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| 1 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 2 | Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study显示文摘 | Alessandro Vitale Rafael Ramirez Morales Giacomo Zanus Fabio Farinati Patrizia Burra Paolo Angeli Anna Chiara Frigo Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Catur | 2011 | Lancet Oncology2011，，7： | 2 |
| 3 | From val ue chain to value constellation:designing interactive strat egy显示文摘 | NORMANN RICHARD RAFAEL RAMIREZ | 1993 | Harvard Business Review1993，，78： | 1 |
| 4 | From value chain to value constellation:designing insteractive strategy显示文摘 | Normann Richard Ramirez Rafael | 1993 | Harvard Business Review1993，71，4： | 1 |
| 5 | From value chain to value constellation: Designing Interactive Strategic显示文摘 | Richard morman Rafael Ramirez | 1993 | Harvard Business Review1993，，4： | 1 |
| 6 | Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study显示文摘 | Alessandro Vitale Rafael Ramirez Morales Giacomo Zanus Fabio Farinati Patrizia Burra Paolo Angeli Anna Chiara Frigo Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Catur | 2011 | Lancet Oncology2011，，7： | 1 |
| 7 | From Value Chain to Value Constellation: Designing Interactive Strategy 显示文摘 | Normann Richard and Rafael Ramirez | 1993 | Harvard Business Review1993，71，78： | 1 |
| 8 | From Value Chain to Value Constelation:Designing Interactive Strategy显示文摘 | Richard Norman Rafael Ramirez | | 0，，7： | 1 |
| 9 | From Value Chain to Value Constellation : Designing Interactive Strategy 显示文摘 | Normann Richard Rafael Ramirez | 1993 | Harvard Business Review1993，71，78： | 1 |
| 10 | From Value Chain to Value Constellation: Designing Interactive Strategy显示文摘 | Richard Normann and Rafael Ramirez | 1993 | Harvard Business Review1993，，71： | 1 |
| 11 | From value chain to value constellation: Designing interactive strategy显示文摘 | Richard Norrnann and Rafael Ramirez | 1993 | Harvard Business Review1993，71，78： | 1 |
| 12 | From Value Chain to Value Constellation:Designing Interactive Strategy显示文摘 | Rechard Normann Rafael Ramirez | 1993 | Harvard Business Review1993，，7： | 1 |
| 13 | From Value Chain to Value Constellation: Designing Interactive Strategy 显示文摘 | Normann Richard and Rafael Ramirez | 1993 | Harvard Business Review1993，，78： | 1 |
| 14 | From Value Chain to Value Constellation :Designing Interactive Strategy显示文摘 | Richard Normann and Rafael Ramirez | 1993 | Harvard Business Review1993，71，78： | 1 |
| 15 | From Value Chain to Value Constellation: Designing Interactive Strategy 显示文摘 | Richard Normann and Rafael Ramirez | 1993 | Harvard Business Review1993，71，4： | 1 |
| 16 | High-Temperature Volatilization Mechanismof Stibnite in Nitrogen-Oxygen Atmospheres 显示文摘 | RAFAEL PADILLA GUSTAVO RAMIREZ MARIAC RUIZ | 2010 | Metallurgical and Materials Transactions B2010，416，： | 1 |
| 17 | 'From Value Chain to Value Constellation:Designing Interactive Strategy'显示文摘 | Normann Richard and Rafael Ramirez | 1993 | Harvard Business Review1993，71，78： | 1 |
| 18 | From value chain to value constellation:designing interactive strategy显示文摘 | Rafael Ramirez | 1993 | Harvard Business Review1993，71，4： | 1 |
| 19 | From Value Chain to Value Constellation: Desinging Interactive Strategy显示文摘 | Richard Normann and Rafael Ramirez | 1997 | Harvard Business Review1997，75，4： | 1 |
| 20 | From Value Chain to Value Constellation:Designing Interactive Strategy 显示文摘 | Richard Normann and Rafael Ramirez | 1993 | Harvard Business Review1993，71，78： | 1 |
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