphenols as the main antioxidants.Conclusions:Codariocalyx motorius(C.motorius) root possess the highly active antioxidant substance which can be used for the treatment of oxidative stress-related diseases. | Uma Chidambaram Vanitha Pachamuthu Suganya Natarajan Bhakkiyalakshmi Elango Suriyanarayanan Kunga Mohan Ramkumar | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，3： | 2 |
| 2 | Stem cell markers:ABCG2 and MCM2 expression in retinoblastoma 显示文摘 | Mohan A Kandalam M Ramkumar H Subramantan K | 2006 | Br J Ophthalmol2006，90，7： | 1 |
| 3 | Stem cell markers: ABCG2 and MCM2 expression in retinoblastoma显示文摘 | Mohan A Kandalam M Ramkumar HL | 2006 | Br J Ophthalmol2006，90，： | 1 |
| 4 | Development and validation of functional marker targetingan InDel in the major rice blast disease resistance gene Pi54 (Pikh) 显示文摘 | Ramkumar G Srinivasarao K Mohan M K | 2011 | Mol Breeding2011，，27： | 1 |
| 5 | Stem cell markers: ABCG2 and MCM2 expression in retinoblastoma 显示文摘 | Mohan A Kandalam M Ramkumar HL | 2006 | Br J of Ophthalmol2006，90，7： | 1 |
| 6 | Stem cell markers: ABCG2 and MCM2 expression inretinoblastoma显示文摘 | Mohan A Kandalam M Ramkumar HL | 2006 | Br J Ophthal- mol2006，90，5： | 1 |
| 7 | Stem cell mar-kers:ABCG2 and MCM2 expression in retinoblastoma显示文摘 | Mohan A Kandalam M Ramkumar H L | 2006 | Br J Ophthalmol2006，90，7： | 1 |
| 8 | Nucleotide diversity of Pita , a major blast resistance gene and identification of its minimal promoter显示文摘 | G. Ramkumar M.S. Madhav S.J.S. Rama Devi P. Manimaran K.M. Mohan M.S. Prasad S.M. Balachandran C.N. Neeraja R.M. Sundaram B.C. Viraktamath | 2014 | Gene2014，，： | 1 |
| 9 | Stem cell markers: ABCG2 and MCM2 expression in retinoblastoma 显示文摘 | Mohan A Kandalam M Ramkumar HL | 2006 | Br J Ophthalmol2006，90，7： | 1 |
| 10 | Stem cell markers: ABCG2 and MCM2 expression in retinoblastoma 显示文摘 | Mohan A Kandalam M Ramkumar HL | 2006 | Br J Ophthalmol2006，90，7： | 1 |
| 11 | Stem cell markers:ABCG2 and MCM2 expression in retinoblastoma显示文摘 | Mohan A Kandalam M Ramkumar H L | 2006 | Br J Ophthalmol2006，90，7： | 1 |
| 12 | Inhibitory effect of Gymnema Montanum leaves on α-glucosidase activity and α-amylase activity and their relationship with polyphenolic content显示文摘 | Kunga Mohan Ramkumar Balsamy Thayumanavan Thayumanavan Palvannan Palanisamy Rajaguru | 2010 | Medicinal Chemistry Research2010，，8： | 1 |
| 13 | Stem cell markers:ABCG2 and MCM2 expression in retinoblastoma 显示文摘 | Mohan A Kandalam M Ramkumar HL | 2006 | Br J Ophthalmo12006，90，： | 1 |
| 14 | Elderly patients(≥80 years)with acute calculous cholangitis have similar outcomes as non-elderly patients(<80 years):Propensity score-matched analysis显示文摘BACKGROUND Acute cholangitis(AC)is a disease spectrum with varying extent of severity.Age≥75 years forms part of the criteria for moderate(Grade II)severity in both the Tokyo Guidelines(TG13 and TG18).Aging is associated with reduced physiological reserves,frailty,and sarcopenia.However,there is evidence that age itself is not the determinant of inferior outcomes in elective and emergency biliary diseases.There is a paucity of reports comparing clinical outcomes amongst elderly patients vs non-elderly patients with AC.AIM To investigate the effect of age(≥80 years)on AC's morbidity and mortality using propensity score matching(PSM).METHODS This is a single-center retrospective cohort study of all patients diagnosed with calculous AC(January 2016 to December 2016)and≥80 years old(January 2012 to December 2016)at a tertiary university-affiliated teaching hospital.Inclusion criteria were patients who were treated for suspected or confirmed AC secondary to biliary stones.Patients with AC on a background of hepatobiliary malignancy,indwelling permanent metallic biliary stents,or concomitant pancreatitis were excluded.Elderly patients were defined as≥80 years old in our study.A 1:1 PSM analysis was performed to reduce selection bias and address confounding factors.Study variables include comorbidities,vital parameters,laboratory and radiological investigations,and type of biliary decompression,including the time for endoscopic retrograde cholangiopancreatography(ERCP).Primary outcomes include in-hospital mortality,30-d and 90-d mortality.Length of hospital stay(LOS)was the secondary outcome.RESULTS Four hundred fifty-seven patients with AC were included in this study(318 elderly,139 non-elderly).PSM analysis resulted in a total of 224 patients(112 elderly,112 non-elderly).The adoption of ERCP between elderly and non-elderly was similar in both the unmatched(elderly 64.8%,non-elderly 61.9%,P=0.551)and matched cohorts(elderly 68.8%and non-elderly 58%,P=0.096).The overall in-hospital mortality,30-d mortality and 90-d mortality was 4.6%,7.4%and 8.5%respectively,with no statistically significant differences between the elderly and non-elderly in both the unmatched and matched cohorts.LOS was longer in the unmatched cohort[elderly 8 d,interquartile range(IQR)6-13,vs non-elderly 8 d,IQR 5-11,P=0.040],but was comparable in the matched cohort(elderly 7.5 d,IQR 5-11,vs non-elderly 8 d,IQR 5-11,P=0.982).Subgroup analysis of patients who underwent ERCP demonstrated the majority of the patients(n=159/292,54.5%)had delayed ERCP(>72 h from presentation).There was no significant difference in LOS,30-d mortality,90-d mortality,and in-hospital mortality in patients who had delayed ERCP in both the unmatched and matched cohort matched cohort:in-hospital mortality[n=1/42(2.4%)vs 1/26(3.8%),P=0.728],30-d mortality[n=2/42(4.8%)vs 2/26(7.7%),P=0.618],90-d mortality[n=2/42(4.8%)vs 2/26(7.7%),P=0.618],and LOS(median 8.5 d,IQR 6-11.3,vs 8.5 d,IQR 6-15.3,P=0.929).CONCLUSION Mortality is indifferent in the elderly(≥80 years old)and non-elderly patients(<80 years old)with AC. | Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Hepatology2021，13，4： | 1 |
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