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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Prospective Breast Cancer Risk Predicition Model for Women Undergoing Screening Mammography显示文摘 | William EB Emily W Rachel BB | 2006 | J Natl Cancer Inst2006，98，17： | 1 |
| 3 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | Rachel W Li G David Lin Stephen P Myers David N Leach | 2002 | Journal of Ethnopharmacology2002，，1： | 1 |
| 4 | Transcranial magnetic stimulation in psychiatric therapy显示文摘 | Zyss T Rachel W Datka W | 2015 | Przegl Lek2015，72，7： | 1 |
| 5 | Biomarkers of Alzheimer disease 显示文摘 | Rachel W Grela A Zyss T | 2014 | Przegl Lek2014，71，2： | 1 |
| 6 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate 显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 7 | Nephrotic syndrome in children显示文摘 | Rachel L Louise W Nicholas JAW | 2010 | Paediatrics and Child Health2010，20，1： | 1 |
| 8 | Evaluation the reinforcing effects of choice in comparison to reinforcement rate显示文摘 | Rachel H T Wayne W F Stephanie A C | 1998 | Research in Developmental Disabilities1998，19，2： | 1 |
| 9 | Surveillance for food-bome2 disease outbreaks - United States, 1998-2002显示文摘 | Michael L John P Rachel W | 2006 | MMWR2006，55，10： | 1 |
| 10 | The Scientific Attitude Inventory:A Revision(SAI Ⅱ)显示文摘 | | 1997 | Journal of Research In Science Teaching1997，34，4： | 1 |
| 11 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | LI RACHEL W DAVID LIN G MYERS STEPLEN P | 2003 | J E thnopharmacol2003，85，1： | 1 |
| 12 | Enteric gram-negative bacilli bloodstream infections: 17 years’ experience in a neonatal intensive care unit显示文摘 | Leandro Cordero Rachel Rau David Taylor Leona W Ayers | 2004 | AJIC: American Journal of Infection Control2004，，4： | 1 |
| 13 | Prevalence of Physical Activity Among Chinese Adults : Results From the International Collaborative Study of Cardiovascular Disease in Asia 显示文摘 | PAUL M DONFENG G RACHEL P W | 2005 | American Journal of Public Health2005，95，9： | 1 |
| 14 | Why did they do it : the conservatives and mass higher education 显示文摘 | DAVID W RACHEL B | 2006 | Journal of Education Policy2006，，5： | 1 |
| 15 | HIV~ elite controllers have low HIV specific T-cell activation yet maintain strong, polyfunctional T-cell responses显示文摘 | Rachel E Owen John W etal | 2010 | AIDS2010，24，8： | 1 |
| 16 | A 10 kDa structural protein of porcine reproductive and respiratory syndrome virus encoded by ORF2b 显示文摘 | Wu W H Fang Y Rachel F | 2011 | Virology2011，287，1： | 1 |
| 17 | Requirements capture theory and practice显示文摘 | RACHEL COOPER A B W | 1998 | Technovation1998，，18： | 1 |
| 18 | Bacterial population changes in a membrane bioreactor for graywater treatment monitored by denaturing gradient ge electrophoretic analysis of 16S rRNA gene fragments 显示文摘 | David M Stamper M W Rachel N J | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 19 | Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering显示文摘 | Jessica M W Adebisi Adewunmi Rachel M S | 2005 | Biomaterials2005，26，23： | 1 |
| 20 | Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control显示文摘 | Thanh Nguyen Joyce Obeid Rachel G Walker Matthew P Krause Thomas J Hawke Karen McAssey John Vandermeulen Brian W Timmons | 2015 | Pediatr Diabetes2015，，1： | 1 |
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