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| 1 | 急性下呼吸道感染儿童的维生素D摄入显示文摘目的明确维生素D(Vit D)摄入是否与儿童急性下呼吸道感染(ALRI)相关。方法比较因毛细支气管炎或肺炎入院的5岁以下儿童和非配对、无呼吸道感染的同龄对照组儿童之间Vit D摄入的差别。197例儿童的看护人完成了问卷调查,内容包括人口统计变量、ALRI危险因素和饮食。评估ALRI与Vit D摄入及其他危险因素的相关性。结果 ALRI组儿童的平均Vit D摄入为每日48 IU/kg,对照组为每日60 IU/kg。当控制年龄、民族、社会经济地位、北部地区居住、母乳喂养、免疫接种和接触吸烟等因素时,Vit D每日摄入<80 IU/kg的儿童患ALRI的可能性比每日摄入≥80 IU/kg的儿童高4倍(OR=4.9;95%CI:1.5~16.4)。结论为了避免罹患ALRI等疾病,5岁以下儿童可能需要摄入比现在推荐量更高的Vit D剂量。因毛细支气管炎和肺炎是年幼儿童住院的最常见原因,增加Vit D的补充可能有重要的公共卫生保健意义。 | Karen S Leis J Dayre McNally Matthew R Montgomery Koravangattu Sankaran Chandima Karunanayake Alan M Rosenberg 马丽亚(译) | 2012 | 中国当代儿科杂志2012，14，1： | 25 |
| 2 | 社会经济及环境因子对不同收入群体自评健康的影响显示文摘对健康影响因素的干预是将'健康中国'战略落实到实处的重点,而深入探究健康的影响因子是实施有效干预的前提。结合中国当前工业化、环境退化及收入差距扩大化的背景,基于中国综合社会调查2013年数据,采用多层次Logistic回归分析模型,从个体、社区及省级三个层次,深入解析社会经济及环境因子对较低、中等及较高收入群体自评健康状况的影响。结果表明:(1)个体与地方特征对自评健康有不同程度的影响。个体特征的解释力最强,省级因子解释力最弱。(2)社会经济因子对健康的作用在不同收入群体间差异很大。通常被认为是有益于健康的因子如收入、教育水平、政府服务等仅对中低等收入群体有显著作用。(3)环境因子与健康呈正相关性,且此相关性对较高收入群体最强。(4)环境污染可以抵消一部分社会经济发展的健康促进作用。(5)除了不平等的社会经济条件,环境不公正是导致健康不公平的另一重要原因。 | 顾丽娟 Mark ROSENBERG 曾菊新 | 2017 | 地理研究2017，36，7： | 22 |
| 3 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 4 | 上海市慢性乙型肝炎自然史的回顾性队列研究显示文摘目的 研究上海市慢性乙型肝炎病人的慢性乙型肝炎自然史。方法 以回顾性队列研究的方式 ,比较 1981~ 1993年确诊的 32 2例慢性乙型肝炎有肝硬化者和无肝硬化者的失代偿性肝硬化发生率、肝癌发生率、生存率以及两组对象死于肝癌、肝脏疾病和全死因的标化死亡率比 (SMR)。结果 无肝硬化组和有肝硬化组的人年病死率分别为 7 6‰和 35 2‰ ,肝癌人年发生率依次为 2 8‰和 8 2‰ ,失代偿性肝硬化人年发生率分别为 6 7‰和 35 6‰。SMR分析两组对象全死亡率、肝癌和肝脏疾病病死率均高于上海市一般人群 ,尤以有肝硬化组为甚。结论 上述队列中有肝硬化组的生存率、不发生失代偿性肝硬化率显著低于无肝硬化组 ,两组慢性乙型肝炎患者死于肝癌。 | 徐飚 胡德昌 Daniel Rosenberg 姜庆五 林曦敏 陆嘉良 李旭亮 | 2002 | 中华内科杂志2002，41，6： | 17 |
| 5 | Inflammation and fibrosis in chronic liver diseases including nonalcoholic fatty liver disease and hepatitis C显示文摘At present chronic liver disease(CLD),the third commonest cause of premature death in the United Kingdom is detected late,when interventions are ineffective,resulting in considerable morbidity and mortality.Injury to the liver,the largest solid organ in the body,leads to a cascade of inflammatory events.Chronic inflammation leads to the activation of hepatic stellate cells that undergo transdifferentiation to become myofibroblasts,the main extra-cellular matrix producing cells in the liver;over time increased extra-cellular matrix production results in the formation of liver fibrosis.Although fibrogenesis may be viewed as having evolved as a“wound healing”process that preserves tissue integrity,sustained chronic fibrosis can become pathogenic culminating in CLD,cirrhosis and its associated complications.As the reference standard for detecting liver fibrosis,liver biopsy,is invasive and has an associated morbidity,the diagnostic assessment of CLD by non-invasive testing is attractive.Accordingly,in this review the mechanisms by which liver inflammation and fibrosis develop in chronic liver diseases are explored to identify appropriate and meaningful diagnostic targets for clinical practice.Due to differing disease prevalence and treatment efficacy,disease specific diagnostic targets are required to optimally manage individual CLDs such as non-alcoholic fatty liver disease and chronic hepatitis C infection.To facilitate this,a review of the pathogenesis of both conditions is also conducted.Finally,the evidence for hepatic fibrosis regression and the mechanisms by which this occurs are discussed,including the current use of antifibrotic therapy. | Sudeep Tanwar Freya Rhodes Ankur Srivastava Paul M Trembling William M Rosenberg | 2020 | World Journal of Gastroenterology2020，26，2： | 17 |
| 6 | Model for end-stage liver disease score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis显示文摘AIM:To determine factors affecting the outcome of patients with cirrhosis undergoing surgery and to compare the capacities of the Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD)score to predict that outcome. METHODS:We reviewed the charts of 195 patients with cirrhosis who underwent surgery at two teaching hospitals over a five-year period.The combined endpoint of death or hepatic decompensation was considered to be the primary endpoint. RESULTS:Patients who reached the endpoint had a higher MELD score,a higher CTP score and were more likely to have undergone an urgent procedure.Among patients undergoing elective surgical procedures,no statistically significant difference was noted in the mean MELD(12.8±3.9 vs 12.6±4.7,P=0.9)or in the mean CTP(7.6±1.2 vs 7.7±1.7,P=0.8)between patients who reached the endpoint and those who did not.Both mean scores were higher in the patients reaching the endpoint in the case of urgent procedures(MELD:22.4± 8.7 vs 15.2±6.4,P=0.0007;CTP:9.9±1.8 vs 8.5±1.8, P=0.008).The performances of the MELD and CTP scores in predicting the outcome of urgent surgery were only fair,without a significant difference between them (AUC=0.755±0.066 for MELD vs AUC=0.696±0.070 for CTP,P=0.3). CONCLUSION:The CTP and MELD scores performedequally,but only fairly in predicting the outcome of urgent surgical procedures.Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with cirrhosis. | Maarouf A Hoteit Amaar H Ghazale Andrew J Bain Eli S Rosenberg Kirk A Easley Frank A Anania Robin E Rutherford | 2008 | World Journal of Gastroenterology2008，14，11： | 16 |
| 7 | 聚烯丙基胺硅胶复合材料的合成及其吸附性能显示文摘利用氯丙基三氯硅烷与硅胶表面羟基反应制备了烷基化硅胶 (CPTCS 硅胶 ) ,所得产物与聚烯丙基胺 (PAA 15 )反应合成了PAA 硅胶复合材料。测定了PAA 硅胶复合材料的FTIR光谱、胺基含量和润湿角 ,考察了溶液 pH值、吸附时间和吸附温度对其吸附性能的影响 ,得到在 2 5℃、pH =3 5条件下 ,复合材料对Cu2 + 的吸附容量为 0 85mmol/g ;当 pH =4 0时 ,对Pb2 + 的吸附容量可达到 0 5 3mmol/g。结果表明 ,PAA 硅胶复合材料吸附性能优良 ,是一处良好的吸附材料。 | 范忠雷 李殿卿 Edward Rosenberg | 2003 | 应用化学2003，20，9： | 13 |
| 8 | Colorectal carcinogenesis-update and perspectives显示文摘Colorectal cancer(CRC)is a very common malignancy in the Western World and despite advances in surgery,chemotherapy and screening,it is still the second leading cause of cancer deaths in this part of the world.Numerous factors are found important in the development of CRC including colonocyte metbolism,high risk luminal environment,inflammation,as well as lifestyle factors such as diet,tobacco,and alchohol consumption.In recent years focus has turned towards the genetics and molecular biology of CRC and several interesting and promising correlations and pathways have been discovered.The major genetic pathways of CRC are the Chromosome Instability Pathway representing the pathway of sporadic CRC through the K-ras,APC,and P53 mutations,and the Microsatellite Instability Pathway representing the pathway of he re di t ar y non-polyposis c olon c anc e r t hrough mutations in mismatch repair genes.To identify early cancers,screening programs have been initiated,and the leading strategy has been the use of faecal occult blood testing followed by colonoscopy in positive cases.Regarding the treatment of colorectal cancer,significant advances have been made in the recent decade.The molecular targets of CRC include at least two important cell surface receptors:the epidermal growth factorreceptor and the vascular endothelial growth factor receptor.The genetic and molecular knowledge of CRC has widen the scientific and clinical perspectives of diagnosing and treatment.However,despite significant advances in the understanding and treatment of CRC,results from targeted therapy are still not convincing.Future studies will determine the role for this new treatment modality. | Hans Raskov Hans-Christian Pommergaard Jakob Burcharth Jacob Rosenberg | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 9 | 骨原发Rosai-Dorfman病:15例临床病理分析显示文摘 | Demicco E G Rosenberg A E Bjrnsson J 郎志强 | 2010 | 临床与实验病理学杂志2010，26，5： | 10 |
| 10 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 11 | 富营养化对海底系统污染物循环的影响显示文摘本文研究了有机物质输入对波罗的海和卡特加特海峡海底生态系统疏水性有机污染物(HOC)生物利用度和循环的影响。通过实验,我们研究了由于紫胎贝(Mytilus edulis)、蛇尾虫(Amphiura filiformis)及多毛目环节动物(Nereis diversicolor)所引起的微藻增加对HOC(PCB和PAH)生物积累的影响。和平衡分配理论相反,生物积累与海藻和有机碳的浓度成正比。这是由海藻有机碳中营养质量高所造成的,同时也表明是取食而不是平衡分配控制了这些物种的生物积累。通过实地研究,我们估计了紫贻贝和蛇尾虫体内每年PCB的流通总量和每年转移到更高营养级的污染物的总量。研究结果指出:①富营养化能促进底栖生物体内HOC的积累。②在评价海底系统污染时,必需考虑有机碳质量和数量在时间上的变化。③大型动物的取食活动对海底和深海结合IIOC很重要。④生物扰动促进了HOC从沉积物向水面的释放。 | Jonas Gunnarsson Mikael Bjrk Michael Gilek Maria Granberg Rutger Rosenberg 王燕 | 2000 | AMBIO-人类环境杂志2000，29，4： | 4 |
| 12 | Collagenase-Induced Intracerebral Hemorrhage in Rats显示文摘 | Gary A. Rosenberg Sheila Mun-Bryce Mary Wesley Mario Kornfeld | 1990 | Stroke1990，，5： | 4 |
| 13 | Effects of Bone Cement Volume and Distribution on Vertebral Stiffness After Vertebroplasty显示文摘 | Michael A.K. Liebschner William S. Rosenberg Tony M. Keaveny | 2001 | Spine2001，，14： | 3 |
| 14 | 不确定性与创新文化显示文摘 1
在考虑科学和技术文化时,有一个在讨论中起支配作用的关键词,即不确定性.当在科学和技术领域进行研究时,其研究结果不可能事先预测,简单的现实是,当必须获得并不可利用的信息时,研究仍在进行.但是,由于各种原因,大多数高技术领域的研究并没有带来有商业价值的发现.…… | Nathan Rosenberg 宋建元 | 2001 | 自然辩证法研究2001，17，z1： | 3 |
| 15 | Adoptive cell therapy for the treatment of patients with metastatic melanoma显示文摘 | Steven A Rosenberg Mark E Dudley | 2009 | Current Opinion in Immunology2009，，2： | 3 |
| 16 | Treating cancer with genetically engineered T cells显示文摘 | Tristen S. Park Steven A. Rosenberg Richard A. Morgan | 2011 | Trends in Biotechnology2011，，11： | 3 |
| 17 | Access to residential care in Beijing, China: making the decision to relocate to a residential care facility显示文摘 | YANG CHENG MARK W. ROSENBERG WUYI WANG LINSHENG YANG HAIRONG LI | 2011 | Ageing and Society2011，，8： | 3 |
| 18 | 白细胞介素2免疫治疗癌症的现状与展望显示文摘从带瘤宿主中分离的淋巴因子激活的杀伤(LAK)细胞,经体外培养于白细胞介素2(IL-2)进行选择扩增后可作为肿瘤特异性杀伤细胞。动物实验和临床试验表明,将这些非主要组织相容性(MHC)限制的杀伤细胞过继转移到带瘤宿主,可使所选患者的癌症消退。本文详述了作者进行的LAK细胞的治疗研究,并指出如何能够提高迄今所取得的临床效益。 | Rosenberg SA 俞慕华 | 1989 | 国外医学(预防.诊断.治疗用生物制品分册)1989，12，1： | 3 |
| 19 | Collagenase induced intracerebral hemorrhage in rats显示文摘 | Rosenberg G A Mun Bryce S Wesley M | 1990 | Stroke1990，21，5： | 2 |
| 20 | 水生生态系统的富营养化和污染物显示文摘富营养化和长效污染物是欧洲海洋和淡水生态系统存在的主要环境问题。由于它们趋于共同产生,所以富营养化和污染物之间就有了相互作用,因而无法根据它们各自独立的作用过程来预测它们共同导致的环境影响。为了预测防治措施(改变有机质、营养物和污染物的输入)的效果,认识改变生物可利用性和污染物的迁移转化的机制是非常重要的。环境风险取决于污染物的种类形成和它们与媒介及其物质间的联系,并以此影响暴露程度。而且,风险也将取决于物质的流动性和它们在食物链中的路径。1995年,瑞典环境保护局发起了一项为期5年的研究项目'富营养化和污染物之间的相互作用(EUCON)'。前期准备的有关背景资料罗列了大量相关的问题和假设。在这些资料的基础上,项目开始启动,主要致力于海洋环境研究,重点集中在波罗的海及湖泊的富营养化和污染物(持续性有机化合物和微量金属)的相互作用上。本文总结了该项目研究的现状、前提和重点部分,强调了研究结果的应用及其意义。 | Jens Skei Per Larsson Rutger Rosenberg Per Jonsson Mats Olsson Dag Broman 鲁春霞 | 2000 | AMBIO-人类环境杂志2000，29，4： | 2 |
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