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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 3 | Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development显示文摘 | Colrn I Caro D Bourdony C J and Rosario O | 2000 | Environmental Health Perspectives2000，108，： | 1 |
| 4 | RAGE regulates the metabolic and inflammatory response to high-fat feeding in mice 显示文摘 | Song F Hurtado del Pozo C Rosario R | 2014 | Diabetes2014，63，6： | 1 |
| 5 | Alcohol and drug use and sexual behaviors placing runaways at risk for HIV infection显示文摘 | Koopman C Rosario M Rotheram - Borus MJ | 1994 | Addict Behav1994，19，： | 1 |
| 6 | NB2001, a novel antibacterial agent with broad-spectrum activity and enhanced potency against β - lactamase-producing strains 显示文摘 | Qing Li Jean YL Rosario C | 2002 | Antimicrob Agents Chemother2002，46，5： | 1 |
| 7 | In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic 显示文摘 | Kumar V Chapple C R Rosario D | 2010 | Eur Urol2010，57，6： | 1 |
| 8 | Using a Concordancer in Literary Studies显示文摘 | M Rosario C Rodriguez | 1999 | The European English Messenger1999，，： | 1 |
| 9 | Investigation of pseudocapacitive properties of RuOz film electrodes prepared by polymeric precursor method 显示文摘 | ROSARIO A V BULHOES L S PEREIRA E C | 2006 | Journal of Power Sources2006，158，： | 1 |
| 10 | A multidimensional model of obsessive - compulsive disorder 显示文摘 | MATAIX COLS D ROSARIO CAMPOS M C LECKMAN J F | 2005 | Am J Psychiatry2005，162，2： | 1 |
| 11 | Identification of phthalate esters in the serum of young Puerto Riean girls with premature breast development 显示文摘 | Colon I Care D Bourdony C J Rosario O | 2000 | Environ Health Perspect2000，108，9： | 1 |
| 12 | Speciation of metallothionein-like proteins of the mussel Mytilus edulis by orthogonaI separate on mechanisms with induetively coupled plasma-mass spectrometry detection: effect of sele nium Administration 显示文摘 | Ferrarello C N del Rosario Fernandez de la Campa M Carrasco J F | 2002 | Spectrochimica Acta Part B: Atomic Spectroscopy2002，57，3： | 1 |
| 13 | Alcohol and drug use and sexual brhaviors placing runaways at risk for HIV infection显示文摘 | Koopman C Rosario M Rotheram-Borus MJ | 1994 | Addict Behav1994，19，1： | 1 |
| 14 | Properties and functional significance of Saccharomyces cerevisiae ADHVI 显示文摘 | Larroy C Rosario Femandez M Gonzalez E | 2003 | Chem Biol Interact2003，，： | 1 |
| 15 | Service Offshoring and White - Collar Em- ployment 显示文摘 | Rosario C | 2010 | Review of Economic Studies2010，，2： | 1 |
| 16 | An International analysis ofthe quality of open government data portals显示文摘 | MARTIN A S ROSARIO A H D PéREZL M D C C | 2015 | Social science computer review2015，，6： | 1 |
| 17 | Roseman, David Wireless pH testing as an adjunct to unsedated transnasal esophagoscopy :The safety and efficacy of tran- snasal telemetry capsule placement 显示文摘 | Belafsky P Allen C Castro-Del Rosario | 2004 | Otolaryngology- Head and Neck Surgery2004，131，1： | 1 |
| 18 | Effect of the phytoestrogen genistein on hot flush,endometrium,and vaginal epithelium in postmenoupausal women:A 1-year randomized,double-blind,placebo-controlled study显示文摘 | Maria L C | 2007 | Menopause2007，14，4： | 1 |
| 19 | Surface modification of carbon black by oxidation and its influence on the activity of immobilized catalase and iron-phthalocyanines 显示文摘 | Rosario C S Rudy F P Patricia E N | 1996 | Journal of Molecular Catalysis A : Chemical1996，110，2： | 1 |
| 20 | Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene显示文摘 | JSUINO BS CASIMIRO C do ROSARIO VE | 2006 | Int J Med Sci2006，3，1： | 1 |
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