|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The mitochondrial genome encodes abundant small noncoding RNAs显示文摘识别的小 noncoding RNA 都被原子染色体远因此编码。这里,我们主要报导鼠科、人的 mitochondrial 染色体编码几千小 noncoding RNA,它是源于 mitochondrial 基因(主人基因) 的感觉抄本,并且我们称为这些小 RNA mitochondrial 编码染色体的小 RNA (mitosRNAs ) 。影响的 DICER inactivation,但是完全没废除 mitosRNA 生产。MitosRNAs 看起来是当前未辩别出的 mitochondrial ribonucleases 的产品。提高的表示在 vitro 他们的主人基因铺平的 mitosRNAs 的 Overexpression,和 dysregulated mitosRNA 表示通常在 vivo 与异常 mitochondrial 基因表示被联系。我们的数据证明除了 37 已知的 mitochondrial 基因,哺乳动物的 mitochondrial 染色体也编码丰富的 mitosRNAs,它可以在房间在 mitochondrial 基因表示的控制起一个重要规章的作用。 | Seungil Ro Hsiu-Yen Ma Chanjae Park Nicole Ortogero Rui Song Grant W Hennig Huili Zheng Yung-Ming Lin2 Loredana Moro Jer-Tsong Hsieh wei Yant | 2013 | Cell Research2013，23，6： | 3 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Altered L-type Ca^2 + channel currents in vascular smooth muscle ceils from experimental diabetic rats显示文摘 | Rui W Yuejin W Guanghua T | 2000 | Am J Physiol2000，278，3： | 1 |
| 4 | Two's company, three's a crowd: Can H2S be the third endogenous gaseous transmitter? 显示文摘 | Rui W | 2002 | FASEB J2002，16，13： | 1 |
| 5 | A new and simple method for concentration of enteric viruses from water显示文摘 | LI J W WANG X W Qi Yi Rui | 1998 | Journal of Virological Methods1998，，74： | 1 |
| 6 | Effects of acute stress]on blood dotting and yeast killing by phagocytes of rainbow trout显示文摘 | RUIS M A W BAYNE C J | 1997 | Journal of Aquatic Animal Health1997，9，： | 1 |
| 7 | Why Can the Carbon Nanotube Tips Increase Resolution and Quality of Image in Biological Systems 显示文摘 | Guo L Q Rui W Xu H M | 2005 | Physica E2005，27，12： | 1 |
| 8 | Integral Bifurcation Method and Its Application for Solving the Modified Equal Width Wave Equation and Its Variants显示文摘 | Rui W G Xie Sh L Long Y | 2007 | Rostock Math Kolloq2007，62，： | 1 |
| 9 | Analysis of dynamic chemicalchanges in Chinese Cantonese sausage:Factors influencing contentof nitrite and formation of flavor substances 显示文摘 | Chen W Rui H Yuan H ef al | 2007 | Journal of FoodEngineering2007，79，4： | 1 |
| 10 | Characterization of a novel exopolysaccharide with antitumor activity from Laetobacillus plantarum 70810显示文摘 | Wang K Li W Rui X | 2014 | International Journal of Biological Macromolecules2014，63，： | 1 |
| 11 | Ownership and the value of political connections:evidence from China显示文摘 | WU W WU C RUI O M | 2010 | European Financial Management2010，10，111： | 1 |
| 12 | Inhibition of pro-inflammato- ry cytokines in tumor associated macrophages is a potential anti-cancer mechanism of carboxyamidotriazole显示文摘 | Rui J Danwei W Lei G | 2011 | Eur J Cancer2011，48，7： | 1 |
| 13 | Hand-arm vibration syndrome and upper limb disorders associated with forestry work 显示文摘 | Bovenzi M Rui F Versini W | 2004 | Med Lay2004，95，4： | 1 |
| 14 | The effects of political connections and state ownership on corporate litigation in China显示文摘 | Firth M Rui O M Wu W | 2011 | Journal of Law and Economics2011，54，3： | 1 |
| 15 | Recent Trends in Research of SARS Coronavirus Genome, Protein and Course of Invasion into Host Cell显示文摘 | Rui W Zhang Q P Shi L Lu M | 2003 | Chinese Med J2003，83，： | 1 |
| 16 | Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients 显示文摘 | Xi W Rui W Fang L | 2009 | J Cancer Res Clin Oncol2009，135，： | 1 |
| 17 | In situ intestinal absorption behaviors of tanshinone ⅡA from its inclusion complex with hydroxypropyl beta-cyclodextrin显示文摘 | Ling W Rui L C Hua J X | 2007 | Biol Pharm Bull2007，30，： | 1 |
| 18 | Some new travelling wave solutions with singular or nonsingular character for the higher order wave equation of KdV type (Ⅲ) 显示文摘 | RUI W LONG Y HE B | 2009 | Nonlinear Analysis2009，70，： | 1 |
| 19 | Bakkenolides from Petasites tatewakianus显示文摘 | Xie W D Rui J L Xue G | 2010 | Fitoterapia2010，81，： | 1 |
| 20 | The integral bifurcation method and its application for solving a family of third-order dispersive PDEs 显示文摘 | RUI W HE B LONG Y | 2008 | Nonlinear Analysis2008，69，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员