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| 1 | Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor spread in rectal cancer显示文摘AIM:To evaluate the agreement between transrectal ultrasound(TRUS) and magnetic resonance imaging(MRI) in classification of ≥ T3 rectal tumors.METHODS:From January 2010 to January 2012,86 consecutive patients with ≥ T3 tumors were included in this study.The mean age of the patients was 66.4 years(range:26-91 years).The tumors were all ≥ T3 on TRUS.The sub-classification was defined by the penetration of the rectal wall:a:0 to 1 mm;b:1-5 mm;c:6-15;d:> 15 mm.Early tumors as ab(≤ 5 mm) and advanced tumors as cd(> 5 mm).All patients underwent TRUS using a 6.5 MHz transrectal transducer.The MRI was performed with a 1.5 T Philips unit.The TRUS findings were blinded to the radiologist performing the interpretation of the MRI images and measuring the depth of extramural tumor spread.RESULTS:TRUS found 51 patients to have an early ≥ T3 tumors and 35 to have an advanced tumor,whereas MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors.No patients with tumors classified as advanced by TRUS were found to be early on MRI.The kappa value in classifying early versus advanced T3 rectal tumors was 0.93(95% CI:0.85-1.00).We found a kappa value of 0.74(95% CI:0.63-0.86) for the total sub-classification between the two methods.The mean maximal tumor outgrowth measured by TRUS,5.5 mm ± 5.63 mm and on MRI,6.3 mm ± 6.18 mm,P = 0.004.In 19 of the 86 patients the following CT scan or surgery revealed distant metastases;of the 51 patients in the ultrasound ab group three(5.9%) had metastases,whereas 16(45.7%) of 35 in the cd group harbored distant metastases,P = 0.00002.The odds ratio of having distant metastases in the ultrasound cd group compared to the ab group was 13.5(95% CI:3.5-51.6),P = 0.00002.The mean maximal ultrasound measured outgrowth was 4.3 mm(95% CI:3.2-5.5 mm) in patients without distant metastases,while the mean maximal outgrowth was 9.5 mm(95% CI:6.2-12.8 mm) in the patients with metastases,P = 0.00004.Using the MRI classification three(6.3%) of 48 in the MRI ab group had distant metastases,while 16(42.1%) of the 38 in the MRI cd group,P = 0.00004.The MRI odds ratio was 10.9(95% CI:2.9-41.4),P = 0.00008.The mean maximal MRI measured outgrowth was 4.9 mm(95% CI:3.7-6.1 mm) in patients without distant metastases,while the mean maximal outgrowth was 11.5 mm(95% CI:7.8-15.2 mm) in the patients with metastases,P = 0.000006.CONCLUSION:There is good agreement between TRUS and MRI in the pretreatment sub-classification of ≥ T3 tumors.Distant metastases are more frequent in the advanced group. | Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John Plφen Anders Jakobsen | 2012 | World Journal of Gastroenterology2012，18，36： | 14 |
| 2 | Diagnostic Accuracy of Capsule Endoscopy for Small Bowel Crohn’s Disease Is Superior to That of MR Enterography or CT Enterography显示文摘 | Michael Dam Jensen Torben Nathan S?ren Rafael Rafaelsen Jens Kjeldsen | 2011 | Clinical Gastroenterology and Hepatology2011，，2： | 3 |
| 3 | CSF-adrenalinelow in ' somatizing depression ' 显示文摘 | Gjeris A Rafaelsen O J Christensen NJ | 1987 | Acta Psychiatr Scand1987，75，5： | 1 |
| 4 | Intraoperative ultra- sonography in detection of hepatic metastases from colorectal cancer 显示文摘 | Rafaelsen SR Kronborg O Larsen C | 1995 | Dis Colon Rectum1995，38，4： | 1 |
| 5 | Ultrasound imaging of flow patterns in liver metastases from colorectal cancer显示文摘 | Rafaelsen SR Solvig J | 2004 | Scand J Gastroenterol2004，39，8： | 1 |
| 6 | Lithium treatment and weightgain显示文摘 | Vendsborg PB Bech P Rafaelsen OJ | 1976 | ActaPsychiatr Scand1976，53，： | 1 |
| 7 | Diagnostic accuracy of capsule endoscopy for small bowel Crohn's disease is superior to that of MR enterography or CT enterography 显示文摘 | Jensen MD Nathan T Rafaelsen SR | 2011 | Clin Gastroen- terol Hepatol2011，9，2： | 1 |
| 8 | Exome se queneing reveals FAM20e mutations associated with /'ibro- blast growth factor 23-related hypophosphatemia, dental a- nomalies,and ectopic calcification显示文摘 | Rafaelsen SH Raeder H Fagerheim AK | 2013 | J Bone Miner Res2013，28，6： | 1 |
| 9 | Is there a difference in diagnostic accuracy and clinical impact between endoscopic ultrasonogra-phy and magnetic resonance cholangiopancreato graphy显示文摘 | Ainsworth AP Rafaelsen SR Wamberg PA | | 0，，： | 1 |
| 10 | Mini-com- pendium of rating scales for states of anxiety depression mania schizophrenia with corresponding DSM-~I syn- dromes显示文摘 | BECH P KASTRUP M RAFAELSEN OJ | 1986 | Acta Psychiatr Scand Suppl1986，326，： | 1 |
| 11 | Transrectal ultrasonography and magnetic resonance imaging in the staging of rectal cancer. Effect of experience显示文摘 | S? ren R. Rafaelsen Torben S? rensen Anders Jakobsen Claus Bisgaard Jan Lindebjerg | 2008 | Scandinavian Journal of Gastroenterology2008，，： | 1 |
| 12 | Gallstones and colorectal cancer-there is a relationship,but it is hardly due to cholecystectomy显示文摘 | Jorgensen T Rafaelsen S | 1992 | Dis Colon Rectum1992，35，： | 1 |
| 13 | Is there a difference in diagnostic accuracy and clinical impact between endoscopic ultrasonography and magnetic resonance cholangiopancreatography?显示文摘 | Ainsworth AP Rafaelsen SR Wamberg PA | 2003 | Endoscopy2003，35，12： | 1 |
| 14 | Dose-Effect Relationship in Chemoradiotherapy for Locally Advanced Rectal Cancer: A Randomized Trial Comparing Two Radiation Doses显示文摘 | Anders Jakobsen John Ploen Té Vuong Ane Appelt Jan Lindebjerg Soren R. Rafaelsen | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 15 | Diagnostic accuracies of MR enterography and CT enterography in symptomatic Crohn's disease显示文摘 | Jensen MD Kjeldsen J Rafaelsen SR | 2011 | Scand J Gastroenterol2011，46，： | 1 |
| 16 | Ultrasound imaging of flow patterns in liver metastases from colorectal cancer显示文摘 | Rafaelsen SR Slovig J | 2004 | Scand J Gastroenterol2004，39，： | 1 |
| 17 | Diagnostic accuracies of MR enterography and CT enterography in symptomatic Crohn' s disease 显示文摘 | Jensen MD Kjeldsen J Rafaelsen SR | 2011 | Scand J Gastroenterol2011，46，12： | 1 |
| 18 | Incidental findings at MRI-enterography in patients with suspected or known Crohn's disease显示文摘AIM:To determine the frequency and clinical impact of incidental findings detected with magnetic resonance imaging(MRI)-enterography in patients with suspected or known Crohn's disease(CD). METHODS:Incidental findings were defined as unexpected lesions outside the small intestine,not previously known or suspected at the time of referral, and not related to inflammatory bowel disease.Through a systematic review of medical charts we analyzed the clinical impact of incidental findings,and compared the MRI findings with subsequent diagnostic procedures. RESULTS:A total of 283 patients were included in the analysis,and MRI detected active CD in 31%,fistula in 1.4%and abscess in 0.7%.Extra-intestinal findings notrelated to CD were recorded in 72 patients(25%),of which 58 patients(20%)had 74 previously unknown lesions.Important or incompletely characterized findings were detected in 17 patients(6.0%).Incidental findings led to 12 further interventions in 9 patients(3.2%) revealing previously unknown pathological conditions in 5(1.8%).One patient(0.4%)underwent surgery and one patient was diagnosed with a malignant disease. MRI detected incidental colonic lesions in 16 patients of which additional work-up in 4 revealed normal anatomy. Two patients(0.7%)benefitted from the additional examinations,whereas incidental findings led to unnecessary examinations in 9(3.2%). CONCLUSION:In a minority of patients with suspected or known CD,important incidental findings are diagnosed at MRI-enterography.However,a substantial number of patients experience unnecessary morbidity because of additional examinations of benign or normal conditions. | Michael Dam Jensen Torben Nathan Jens Kjeldsen Sφren Rafael Rafaelsen | 2010 | World Journal of Gastroenterology2010，16，1： | 1 |
| 19 | Echo pattern of lymphnodes incolorectal cancer an in uitro study 显示文摘 | Rafaelsen SR KronborgO Fenger C | 1992 | Br J Radiol1992，65，： | 1 |
| 20 | Scandinavian journal of gastroenterology显示文摘 | Schreyer AG Kjeldsen J Rafaelsen SR etal | 2014 | 46(5):1449-14572014，46，5： | 1 |
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