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| 1 | Weaning stress and gastrointestinal barrier development:Implications for lifelong gut health in pigs显示文摘The gastrointestinal(GI) barrier serves a critical role in survival and overall health of animals and humans. Several layers of barrier defense mechanisms are provided by the epithelial, immune and enteric nervous systems. Together they act in concert to control normal gut functions(e.g., digestion,absorption, secretion, immunity, etc.) whereas at the same time provide a barrier from the hostile conditions in the luminal environment. Breakdown of these critical GI functions is a central pathophysiological mechanism in the most serious GI disorders in pigs. This review will focus on the development and functional properties of the GI barrier in pigs and how common early life production stressors, such as weaning, can alter immediate and long-term barrier function and disease susceptibility.Specific stress-related pathophysiological mechanisms responsible for driving GI barrier dysfunction induced by weaning and the implications to animal health and performance will be discussed. | Adam J.Moeser Calvin S.Pohl Mrigendra Rajput | 2017 | Animal Nutrition2017，，4： | 33 |
| 2 | Brazilin from Caesalpinia sappan heartwood and its pharmacological activities:A review显示文摘Caesalpinia sappan L.(CS) is a plant of Leguminosae family,commonly known as Brazil or Sappan wood.CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties.Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h.Chemical constituent's investigation of sappan wood resulled in the isolation of various structural types of phenolic components including one xanihone,one coumarin,three chalcones,two flavones three homoisoflavonoids and brazilin.Brazilin[(6a S-cis)-7,11b-dihydrobcnz[b]indeno[1.2-d]pyran-3.6a.9.10(6H)- tetroll.a major and active compound found in CS heartwood.Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant,antibacterial,anti-inflammatory,anti-photoaging.hypoglycemic,vasorelaxant,hepatoproteetive and anti-acne activity.CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats.Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food,beverage,cosmetics and pharmaceutical industries to screen its clinical use in modern medicine.The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities.More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries. | Nilesh P Nirmal Mithun S Rajput Rangabhatla G.S.V.Prasad Mehraj Ahmad | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，6： | 14 |
| 3 | Adjuvant effects of saponins on animal immune responses显示文摘Vaccines require optimal adjuvants including immunopotentiator and delivery systems to offer long term protection from infectious diseases in animals and man. Initially it was believed that adjuvants are responsible for promoting strong and sustainable antibody responses. Now it has been shown that adjuvants influence the isotype and avidity of antibody and also affect the properties of cell-mediated immunity. Mostly oil emulsions, lipopolysaccharides, polymers, saponins, liposomes, cytokines, ISCOMs (immunostimulating complexes), Freund’s complete adjuvant, Freund’s incomplete adjuvant, alums, bacterial toxins etc., are common adjuvants under investigation. Saponin based adjuvants have the ability to stimulate the cell mediated immune system as well as to enhance antibody production and have the advantage that only a low dose is needed for adjuvant activity. In the present study the importance of adjuvants, their role and the effect of saponin in immune system is reviewed. | RAJPUT Zahid Iqbal ARIJO Abdullah G. | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，3： | 7 |
| 4 | Inactivation of infectious bursal disease virus by binary ethylenimine and formalin显示文摘In this experiment conducted to study the inactivation dynamics of infectious bursal disease virus (IBDV) by binary ethylenimine (BEI) in comparison with formalin, IBDV was isolated from the bursa of infected chickens and its confirmation was done by agar gel precipitation test. Viral suspensions were subjected to inactivation with BEI and formalin for pre-set time in-tervals. BEI was employed at concentrations of 0.001 and 0.002 mol/L while formalin was used at 0.1% and 0.2%. Sampling was done at 6, 12, 24, 36 and 48 h of incubation and samples were tested for their inactivation status in 9-day-old embryonated eggs and 3-week-old broiler chickens. IBDV was completely inactivated by 0.001 and 0.002 mol/L BEI after 36 h of incubation at 37 °C, whereas formalin at 0.1% and 0.2% concentrations inactivated IBDV in 24 h. | HABIB M. HUSSAIN I. FANG W.H. RAJPUT Z.I. YANG Z.Z. IRSHAD H. | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，4： | 6 |
| 5 | Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats显示文摘Objective:To evaluate the hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatic damage in rats.Methods:The plant material was shade dried, powdered and extracted with ethanol.Liv 52 and silymarin were used as standard drugs and 2%gum acacia as a control(vehicle).Alteration in the levels of biochemical markers of hepatic damage like AST,ALT,ALP and lipid peroxides were tested,and phytochemical tests were also performed.Results:Paracetamol(2 g/kg) increased the serum levels of alanine aminotransfer (ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP) and the lipid peroxides. Treatment of Liv 52,silymarin and ethanolic extract of Terminalia paniculata(200 mg/kg) altered levels of biochemical marker and showed significant hepatoprotective activity.Ethanolic extract revealed the presence of phenolic compound and flavanoids.Our findings suggested that ethanolic bark extract of Terminalia paniculata possessed hepatoprotective activity in a dose dependent manner.Conclusions:Terminalia paniculata possesses hepatoprotective activity.It could be an effective and promising preventive agent against PCT induced hepatotoxicity. | Eesha BR Mohanbabu Amberkar V Meena Kumari K Sarath babu Vijay M Lalit M Rajput R | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 5 |
| 6 | Improvement of the efficacy of influenza vaccination (H5N1) in chicken by using extract of Cochinchina momordica seed (ECMS)显示文摘Seeds of a Chinese traditional medicine plant, Cochinchina momordica were used in the present study for the improvement of influenza vaccine (H5N1) in chicken. Crude extraction from Cochinchina momordica seed (ECMS) was obtained by ethanol extraction method. In experiment No. 1, two weeks old chickens were immunized with influenza vaccine (H5N1) alone or combined with ECMS (5, 10, 20, 40 and 80 μg/dose). Serum IgG antibody levels (by ELISA) as well as effects on daily weight gain were measured on 0, 7, 14 and 28th day after immunization. Results revealed that all ECMS groups numerically increased the antibody levels while 10 and 20 μg/dose groups significantly (P<0.05) enhanced total IgG antibody on day 28, when compared with control. Average daily weight gain was also significantly higher in 20 μg/dose ECMS group. Adjuvant effect was also confirmed in experiment No. 2 when chickens were immunized with 20 μg/dose ECMS and antibody titer was measured through hemagglutination inhibition (HI). It is concluded that ECMS has potential to improve the immune responses and deserve further study as an adjuvant. | RAJPUT Zahid Iqbal XIAO Chen-wen HU Song-hua ARIJO Abdullah G. SOOMRO Noor Mohammad | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，5： | 4 |
| 7 | Inhibition of ADP-induced platelet aggregation and involvement of non-cellular blood chemical mediators are responsible for the antithrombotic potential of the fruits of Lagenaria siceraria显示文摘AIM: The fruits of Lagenaria siceraria(Molina) Standl.(Cucurbitaceae), a commonly used vegetable, are reported to possess various medicinal properties. In previous studies, the fibrinolytic potential of an ethanolic extract of fruits of Lagenaria siceraria was investigated in comparison with kaempferol isolated from it. The aim of the present study was to explore its mechanistic antithrombotic potential and antiplatelet activity using a wide dose range in different in vitro and in vivo models, and to quantify the total phenolic, flavonoid, and kaempferol contents using a colorimetric method. METHOD: The antithrombotic potential was investigated using tail bleeding time in mice, a plasma recalcification assay, and pulmonary thromboembolism in mice. The antiplatelet activity was studied using an in vitro model to investigate IC50 value. RESULTS: A significant amount of total phenols, flavonoids, and kaempferol was quantified in L. siceraria ethanolic extract. An ethanolic extract of the fruits of L. siceraria showed a significant increase in tail bleeding time and plasma recalcification time, significant protection against ADP induced pulmonary thromboembolism in mice, and also inhibited the platelet aggregation induced by ADP in vitro. The study suggested that the fruits of L. siceraria exhibit significant antithrombotic potential due to inhibition of ADP-mediated platelet aggregation and the involvement of various non-cellular chemical mediators of blood. CONCLUSION: This finding may be helpful in treating the serious consequences of the thrombus formed in blood vessels which include atherothrombotic diseases, such as myocardial or cerebral infarction. So, further investigation should be done for revealing exact mechanism of action behind these types of activities. | Mithun Singh Rajput Neelam Balekar Dinesh Kumar Jain | 2014 | Chinese Journal of Natural Medicines2014，12，8： | 2 |
| 8 | High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes显示文摘Context:The role of glycated haemoglobin(HbA1c)in the prediction of ischaemic stroke in individuals without diabetes is underestimated.Aims:We performed a study to analyse the role of HbA1c in the risk prediction of ischaemic stroke in Pakistani population without diabetes.We further studied the difference between HbA1c values of individuals with diabetes and without diabetes with stroke.Settings and design:Single centre,case–control.Materials and methods:In phase I,a total of 233 patients without diabetes with ischaemic stroke and 245 as controls were enrolled.Association of HbA1c levels,lipid profiles and blood pressure recordings with ischaemic stroke was analysed.In phase II,comparison was done between diabetics and nondiabetics with stroke.Statistical analysis:Comparison of the mean variables was performed with Student’s t-tests.Logistic regression analysis with ischaemic stroke as the dependent variable was performed for phase I.Results:In phase I,the ischaemic stroke group had significantly higher HbA1c levels(5.9±2.9%vs 5.5±1.6%)compared with controls(p<0.05).Triglyceride cholesterol,high-density lipoprotein cholesterol,systolic blood pressure,diastolic blood pressure and HbA1c were the significant determinants of stroke(p<0.05).In phase II,mean HbA1c values were significantly higher in the diabetes group(7.6±2.1 vs 6.1±2.3)(p<0.05)but other parameters were not statistically significantly different(p>0.05).Conclusions:Higher HbA1c indicated a significantly increased risk for ischaemic stroke.An HbA1c value above 5.6%(prediabetic range)predicted future risk of stroke and efforts to maintain glucose level within the normal range(≤5.6%)in individuals with high cardiovascular risk are important. | Ali Zohair Nomani Sumaira Nabi Shahzad Ahmed Mansoor Iqbal Haris Majid Rajput Suhail Rao | 2016 | Stroke & Vascular Neurology2016，1，3： | 2 |
| 9 | Amantadine: an antiparkinsonian agent inhibits bovine brain 60<ce:hsp sp='0.25'/>kDa calmodulin-dependent cyclic nucleotide phosphodiesterase isozyme显示文摘 | Rakesh Kakkar Rajala V.S. Raju Ali H. Rajput Rajendra K. Sharma | 1997 | Brain Research1997，，2： | 2 |
| 10 | Entropy-based link prediction in weighted networks显示文摘Information entropy has been proved to be an effective tool to quantify the structural importance of complex networks.In a previous work [Xu et al. Physica A, 456 294(2016)], we measure the contribution of a path in link prediction with information entropy. In this paper, we further quantify the contribution of a path with both path entropy and path weight,and propose a weighted prediction index based on the contributions of paths, namely weighted path entropy(WPE), to improve the prediction accuracy in weighted networks. Empirical experiments on six weighted real-world networks show that WPE achieves higher prediction accuracy than three other typical weighted indices. | 许忠奇 濮存来 Rajput Ramiz Sharafat 李伦波 杨健 | 2017 | Chinese Physics B2017，26，1： | 2 |
| 11 | Comparative study of Anaplasma parasites in tick carrying buffaloes and cattle显示文摘A comparative study on the prevalence of Anaplasma parasite was conducted on ticks carrying buffaloes and cattle. Five hundred blood samples of both animals (250 of each) were collected during February, March and April. Thin blood smears on glass slides were made, fixed in 100% methyl alcohol and examined. Microscopic examination revealed that 205 (41%) animals had Anaplasma parasites, out of which 89, 44 and 72 animals had Anaplasma marginale, Anaplasma centrale and mixed infection respectively. Infected buffaloes and cattle were 75 and 130 respectively. The infection in female was 53 and 92 in buffaloes and cattle respectively. Twenty-two and 92 blood samples of male were found positive in buffaloes and cattle respectively. Com- parative study revealed that the cattle were 26.82% more susceptible than buffaloes. The parasite prevailing percentage in female of both animals was slightly higher than that of the male. This investigation was aimed at studying the comparative prevalence of Anaplasma parasite in tick carrying buffaloes and cattle. | RAJPUT Z.I. 胡松华 ARIJO A.G. HABIB M. KHALID M. | 2005 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2005，6，11： | 2 |
| 12 | Study of cellulolytic soil fungi and two nova species and new medium显示文摘This study is aimed at identifying and determining the percentage of occurrence frequency of cellulose decomposing soil fungi. The soil samples were inoculated into culture plates prepared in Sabouraud medium under sterilized conditions and incubated at 30 °C for 4 to 7 d. The identified fungal species were incubated in self-designed cellulose medium for testing their cellulolytic ability. Forty-two species, including 2 nova species, representing sixteen genera showed growth and sporulation in the cellulose medium. Most of the isolated species were from genus Aspergillus and Penicillium. Aspergillus niger and Mucor hie-malis showed highest occurrence frequency (45% and 36% respectively), as these species were collected from about 80% of soil samples. Being agar free and cheaper, the new fungal medium designed showed results equivalent to Sabouraud medium. | KHALID Mahmood YANG Wei-jun KISHWAR Nazir RAJPUT Zahid Iqbal ARIJO Abdullah G. | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，6： | 2 |
| 13 | Mutation of the type H transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas 显示文摘 | GRADY WM RAJPUT A MYEROFF L | 1998 | Cancer Res1998，58，14： | 1 |
| 14 | 显示文摘 | Rajput S Nandwani SK Phadke AY | 2000 | Indian J Gastroenterol2000，19，3： | 1 |
| 15 | Parkinson's disease,stroke,and related epidemiology显示文摘 | Nataraj A Rajput AH | 2005 | Mov Disord2005，20，11： | 1 |
| 16 | Mutation of the type Ⅱ transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas显示文摘 | GradyWM Rajput A Myeroff L | | 0，，： | 1 |
| 17 | Automatic dete(:tion of mi- croaneurysms from fundus images using morphological opera- tions显示文摘 | GG Rajput PN Patil R Chavan | 2013 | Signals & Systems and Networking2013，256，35： | 1 |
| 18 | Simulation of soil wetting pattern with subsurface drip irrigation from line source显示文摘 | Singh D K Rajput T B S Singh D K | 2006 | Agricultural Water Management2006，83，1： | 1 |
| 19 | Perforraance evaluation of AquaCmp model for maize crop in a semi-arid environment显示文摘 | Abedinpour M Sarangi A Rajput T B S | 2012 | Agricultural Water Management2012，，110： | 1 |
| 20 | Progressive supranuclear palsy:clinical features,pathophysiology and management显示文摘 | Rajput A Rajput AH | 2001 | Drugs Aging2001，18，12： | 1 |
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