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| 1 | Immune response in COVID-19:addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2显示文摘To date,no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments.Therefore,based on the fast and global spread of the virus,urgent investigations are warranted in order to develop preventive and therapeutic drugs.In this regard,treatments addressing the immunopathology of SARS-CoV-2 infection have become a major focus.Notably,while a rapid and well-coordinated immune response represents the first line of defense against viral infection,excessive inflammatory innate response and impaired adaptive host immune defense may lead to tissue damage both at the site of virus entry and at systemic level.Several studies highlight relevant changes occurring both in innate and adaptive immune system in COVID-19 patients.In particular,the massive cytokine and chemokine release,the so-called“cytokine storm”,clearly reflects a widespread uncontrolled dysregulation of the host immune defense.Although the prospective of counteracting cytokine storm is compelling,a major limitation relies on the limited understanding of the immune signaling pathways triggered by SARS-CoV-2 infection.The identification of signaling pathways altered during viral infections may help to unravel the most relevant molecular cascades implicated in biological processes mediating viral infections and to unveil key molecular players that may be targeted.Thus,given the key role of the immune system in COVID-19,a deeper understanding of the mechanism behind the immune dysregulation might give us clues for the clinical management of the severe cases and for preventing the transition from mild to severe stages. | Michele Catanzaro Francesca Fagiani Marco Racchi Emanuela Corsini Stefano Govoni Cristina Lanni | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | Acetylcholinesterase inhibitors:novel activities of old molecules显示文摘 | Racchi M | | 0，，04： | 1 |
| 3 | Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease 显示文摘 | Lanni C Racchi M Stanga S | 2010 | J Alzheimers Dis2010，20，1： | 1 |
| 4 | Unfolded p53:a potential biomarker for Alzheimer's disease显示文摘 | Lanni C Uberti D Racchi M | 2007 | J Alzheimers Dis2007，12，1： | 1 |
| 5 | Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway显示文摘 | Solano DC Sironi M Bonfini C Solerte SB Govoni S Racchi M | 2000 | FASEB J2000，14，7： | 1 |
| 6 | Dehydroepiandrosterone (DHEA) and the aging brain:flipping a coin in the 'fountain of youth' 显示文摘 | Racchi M Balduzzi C Corsini E | 2003 | CNS Drug Rev2003，9，1： | 1 |
| 7 | Role of protein kinase C alpha in the regulated secretion of the amyloid precursor protein显示文摘 | Racchi M | 2003 | Mol Psychiatry2003，8，： | 1 |
| 8 | Dehydroepiandrosterone (DHEA) and the aging brain: flipping a coin in the 'fountain of youth'显示文摘 | Racchi M Balduzzi C Corsini E | 2003 | CNS Drug Rev2003，9，： | 1 |
| 9 | Developmental changes of catalase and superoxide dismutase isoenzymes in zygotic and so- matic embryos of horse chestnut显示文摘 | BAGNOLI F CAPUANA M RACCHI M L | 1998 | Australian Journal of Plant Physiology1998，25，8： | 1 |
| 10 | X Chromo some inactivation patterns in normal females显示文摘 | Mangerini R Rapezzi D | 1998 | Blood Cells Molecules and Diseases1998，24，21： | 1 |
| 11 | p53 at the crossroads between cancer and neurodegeneration显示文摘 | Larmi C Racchi M Memo M | 2012 | Free Radical Biology and Medicine2012，52，9： | 1 |
| 12 | Familial migraine with aura:association study with 5-HT1B/1 D,5-HT2C,and hSERT polymorphisms显示文摘 | Racchi M Leone M Porrello E | | 0，，04： | 1 |
| 13 | X-chromosome inactivation patterns in normal females显示文摘 | Racchi O Mangerini R Rapezzi D | 1998 | Blood Cells Molecules and Disease1998，24，： | 1 |
| 14 | Peripheral markers in testing pathophysiological hypotheses and diagnosing Alzheimer's disease显示文摘 | Gasparini L Racchi M Binetti G | | 0，，： | 1 |
| 15 | Familial migraine with aura : as- sociation study with 5-HT1B/1 D, 5-HT2C, and hSERT polymorphisms 显示文摘 | Racchi M Leone M Porrello E | 2004 | Headache2004，44，4： | 1 |
| 16 | p53 at the crossroads between cancer and neurodegeneration显示文摘 | Lanni C Racchi M Memo M | | 0，，09： | 1 |
| 17 | Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism 显示文摘 | Racchi M Govoni S | 1999 | Trends Pharmacol Sci1999，20，10： | 1 |
| 18 | Molecular regulations of circadian rhythm and implications for physiology and diseases显示文摘The term'circadian rhythms'describes endogenous oscillations with ca.24-h period associated with the earth’s daily rotation and light/dark cycle.Such rhythms reflect the existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt the internal environment with the external cues. | Francesca Fagiani Daniele Di Marino Alice Romagnoli Cristina Travelli Davide Voltan Lorenzo Di Cesare Mannelli Marco Racchi Stefano Govoni Cristina Lanni | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 19 | Amyloid beta antagonizes insulin promoted secretion of the amyloid beta-protein precursor显示文摘 | Ling X Martins RN Racchi M | 2002 | J Alzheimers Dis2002，4，5： | 1 |
| 20 | Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease显示文摘 | Brandi ML Becherini L Gennari L Racchi M | 1999 | Biochem-Biophys-res-commun1999，265，2： | 1 |
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