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| 1 | Advances in immunotherapy for treatment of lung cancer显示文摘Different approaches for treating lung cancer have been developed over time, including chemotherapy, radiotherapy and targeted therapies against activating mutations. Lately, better understanding of the role of the immunological system in tumor control has opened multiple doors to implement different strategies to enhance immune response against cancer cells. It is known that tumor cells elude immune response by several mechanisms. The development of monoclonal antibodies against the checkpoint inhibitor programmed cell death protein 1(PD-1) and its ligand(PD-L1), on T cells, has led to high activity in cancer patients with long lasting responses. Nivolumab, an anti PD-1 inhibitor, has been recently approved for the treatment of squamous cell lung cancer patients, given the survival advantage demonstrated in a phase III trial. Pembrolizumab, another anti PD-1 antibody, has received FDA breakthrough therapy designation for treatment of non-small cell lung cancer(NSCLC), supported by data from a phase I trial. Clinical trials with anti PD-1/PD-L1 antibodies in NSCLC have demonstrated very good tolerability and activity, with response rates around 20% and a median duration of response of 18 months. | Jean G.Bustamante Alvarez María González-Cao Niki Karachaliou Mariacarmela Santarpia Santiago Viteri Cristina Teixidó Rafael Rosell | 2015 | Cancer Biology & Medicine2015，12，3： | 22 |
| 2 | Human endogenous retroviruses and cancer显示文摘Human endogenous retroviruses(HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution. About 8% of our genome is composed of HERVs, most of which are nonfunctional because of epigenetic control or deactivating mutations. However, a correlation between HERVs and human cancer has been described and many tumors, such as melanoma, breast cancer, germ cell tumors, renal cancer or ovarian cancer, express HERV proteins, mainly HERV-K(HML6) and HERV-K(HML2). Although the causative role of HERVs in cancer is controversial, data from animal models demonstrated that endogenous retroviruses are potentially oncogenic. HERV protein expression in human cells generates an immune response by activating innate and adaptive immunities. Some HERV-derived peptides have antigenic properties. For example, HERV-K(HML-6) encodes the HER-K MEL peptide recognized by CD8+ lymphocytes. In addition, HERVs are twoedged immunomodulators. HERVs show immunosuppressive activity. The presence of genomic retroviral elements in host-cell cytosol may activate an interferon type I response. Therefore, targeting HERVs through cellular vaccines or immunomodulatory drugs combined with checkpoint inhibitors is attracting interest because they could be active in human tumors. | María Gonzalez-Cao Paola Iduma Niki Karachaliou Mariacarmela Santarpia Julià Blanco Rafael Rosell | 2016 | Cancer Biology & Medicine2016，13，4： | 3 |
| 3 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 4 | Variability of the mitochondrial control region in populations of the harbour porpoise, Phocoena phocoena, on interoceanic and regional scales 显示文摘 | Rosel P E Dizon A E Haygood M G | 1995 | Can J Fish Aquat Sci1995，52，： | 2 |
| 5 | Different hydrocolloids as bread improvers and antistaling agents显示文摘 | A Guarda C.M Rosell C Benedito M.J Galotto | 2003 | Food Hydrocolloids2003，，2： | 2 |
| 6 | Nueleotide excision repair pathways involved in Cisplatin resistance in non-small-cell lung cancer显示文摘 | ROSELL R TARON M BARNADAS A | 2003 | Cancer Control2003，10，4： | 1 |
| 7 | Influence of hydrocolloids on dough rheology and bread quality 显示文摘 | ROSELL C M ROJAS J A DE BARBER C B | 2001 | Food Hydrocolloids2001，15，1： | 1 |
| 8 | Nucleotide excision repair psthways involved in cisplatin resistance in non-small-cell lung cancer显示文摘 | Rosell R Taron M Barnadas A | | 0，，： | 1 |
| 9 | Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR expressing advanced non-small-cell lung cancer显示文摘 | Rosell R Robinet G Szezesna A | 2008 | Ann Oncol2008，19，2： | 1 |
| 10 | Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke 显示文摘 | ROSELL A ORTEGA-AZNAR A ALVAREZ- SABIN J | 2006 | Stroke2006，37，6： | 1 |
| 11 | Different hydrocolloids as bread improvers and antistaling agents 显示文摘 | GUARDA A ROSELL C M BENEDITO C | 2004 | Food Hydrocolloids2004，18，24： | 1 |
| 12 | Erlotinib versuschemotherapy (CT) in advanced non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemo-therapy (EURTAC) phase III randomized trial 显示文摘 | Rosell R Gervais R Vergnenegre A | 2011 | J Clin Oncol2011，29，15： | 1 |
| 13 | Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease 显示文摘 | Rosell A Monso E Soler N | 2005 | Arch Intern Med2005，165，8： | 1 |
| 14 | A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke显示文摘 | Rosell A AlvarezSabin J Arenillas JF | 2005 | Stroke2005，36，： | 1 |
| 15 | Simultaneousdetermination of methyl tert-butyl ether, its degradation productsand other gasoline additives in soil samples by dosed-systempurge-and-trap gas chromatography-mass spectrometry 显示文摘 | Rosell M Lacorte S Ginebreda A | 2006 | Journal of Chromatography A2006，1132，12： | 1 |
| 16 | Effect of microbial transglutaminase on the rbeological and thermal properties of insect damaged wheat flour 显示文摘 | Caballero P A Bonet A Rosell C M Gomez M | 2005 | Journal of Cereal Science2005，42，1： | 1 |
| 17 | MetaUoproteinase and stroke infarct size: role for anti-inflammatory treatment? 显示文摘 | Moraneho A Rosell A Garela-Bonilla L | 2010 | Ann NY Aead Sei2010，1207，： | 1 |
| 18 | Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations:interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase Ⅲ randomized trial显示文摘 | Rosell R Gervais R Vergnenegre A | | 0，，： | 1 |
| 19 | Functionality of porous starch obtained by amylase or amyloglucosidase treatments显示文摘 | Dura A Baszczak W Rosell C M | 2014 | Carbohydrate Polymers2014，101，： | 1 |
| 20 | The treatment of advanced gastric cancer:current strategies and future perspectives显示文摘 | Cervantes A Rosell S Roda D | 2008 | Ann Oncol2008，，5： | 1 |
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