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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Pleiotropic effects of lactate dehydrogenase inactivationin Lactobacillus casei显示文摘 | María J José L G Vicente M Gaspar P | 2005 | Research in Microbiology2005，156，： | 1 |
| 3 | Bioactive norsesquiterpenes from Helianthus annuus with potential allelopathic activity显示文摘 | FRANCISO A M ROSA M V ASCENSI(O)N T | 1998 | Phytochemistry1998，48，4： | 1 |
| 4 | 查看详情显示文摘 | Skrobot F C Rosa L V M arques P A | | 0，，： | 1 |
| 5 | Efficient constitutive expression of Bacillus subtilis xylanase A in Eseherichia coil DH5alpha under the control of the Bacillus BsXA promoter显示文摘 | Kuller K Rosa J C Faca V M | 2006 | Biotechnol Appl Biochem2006，43，1： | 1 |
| 6 | A validated solid - liquid extraction method for the HPLC determination of polyphenols in apple tissues Comparison with pressurised liquid extraction显示文摘 | ROSA M ALEJANDRO B EDURNE C LUIS A BLANCA G FRANCISCA V | 2005 | Talanta2005，，65： | 1 |
| 7 | Gliotoxin naturalincidence and toxigenicity of Aspergillus fumigatus isolatedfrom corn silage and ready dairy cattle feed显示文摘 | Pereyra C M Alonso V A Rosa C A | 2008 | World Myco-toxin Journal2008，1，4： | 1 |
| 8 | Conversion to sirolimus: a successful treatment for post transplantation Kaposis sarcoma 显示文摘 | CAMPISTOL J M GUTIERREZ-DALMAU A TORREG- ROSA J V | 2004 | Transplantation2004，77，5： | 1 |
| 9 | Multi-objective evolutionary particle swarm optimization in the assessment of the impact of distributed generation 显示文摘 | MACIEL R S ROSA M MIRANDA V | 2012 | Electric Power Systems Research2012，89，： | 1 |
| 10 | Neurotoxic effects of trimethyhin and triethyltin on human fetal neuron and astrocyte cultures: A comparative study with rat neuronal cultures and human cell lines 显示文摘 | Rosa M Cristofol SG David V | 2004 | Toxicol Letter2004，152，1： | 1 |
| 11 | Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti -inflammatory pathway 显示文摘 | Pavlov V A Parrish WR Rosas - Ballina M | 2009 | Brain Behav Immun2009，23，1： | 1 |
| 12 | Recognition and autocompletion of partially drawn symbols by using polar histograms as spatial relation descriptors显示文摘 | Costagliola G de Rosa M Fuccella V | 2014 | Computers & Graphics2014，39，2： | 1 |
| 13 | Neridronate improves bone mineral density and reduces back pain in β-thalassaemia patients with osteoporosis:results from a phase 2,randomized,parallel-arm,open-label study显示文摘 | Forni GL Perrotta S Giusti A Quarta G Pitrolo L Cappellini MD D'Ascola DG Borgna Pignatti C Rigano P Filosa A Iolascon G Nobili B Baldini M Rosa A Pinto V Palummeri E | | 0，，： | 1 |
| 14 | Stable, inducible thermoacidophilic alpha-amylase from Bacillus acidocaldarius 显示文摘 | BUONOCORE V CAPORALE C DE ROSA M | 1976 | J Baeteriol1976，128，2： | 1 |
| 15 | Rapid estimation of the manufacturing cost of extracts obtained by supercritieal fluid extraction 显示文摘 | Paulo T V Rosa Meireles M A A | 2005 | Journal of Food Engineer- ing2005，67，12： | 1 |
| 16 | Highpower performance of single mode fiber-opticconnectors显示文摘 | Rosa M D Carberry J Bhagavatula V etal | 2002 | Journal of Lightwave Technology2002，20，5： | 1 |
| 17 | New materials for water electrolysis diaphragms显示文摘 | Rosa V M Santos M B F Silva E P DA | 1995 | International Journal of Hydrogen Energy1995，20，9： | 1 |
| 18 | Intracellular metabolic pathways control immune tolerance 显示文摘 | PROCACCINI C GALGANI M DE ROSA V | 2012 | Trends Immu-nol2012，33，1： | 1 |
| 19 | Recognition and autocompletion of partially drawn symbols by using polar histograms as spatial relation descriptors显示文摘 | COSTAGLIOLA G DE ROSA M FUCCELLA V | 2014 | Computers & Graphics2014，39，4： | 1 |
| 20 | Phytic acid content in milled cereal products and breads显示文摘 | ROSA M G E EDUARDO G H BELEAN G V | 1999 | Food Research International1999，32，： | 1 |
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