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| 1 | Role of autophagy in liver physiology and pathophysiology显示文摘Autophagy is a highly conserved intracellular degradation pathway by which bulk cytoplasm and superfluous or damaged organelles are enveloped by double membrane structures termed autophagosomes. The autophago-somes then fuse with lysosomes for degradation of their contents, and the resulting amino acids can then recycle back to the cytosol. Autophagy is normally activated in response to nutrient deprivation and other stressors and occurs in all eukaryotes. In addition to maintaining energy and nutrient balance in the liver, it is now clear that autophagy plays a role in liver protein aggregates related diseases, hepatocyte cell death, steatohepatitis, hepatitis virus infection and hepatocellular carcinoma. In this review, I discuss the recent findings of autophagy with a focus on its role in liver pathophysiology. | Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States | 2010 | World Journal of Biological Chemistry2010，1，1： | 9 |
| 2 | Cell surface activation of progelatinase A (proMMP-2) and cell migration显示文摘Gelatinase A (MMP-2) is considered to play a critical role in cell migration and invasion. The proteinase is secreted from the cell as an inactive zymogen. In vivo it is postulated that activation of progelationase A (proMMP-2) takes place on the cell surface mediated by membrane-type matrix metalloproteinases (MT-MMPs). Recent studies have demonstrated that proMMP-2 is recruited to the cell surface by interacting with tissue inhibitor of metalloproteinases-2 (TIMP-2) bound to MT1MMP by forming a ternary complex. bee MT1-MMP closely located to the ternary complex then activates proMMP-2 on the cell surface. MT1-MMP is found in cultured invasive cancer cells at the invadopodia. The MTMMP/TIMP-2/ MMP- 2 system t bus provides localized expression of proteolysis of the extracellular matrix required for cell migration. | NAGASE HIDEAKI(Department of Biochemistry and Molecular Biology,University of Kansas Medical Center, 3901 Rainbow Blvd,Kansas City, KS 66160. E-mail: hnagase@kumc.edu) | 1998 | Cell Research1998，8，3： | 6 |
| 3 | Metallothioneins in aquatic invertebrates: Their role in metal detoxification and their use as biomarkers显示文摘 | J.-C. Amiard C. Amiard-Triquet S. Barka J. Pellerin P.S. Rainbow | 2005 | Aquatic Toxicology2005，，2： | 2 |
| 4 | Studies on the uptake of cadmium by the crab Carcinus maenas in the laboratory. I. Accumulation from seawater and a food source显示文摘 | J. R. Jennings P. S. Rainbow | 1979 | Marine Biology1979，，2： | 2 |
| 5 | A randomized controlled trial of topical tea tree preparation for MRSA colonized wounds显示文摘Background:The prevalence of MRSA(Methicillin-resistant Staphylococcus aureus)colonized wounds in home care residents is expected to grow continuously as a result of the substantial proportion of older people requiring institutionalized care due to chronic disease and declining functional status,which contribute to more frequent skin breakdown and wound formation.Tea tree oil has been claimed to have anti-bacterial,analgesic and anti-inflammatory effects that have been suggested in many in-vitro studies to have good efficacy against MRSA.The aims of this study were to evaluate the effectiveness of 10%topical tea tree preparation to eradicateMRSA and to ascertain its influence on wound healing forMRSA-colonized wounds.Methods:It was a randomized controlled trial,single-blind study.Those with stage II or above MRSA-colonized wounds and who had given their informed consent formed the sample.The determined sample sizewasbasedonthe effect size of our previouspilot study,whichwas 0.46.Five outcome measurements were taken for the MRSA bacterial count and wound healing condition at baseline and at 1-week intervals during the 4-week dressing intervention period.Results:Thirty-two participants were recruited from two non-government nursing homes,16 in the control group and 16 in the tea tree oil group.The control group residents received routine saline gauze dressing,while the tea tree oil group residents received the 10%topical tea tree preparation dressing.In the tea tree oil group,all chronic wounds that had previously been delayed in healing were healed within 28 days without adverse reaction.MRSA was also completely eradicated in 14(87.5%)out of 16 wounds in the group receiving the 10%topical tea tree preparation. | Rainbow L.P.Lee Polly H.M.Leung Thomas K.S.Wong | 2014 | International Journal of Nursing Sciences2014，1，1： | 2 |
| 6 | The role of Nkx3.2 in chondrogenesis显示文摘抄写因素, Nkx3.2,是发展基因的 NK 家庭的一个成员并且在许多哺乳动物的模型有机体在 embryogenesis 期间被表示,包括鸡肉和老鼠。它首先作为风笛(bap ) 基因在果蝇被识别,在在 midgut 肌的形成期间必要被表明了的地方。然而,哺乳动物的相当或相同的事物 Nkx3.2 被显示了起一个重要作用在轴并且手足 skeletogenesis;特别地,人的骨胳的疾病, spondylo-megaepiphyseal-metaphyseal 发育异常(SMMD ) ,与 Nkx3.2 基因的变化被联系。在这评论,我们在肌与骨的开发期间加亮 Nkx3.2 的角色,与在决定 chondrogenic 房间命运的因素角色和它在 endochondral 骨化和 chondrocyte 幸存的随后的角色上的一个重音。 | Roshni S. RAINBOW Heenam KWON Li ZENG | 2014 | Frontiers in Biology2014，9，5： | 2 |
| 7 | Trace metal concentrations in aquatic invertebrates: why and so what 显示文摘 | RAINBOW P S | 2002 | Environmental Pollution2002，120，： | 1 |
| 8 | Metallothionein turnover, cytosolic distribution and the uptake of Cd by the green mussel Perna viridis显示文摘 | T.Y.-T. Ng P.S. Rainbow C. Amiard-Triquet J.C. Amiard W.-X. Wang | 2007 | Aquatic Toxicology2007，，2： | 1 |
| 9 | Metal toxicity, uptake and bioaccumlation in aquatic invertebtates-modelling zinc in crustaceans显示文摘 | Rainbow P S Luoma S N | 2001 | Aquatic Toxi- cology2001，105，3： | 1 |
| 10 | Comparative metal analyses in amphipod crustaceans显示文摘 | Rainbow P S Moore P G | 1986 | Hydrobiologia1986，141，： | 1 |
| 11 | Trace metal concentrations in aquatic invertebrates:why and so what显示文摘 | RAINBOW P S | | 0，，03： | 1 |
| 12 | In vivo kinematics of the scaphoid, lunate, capitate, and third metacarpal in extreme wrist flexion and extension显示文摘 | Rainbow MJ Kamal RN Leventhal E | 2013 | J Hand Surg Am2013，38，2： | 1 |
| 13 | Significance of metallothioneins in metal accumulation kinetics in marine animals 显示文摘 | Wang W X Rainbow P S | 2010 | Comparative Bio- chemistry and Physiology Part C: Toxicology & Pharmacology2010，152，1： | 1 |
| 14 | Biomonitoring of heavy metal availability in the marine environment显示文摘 | Rainbow P S | 1995 | Mar Pollut Bull1995，31，412： | 1 |
| 15 | Tolerance and accumulation of the trace metals zinc,copper and cadmium in three populations of the polychaete Nereis diversicolor显示文摘 | ZHOU Q X RAINBOW P S SMITH B D | 2003 | Journal of the Marine Biological Association of the UK2003，83，： | 1 |
| 16 | Comparative study of the tolerance and accumulation of the trace metals zinc, copper and cadmium in three populations of the polychaete Nereis diversicolor显示文摘 | Zhou Q X Rainbow P S Smith B D | 2003 | Journal of the Marine Biological Association of the United Kingdom2003，83，1： | 1 |
| 17 | Effects of high plant populations on the growth and yield of winter oilseed rape(Brassica napus)显示文摘 | LEACH J E STEVENSON H J RAINBOW A J | 1999 | Journal of Agricultural Science1999，132，2： | 1 |
| 18 | Biomonitoring of heavy metal availability in the marine environment 显示文摘 | | 1995 | Marine Pollution Bulletin1995，31，： | 1 |
| 19 | Cadmium,Zinc and the Uptake of Calcium by Two Crabs, Carcinus maenas and Eriocheir sinensis 显示文摘 | RAINBOW P S BLACK W H | 2005 | Aquatic Toxicology2005，72，12： | 1 |
| 20 | The loss,uptake and tissue distribution of copper and zinc during the moult cycle in an ecological series of talitrid amphipods(Crustacea:Amphipoda)显示文摘 | eeks J M Rainbow P S Moore P G | 1992 | Hydrobiologia1992，245，： | 1 |
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