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| 1 | Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug显示文摘The purpose of the present study was to investigate the interaction of Cinnarizine(CIN)with Hydroxypropyl-β-Cyclodextrin(HPβCD)in the presence of Hydroxy Acids(HA).Various binary and ternary systems of CIN with HPβCD and HA were prepared by kneading and coevaporation methods.For the ternary systems,HA were tried in three different concentrations.The interaction in solution phase was studied in detail by the phase solubility method,and the solid phase interactions were characterized by Fourier Transform Infrared(FTIR)spectroscopy,Differential Scanning Calorimetry(DSC),X-Ray Diffractometry(XRD),Scanning Electron Microscopy(SEM)and Proton Nuclear Magnetic Resonance(^1H-NMR).Phase solubility revealed the positive effect of HA on the complexation of CIN with HPβCD.Solid phase characterization confirmed the formation of inclusion complex in the ternary systems.Solubility and dissolution studies illustrated that out of three different concentrations tried,HA were most effective at the 1 M concentration level.Ternary systems were very effective in improving the solubility as well as dissolution profile of CIN than the CIN–HPβCD binary systems.FTIR,^1H-NMR and Molecular docking studies gave some insight at molecular level that actually which part of CIN was interacting with the HPβCD.Molecular docking and free energy calculation even enlighten the role of tartaric acid in increasing solubility of CIN in the ternary system. | Mayank Patel Rajashree Hirlekar | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 2 |
| 2 | Animal models in the study of Alzheimer's disease and Parkinson's disease:A historical perspective显示文摘Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally.Both are proteinopathic conditions and while occasionally inherited,are largely sporadic in nature.Although the advances in our understanding of the two have been significant,they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful.Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research.This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease,and highlights the shifting paradigms in studying two humanspecific conditions in non-human organisms. | Rajashree Banerjee Arushi Rai Shreyas M.Iyer Sonia Narwal Meghana Tare | 2022 | Animal Models and Experimental Medicine2022，5，1： | 2 |
| 3 | A newfangled study using risk silhouette and uncertainty approximation for quantification of acyclovir in diverse formulation显示文摘Risk assessment and uncertainty approximation are two major and important parameters that need to be adopted for the development of pharmaceutical process to ensure reliable results.Additionally,there is a need to switch from the traditional method validation checklist to provide a high level of assurance of method reliability to measure quality attribute of a drug product.In the present work,evaluation of risk profile,combined standard uncertainty and expanded uncertainty in the analysis of acyclovir were studied.Uncertainty was calculated using cause-effect approach,and to make it more accurately applicable a method was validated in our laboratory as per the ICH guidelines.While assessing the results of validation,the calibration model was justified by the lack of fit and Levene's test.Risk profile represents the future applications of this method.In uncertainty the major contribution is due to sample concentration and mass.This work demonstrates the application of theoretical concepts of calibration model tests,relative bias,risk profile and uncertainty in routine methods used for analysis in pharmaceutical field. | Karan Mittal Riddhish Patadia Chintan Vora Rajashree C.Mashru | 2015 | Journal of Pharmaceutical Analysis2015，5，1： | 2 |
| 4 | Preparation and characterization of inclusion complexes of carvedilol with methyl-β-cyclodextrin显示文摘 | Rajashree Hirlekar Vilasrao Kadam | 2009 | Journal of Inclusion Phenomena and Macrocyclic Chemistry (-)2009，，3： | 1 |
| 5 | Treatment of cyanide containing wastewater using cavitation based approach显示文摘 | Rajashree H J Parag R G | 2014 | Ultrason Sonochem2014，21，4： | 1 |
| 6 | Nonlinear Finite-element Modeling of Batter Piles under Lateral Load显示文摘 | I RAJASHREE S S SITHARAM T G | 2001 | Journal of Geotechni- cal and Geoenvironmental Engineering ASCE2001，127，7： | 1 |
| 7 | A bayesian approach to dynamic inventory model under an unknown demand distribution 显示文摘 | K Rajashree Kamath T P M Pakkala | 2002 | Computers & Operations Research2002，29，2： | 1 |
| 8 | Degradation model for one-way cyclic lateral load on piles in soft clay显示文摘 | RAJASHREE S S SUNDARAVADIVELU R | 1996 | Computers and Geoteehnics1996，19，4： | 1 |
| 9 | An in-situ gelling system for parenteral delivery 显示文摘 | Rajashree J Himmelstein KJ | 1996 | J Control Release1996，41，3： | 1 |
| 10 | A Bayesian approach to a dynamic inventory model under an unknown demand distribution显示文摘 | Kamath K Rajashree T P M Pakkala | 2002 | Computers&Operations Research2002，29，4： | 1 |
| 11 | Influence of bio-fertilizers on the growth characters,yield attributes,yield and quality of tomato显示文摘 | PREMSEKHAR M RAJASHREE V | | 0，，01： | 1 |
| 12 | Nonlinear Finite-Element Modeling of Batter Piles under Lateral Loads, Journal of Geotechnical and Geoenvironmental显示文摘 | Rajashree S S Sitharam T G | 2001 | Engineering2001，127，7： | 1 |
| 13 | Nonlinear finite-element modeling of batter piles under lateral load 显示文摘 | RAJASHREE S S SITHARAM T G | 2001 | Journal of Geotechnical and Geoenviromental Engineering2001，127，7： | 1 |
| 14 | TLR2 and TLR4 expres- sion on the immune cells of tuberculous pleural fluid显示文摘 | Prabha C Rajashree P Sulochana DD | 2008 | Immunol Lett2008，117，1： | 1 |
| 15 | A Bayesian ap- proach to a dynamic inventory model under an unknown demand distribution显示文摘 | RAJASHREE K K PAKKALA T P M | 2002 | Computers & Operations Research2002，，29： | 1 |
| 16 | An in-situ gelling system for parenteral delivery 显示文摘 | Haglund BO Rajashree J Himmelstein KJ | 1996 | J Control Release1996，41，3： | 1 |
| 17 | Indistinguishable cellular changes in gastric mucosa between Helicobacter pylori infected asymptomatic tribal and duodenal ulcer patients显示文摘AIM:To investigate the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori (H pylori) infected tribal populations and duodenal ulcer patients among ethnic Bengalis and correlation of the genotypes of H pylori with different histological parameters.were enrolled into this study between 2002 and 2004. Among them,72 had clinical features of duodenal ulcer (DU) from ethnic Bengali population and 40 were asymptomatic ethnic tribals. Endoscopic gastric biopsy samples were processed for histology,genotyping and rapid urease test. Histologically,haematoxylin and eosin staining was applied to assess the pathomorphological changes and a modified Giemsa staining was used for better detection of H pylori. For intestinal metaplasia,special stainings,i.e. Alcian blue periodic acid-Schiff and high iron diamine-Alcian blue staining,were performed. PCR was performed on bacterial DNA to characterize the presence or absence of virulence-associated genes,like cagA,and distribution of different alleles of vacA and iceA. RESULTS:Intraglandular neutrophil infiltration,a hallmark of activity of gastritis,was present in 34 (94%) of tribals (TRs) and 42 (84%) of DU individuals infected with H pylori. Lymphoid follicles and aggregates,which are important landmarks in H pylori infection,were positive amongst 15 (41%) of TRs and 20 (40%) of DU subjects. Atrophic changes were observed in 60% and 27.7%,respectively,among DU cases and tribals (P > 0.003). Metaplastic changes were detected in low numbers in both groups. Moderate to severe density distribution of H pylori in the gastric mucosa was 63% among TRs,whereas it was 62% in DU subjects. There were no significant differences in the distribution of virulence-associated genes like cagA,vacA and iceA of H pylori strains carried by these two populations. CONCLUSION:Our study showed almost similar distribution of inflammatory cells among asymptomatic tribals and DU Bengali patients. Interestingly,the tribal population are free from any clinical symptoms despite evidence of active histologic gastritis and infection with H pylori strains carrying similar virulence markers as of strains isolated from patients with DU. There was an increased cellular response,especially in terms of neutrophil infiltration,but much lower risk of developing atrophy and metaplastic changes among the tribal population. | Dhira Rani Saha Simanti Datta Santanu Chattopadhyay Rajashree Patra Ronita De Krishnan Rajendran Abhijit Chowdhury Thandavaryan Ramamurthy Asish Kumar Mukhopadhyay | 2009 | World Journal of Gastroenterology2009，15，9： | 1 |
| 18 | A Bayesian Approach to a Dynamic Inventory Model Under an Unknown Demand Distribution 显示文摘 | Rajashree K K Pakkala T P M | 2002 | Computers & Operations Research2002，，29： | 1 |
| 19 | Nonlinear finite-element modeling of batter piles under lateral load显示文摘 | SITHARAM T G RAJASHREE S S | 2001 | Journal of Geotechnical and Geoenvironmental Engineering2001，127，7： | 1 |
| 20 | A Bayesian approach to a dynamic inventory model under an unknown demand distribution显示文摘 | Kamath K Rajashree T P M Pakkala | 2002 | Computers & Operations Research2002，29，： | 1 |
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