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| 1 | Obesity and colorectal cancer:Role of adipokines in tumor initiation and progression显示文摘Obesity-associated diseases account for a large portion of public health challenges.Among obesity-related disorders,a direct and independent relationship has been ascertained for colorectal cancer(CRC).The evidence that adipocyte hypertrophy and excessive adipose tissue accumulation(mainly visceral)can promote pathogenic adipocyte and adipose tissue-related diseases,has led to formulate the concept of'adiposopathy',defined as adipocyte and adipose tissue dysfunction that contributes to metabolic syndrome.Adipose tissue can,indeed,be regarded as an important and highly active player of the innate immune response,in which cytokine/adipokine secretion is responsible for a paracrine loop between adipocytes and macrophages,thus contributing to the systemic chronic low-grade inflammation associated with visceral obesity,which represents a favorable niche for tumor development.The adipocyte itself participates as a central mediator of this inflammatory response in obese individuals by secreting hormones,growth factors and proinflammatory cytokines,which are of particular relevance for the pathogenesis of CRC.Among adipocyte-secreted hormones,the most relevant to colorectal tumorigenesis are adiponectin,leptin,resistin and ghrelin.All these molecules have been involved in cell growth and proliferation,as well as tumor angiogenesis and it has been demonstrated that their expression changes from normal colonic mucosa to adenoma and adenocarcinoma,suggesting their involvement in multistep colorectal carcinogenesis.These findings have led to the hypothesis that an unfavorable adipokine profile,with a reduction of those with an anti-inflammatory and anti-cancerous activity,might serve as a prognostic factor in CRC patients and that adipokines or their analogues/antagonists might become useful agents in the management or chemoprevention of CRC. | Silvia Riondino Mario Roselli Raffaele Palmirotta David Della-Morte Patrizia Ferroni Fiorella Guadagni | 2014 | World Journal of Gastroenterology2014，20，18： | 20 |
| 2 | Targeted therapy in first line treatment of RAS wild type colorectal cancer显示文摘The debate on the optimal drug combination for treating chemotherapy-nave patients with metastatic colorectal cancer has recently become particularly heated.The present editorial will review recent data on this topic.The FIRE-3 and PEAK trials have shown a 7.5 to 12 mo survival advantage with the use anti-epidermal growth factor receptor(anti-EGFR)antibodies.The CALGB 80405 has shown no difference between anti-EGFR and anti-vascular endothelial growth factor agents.All three trials have consistently shown a significant increase in objective response rate.These data suggest that there is a subset of metastatic colorectal cancer patients,rigorously selected by molecular profiling,who particularly benefit from an anti-EGFR-based regimen in the first-line setting. | Vincenzo Formica Mario Roselli | 2015 | World Journal of Gastroenterology2015，21，10： | 6 |
| 3 | Immune reaction and colorectal cancer:Friends or foes?显示文摘The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid tumors.Colorectal cancer is one of the most studied neoplasms for the tumor-host immunity relationship.Although immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified,still no approved therapies based on host immunity intensification have so far been introduced in clinical practice.Moreover,a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this approach.The aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease. | Vincenzo Formica Vittore Cereda Antonella Nardecchia Manfredi Tesauro Mario Roselli | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 4 | Peripheral CD45RO, PD-1, and TLR4 expression in metastatic colorectal cancer patients treated with bevacizumab, fluorouracil, and irinotecan (FOLFIRI-B)显示文摘 | Vincenzo Formica Vittore Cereda Maria-Giovana Bari Italia Grenga Manfredi Tesauro Palmirotta Raffaele Patrizia Ferroni Fiorella Guadagni Mario Roselli | 2013 | Medical Oncology2013，，4： | 2 |
| 5 | Association between serum carcinoembryonie antigen and endothelial cell adhesionmolecules in colorectal cancer显示文摘 | Roselli M Guadagni F Martini F | 2003 | Oncology2003，65，2： | 1 |
| 6 | A study of organic films formed in the Fe/H2SO4+propargyl alcohol system by UV and IR spectroscopy and electron and X-ray diffraction显示文摘 | Roselli M E Sanchez M A Macci E M Podesta J J | 1990 | CormsSci1990，30，： | 1 |
| 7 | Pulmonary hypertension is associated with worse early and late outcomes after aortic valve replacement:implications for transcatheter aortic valve replacement显示文摘 | Roselli EE Abdel Azim A Houghtaling PL | | 0，，05： | 1 |
| 8 | Early glomerular filtration defect and severe renal disease in podocin-deficient mice显示文摘 | Roselli S Heidet L Sich M | 2004 | Mol Cell Biol2004，24，2： | 1 |
| 9 | We should replace the aortic arch and more in DeBakey type I dissection-A perspective from the Cleveland Clinic 显示文摘 | Roselli EE | 2013 | Ann Cardiothorac Surg2013，2，2： | 1 |
| 10 | Surgical advances in heart and lung transplantation 显示文摘 | Roselli EE Smedira NG | 2004 | Anesthesiol Clin North America2004，22，4： | 1 |
| 11 | Podocin lo- the kidney to the slit diaphragm area显示文摘 | Roselli S Gribouvai O Boute N | 2002 | Am J Pathol2002，160，1： | 1 |
| 12 | Novel High-Sensitive D-Dimer Determination Predicts Chemotherapy-Associated Venous Thromboembolism in Intermediate Risk Lung Cancer Patients显示文摘 | Patrizia Ferroni Francesca Martini Ilaria Portarena Gioia Massimiani Silvia Riondino Francesca La Farina Sabrina Mariotti Fiorella Guadagni Mario Roselli | 2012 | Clinical Lung Cancer2012，，6： | 1 |
| 13 | Early glomerular filtration defect and severe renal disease in podocin-deftcient mice 显示文摘 | ROSELLI S HEIDET L SICH M | 2004 | Mol Cell Biol2004，24，2： | 1 |
| 14 | TAG-72(CA72-4 assay) as a complementary serum tumor antigen to carcinoembryonic antigen in monitoring patients with colorectal cancer 显示文摘 | Guadagni F Roselli M Cosimelli M | 1993 | Cancer1993，72，： | 1 |
| 15 | Contrast-enhanced MR mammography forevaluation of the contralateral breast inpatients with diagnosed unilateral breastcancer or high-risk lesions显示文摘 | Pediconi F Catalano C Roselli A | 2007 | Radiology2007，243，3： | 1 |
| 16 | Least energy nodal solutions of the Brezia-Nirenberg problem in dimension N =5显示文摘 | Roselli P Willem M | 2009 | Comm Contemp Math2009，，1： | 1 |
| 17 | Lactobacillus amylovorus inhibits the TLR4 inflammatory signaling triggered by enterotoxigenic Escherichia coli via modulation of the negative regulators and involvement of TLR2 in intestinal Caco-2 cells and pig explants显示文摘 | FINAMORE A ROSELLI M IMBINTO A | 2014 | PLoS One2014，9，94： | 1 |
| 18 | Probiotic bacteria Bifidobacterium animalis MB5 and Lactobacillus rhamnosus GG protect intestinal Caco-2 cells from the inflammation-associated response induced by enterotoxigenic Escherichia coli K88显示文摘 | ROSELLI M FINAMORE A BRITTI M S | | 0，，06： | 1 |
| 19 | Endovascular stent grafting for ascending aorta repair in high-risk patients 显示文摘 | Roselli EE Idrees J Greenberg RK | 2015 | J Thorac Cardiovasc Surg2015，149，： | 1 |
| 20 | In vivo evaluation of bismuth-labeled monoelonal antibody comparing DTPA-derived bifunctional chelates显示文摘 | MILENIC D E ROSELLI M MIRZADEH S | 2001 | Radiopharrn2001，16，： | 1 |
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