|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Evaluation of choroidal thickness using spectral-domain optical coherence tomography in patients with severe obstructive sleep apnea syndrome: a comparative study显示文摘AIM: To assess choroidal thickness in patients with severe obstructive sleep apnea syndrome(OSAS) and compare them with healthy controls, using spectral domain optical coherence tomography(OCT).METHODS: In this observational, cross-sectional study,choroidal thicknesses of 23 newly severe OSAS patients and 23 body mass index- age- and sex-matched healthy subjects were measured using a high-speed, high-resolution frequency domain- OCT device( λ = 840 nm,26 000 A-scans/s, 5 μm axial resolution). All patients underwent a complete ophthalmic examination before the measurements. OCT measurements were taken at the same time of day(9:00 a.m.), in order to minimize the effects of diurnal variation.RESULTS: There was a statistically significant difference in median choroidal thickness between the OSAS patients(201 μm; range 145-237 μm) and the controls(324 μm; range 296-383 μm;P <0.001). There were significant differences at all measurement points(P <0.001 for all). The apnea-hypopnea index(AHI)values were more than 30 in all OSAS patients and the mean AHI was 48.57 ±6.54. The interexaminer intraclass correlation coefficient(ICC) for the mean choroidal thickness was 0.938(95% CI, 0.908-0.985) and ICC was greater than 0.90 for all measurement points.CONCLUSION: The decreased choroidal thickness of patients with severe OSAS might be related to the the autonomic disregulation associated with this disease.Further studies are needed to evaluate the etiopathologic relationship between choroidal thickness and OSAS. | Aylin Karalezli Fatma Corak Eroglu Tulay Kivanc Rusina Dogan | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 2 |
| 3 | Photophysical Properties of Organic Fluorescent Probes on Nanosized TiO2/SiO2 Systems Prepared by the Sol-gel Method显示文摘 | Erenmnko A Smimova N Rusina O | 2000 | Journal of Molecular Structure2000，553，： | 1 |
| 4 | Manufacturing of biomorphic (Si, Ti, Zr)-earbide ceramics by sol-gel processing 显示文摘 | RAMBO CR CAO J RUSINA O | 2005 | Carbon2005，43，： | 1 |
| 5 | Diffusion coefficientsof polychlorinated biphenyls and polycyclic aromatic hydrocar-bons in polydimethylsiloxane and low - density polyethylene pol-ymers 显示文摘 | RUSINA T P SMEDES F KLANOVA J | 2010 | Journal of Applied Polymer Science2010，116，3： | 1 |
| 6 | Exogenous treatment with salicylic acid attenuates cadmium toxicity in pea seedlings显示文摘 | Losanka P P Liliana T M Rusina Y Y | 2009 | Plant Physiology and Biochemistry2009，47，： | 1 |
| 7 | Nitro- gen Photofixation at Nanostructured Iron Titanate Films显示文摘 | RUSINA O EREMENKO A FRANK G | 2001 | Angewandte Chemic International Edition2001，40，： | 1 |
| 8 | Manufacturing of biomorphic (Si,Ti,Zr)-carbide ceramics by sol gel processing显示文摘 | RAMBO CR CAO J RUSINA O | 2005 | Carbon2005，43，6： | 1 |
| 9 | Manufacturing of biomorphic(Si,Ti,Zr)-carbide ceramics by sol–gel processing显示文摘 | RAMBO C R CAO J RUSINA O | | 0，，06： | 1 |
| 10 | Manufacturing of biomorphic ( Si, Ti, Zr) -carbide ceramics by sol-gel processing显示文摘 | Rambo C R Cao J Rusina O | 2005 | Carbon2005，43，： | 1 |
| 11 | Synthesis and Characterization of Photocatalytic Porous Fe3+/TiO2 Layers on Glass显示文摘 | Natalie Smirnova Anna Eremenko Olga Rusina Werner Hopp Lubomir Spanhel | 2001 | Journal of Sol - Gel Science and Technology (-)2001，，1： | 1 |
| 12 | Manufacturing of biomorphic (Si, Ti, Zr)–carbide ceramics by sol–gel processing 显示文摘 | Rambo C R Cao J Rusina O | 2005 | Carbon2005，43，11： | 1 |
| 13 | Manufacturing of biomorphie (Si,Ti, Zr)-carbide ceramics by sol-gel processing 显示文摘 | Rambo C R C ao J Rusina O | 2005 | Carbon2005，43，： | 1 |
| 14 | Polymer selection for passive sampling:A comparison of critical properties显示文摘 | Rusina T P Smedes F Klanova J | | 0，，07： | 1 |
| 15 | Synthesis and characterization of photocatalytic porous Fe3 + /TiO2 layers on glass显示文摘 | Smirnova N Eremenko A Rusina O Hopp W | 2001 | Journal of Sol-Gel Science and Technology2001，21，： | 1 |
| 16 | Photophysical properties of organic fluorescent probes on nanosized TiO2-SiO2 systems prepared by the sol-gel method 显示文摘 | EREMENKO A SMIRNOVA N RUSINA O | 2000 | Journal of Molecular Structure2000，553，： | 1 |
| 17 | Predicted ultrafast dynamic metallization of dielectric nanofilms by strong single-cycle optical fields 显示文摘 | Maxim Durach Anastasia Rusina Matthias F Kling | 2011 | Phys Rev Left2011，107，08： | 1 |
| 18 | Manufacturing of biomorphic (si,ti,zr)-carbide ceramics by sol-gel processing显示文摘 | Rambo C R Cao J Rusina O | 2005 | Carbon2005，43，： | 1 |
| 19 | Flooding-in- duced changes in photosynthesis and oxidative status in maize plants 显示文摘 | Rusina Yordanova Yordanova Losanka Petrova Popova | 2007 | Acta Physiol Plant2007，29，： | 1 |
| 20 | Manufacturing of biomorphic (Si,Ti,Zr)-carbide ceramics by sol–gel processing显示文摘 | C.R. Rambo J. Cao O. Rusina H. Sieber | 2005 | Carbon2005，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员