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| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 3 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 4 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
| 5 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 6 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | 2012 (9859)2012，，9859： | 2 |
| 7 | Toxicity of pesticides to aquatic microorganisms: a review显示文摘 | Delorenzo M E Scott G I Ross P E | 2001 | Environ Toxicol Chem2001，20，1： | 2 |
| 8 | Diet and fecal lipids following cholecystectomy in men显示文摘 | BRYDON W G ROSS M C L ANDERSON J R | 1982 | Digestion1982，25，： | 1 |
| 9 | Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA显示文摘 | ROSS R J SWEENEY M G | 1992 | Lancet1992，340，： | 1 |
| 10 | Disease dynamics of Montipora white syndrome within Kaneohe Bay, Oahu, Hawaii: distri- bution,seasonality,virulenee,and transmissibility显示文摘 | AEBY G S ROSS M WILLIAMS G J | 2010 | Diseases of Aquatic Organisms Dis Aquat Org2010，91，： | 1 |
| 11 | Using the OSCE tomeasure clinical skills performance in nursing显示文摘 | Ross M Carroll G Knight J | | 0，，01： | 1 |
| 12 | Largeand growing environmental reservoirs of Deca-BDE presentan emerging health risk for fish and marine mammals显示文摘 | Ross P S Couillard C M Ikonomou M G | 2009 | Marine Pollution Bulletin2009，58，1： | 1 |
| 13 | Urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People' s republic of China 显示文摘 | QIAN G S YU M C ROSS R | 1994 | Cancer Epidemiol Biomarkers Prey1994，3，： | 1 |
| 14 | Photoperiod regulates arcuate nucleus POMC, AGRP, and Leptin receptor mRNA in siberian hamster hypothalamus显示文摘 | Mercer J G Moa K M Ross A W | 2000 | American Journal Physiology Regulatory Integrative and Comparative Physiology2000，278，1： | 1 |
| 15 | The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle显示文摘 | Qiu G H Salto-Tellez M Ross J A | 2008 | J Hepatol2008，48，3： | 1 |
| 16 | Activation of the Oryza sativa non-symbiotic haemoglobin-2 promoter by the cytokinin-regulated transcription factor, ARR1 显示文摘 | Ross E J Stone J M Elowsky C G | 2004 | Journal of Experimental Botany2004，55，403： | 1 |
| 17 | DNA surveillance: web-based molecular identification of whales, dolphins, and porpoises显示文摘 | Ross H A Lento G M Dalebout M L | 2003 | J Hered2003，94，2： | 1 |
| 18 | Knowledge management in research and development显示文摘 | Armbrecht Jr.F M Ross Chappelow C C Farris G F | | 0，，04： | 1 |
| 19 | Electrospray ionization of alkali and alkaline earth metal species显示文摘 | Ross R S Ikonomou M G Orians K J | 2000 | J Mass Spectrom2000，35，： | 1 |
| 20 | Geological controls on matrix permeability of Devonian Gas Shales in the Horn River and Liard basins, northeastern British Columbia, Cmada 显示文摘 | Chalmers G R L Ross D J K Bustin R M | 2012 | International Journal of Coal Geology2012，103，： | 1 |
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