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| 1 | 响应面法优化沙拉沙星/β-环糊精包合物制备工艺与稳定性评价显示文摘为制备沙拉沙星/β-环糊精包合物微囊,解决沙拉沙星原药溶解度低,理化性质不稳定的问题。通过响应面法优化沙拉沙星/β-环糊精包合物的制备工艺,采用液相色谱法对沙拉沙星/β-环糊精包合物进行载药量及溶解度测定,以干燥失重试验和影响因素试验对沙拉沙星/β-环糊精包合物的含水量与稳定性进行评价。结果显示,优化后的包合工艺参数为沙拉沙星与β-环糊精摩尔比1∶2,搅拌温度50℃,搅拌时间4 h,喷雾干燥工艺为温度160℃,泵速6.3 r·min^(-1)。液相色谱方法学结果表明:沙拉沙星在质量浓度9.94~99.40μg·mL^(-1)范围内,线性关系优良,回归方程为Y=34.66X-15.867,相关系数为0.9999。影响因素试验与干燥失重试验表明,制备的沙拉沙星/β-环糊精包合物物理化学性质稳定,包合物含水量小于2%,流动性良好。结果表明,沙拉沙星/β-环糊精包合物的成功制备明显改善了药物的理化性质,对沙拉沙星的应用与推广具有积极作用。 | 姜兴粲 李冰 杨敏 张继瑜 | 2021 | 浙江农业学报2021，33，3： | 2 |
| 2 | Water-Based Environmentally Friendly Pesticide Formulations Based on Cyclodextrin/Pesticide Loading System显示文摘Difenoconazole(DIF)is a representative variety of broad-spectrum triazole fungicides and liposoluble pesticides.However,the water solubility of DIF is so poor that its application is limited in plant protection.In addition,the conventional formulations of DIF always contain abundant organic solvents,which may cause pollution of the environment.In this study,two DIF/cyclodextrins(CDs)inclusion complexes(ICs)were successfully prepared,which were DIF/β-CD IC and DIF/hydroxypropyl-β-CD IC(DIF/HP-β-CD IC).The effect of cyclodextrins on the water solubility and the antifungal effect of liposoluble DIF pesticide were investigated.According to the phase solubility test,the molar ratio and apparent stability constant of ICs were obtained.Fourier transform infrared spectroscopy,thermal gravity analysis,X-ray diffraction and scanning electron microscopy were used systematically to characterize the formation and characteristics of ICs.The results noted that DIF successfully entered the cavities of two CDs.In addition,the antifungal effect test proved the better performance of DIF/HP-β-CD IC,which exceeded that of DIF emulsifiable concentrate.Therefore,our study provides informative direction for the intelligent use of liposoluble pesticides with cyclodextrins to develop water-based environmentally friendly formulations. | Xinyu Guo Zhe Sun Rui Zhao Hongyi Shang Jiangyu Liu Yong Xu Laihua Liu Xuemin Wu | 2023 | Journal of Renewable Materials2023，11，2： | 0 |
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