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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | 采用不同导管和技术的去肾交感神经术治疗单纯收缩期高血压:一项随机试验结果显示文摘目前认为单纯收缩期高血压(isolated systolic hypertension,ISH)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RDN方法的RADIOSOUND-HTN(采用不同RDN导管与技术治疗顽固性高血压患者的三臂随机试验)数据,探讨ISH与RDN反应的可能交互作用。 | Fengler K Rommel KP Lapusca R Blazek S Besler C Hartung P von Roeder M Kresoja KP Desch S Thiele H Lurz P 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，7： | 2 |
| 4 | Collector efficiency factor F'for absorbers with rectangular fluid ducts contacting the entire surface显示文摘 | Rommel M Moock W | 1997 | Solar Energy1997，60，34： | 2 |
| 5 | PI3K5 and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?显示文摘 | ROMMEL C CAMPS M JI H | 2007 | Nat Rev Immunot2007，7，3： | 1 |
| 6 | Hemostatic alterations in pigs fed sublethal doses of Sarcocystis miescheriana 显示文摘 | Daugschies A A Itfeld E Rommel M | 1989 | Vet Parasitol1989，34，12： | 1 |
| 7 | PI3K+ and PI3K+/: partners in crime in inflammation in rheumatoid arthritis and beyond 显示文摘 | Rommel C Camps M Ji H | 2007 | Nat Rev Immunol2007，7，3： | 1 |
| 8 | Early diagnosis inpost-traumatic complex regional pain syndrome显示文摘 | Schurmann M Gradl G Rommel O | 2007 | Or-thopedics2007，30，6： | 1 |
| 9 | Comparative efficacy of anti-coccidials under the conditions of commercial broiler production and in battery trials显示文摘 | Daugschiesa Gabsslein U Rommel M | 1998 | Vet Parasitol1998，76，： | 1 |
| 10 | Studies of resistance to anticoccidials in Eimeria field isolates and pure Eimeria strains显示文摘 | Stephan B Rommel M Daugschiesa | 1997 | Parasitology1997，69，： | 1 |
| 11 | Accuracy of wafer level alignment with substrate conformal imprint lithography 显示文摘 | Fader R Rommel M Bauer A | 2013 | Journal of Vacuum Science & Technology B2013，31，6： | 1 |
| 12 | Targeting dual-specificity phosphatases:manipulating MAP kinase signalling and immune responses显示文摘 | Jeffrey KL Camps M Rommel C | 2007 | Nat Rev Drug Discov2007，6，5： | 1 |
| 13 | Efficient single glazed flat plate photovoltaic-thermal hybrid collector for domestic hot water system显示文摘 | Dupeyrat P Rommel M Henning H M | 2011 | Solar Energy2011，85，7： | 1 |
| 14 | PET study of Changes in l ocal brain hemodynamics and oxygen metabolism after unilateral middle cerebral a rtery occlusion in baboons显示文摘 | Fiorelli M Rommel T | 1993 | J Cereb Blood Flow Metab1993，13，： | 1 |
| 15 | Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials 显示文摘 | DAUGSCHIES A GASSLEIN U ROMMEL M | 1998 | Vet Parasitol1998，76，3： | 1 |
| 16 | Performance evaluation of the 'large SMADES' autonomous desalination solar-driven membrane distillation plant in Aqaba, Jordan 显示文摘 | Banat F Jwaied N Rommel M | 2007 | Desalination2007，217，13： | 1 |
| 17 | Studies of resistance to anticoceidials in Eimeria field isolates and pure Eimeria strains显示文摘 | Stephan B Rommel M Daugschies A | 1997 | Vet Parasitol1997，69，： | 1 |
| 18 | Prospects for integrated storage collector systems in central Europe显示文摘 | A Goetzherger and M Rommel | 1987 | Solar Energy1987，39，3： | 1 |
| 19 | PET Study of Changes in Local Brain Hemodynamies and Oxygen Metabolism after Unilateral Middle Cerebral Artery Occlusion in Baboons显示文摘 | Pappata S Fiorelli M Rommel T | 1993 | J Cereb Blood Flow Metab1993，13，3： | 1 |
| 20 | Paucisymptomatic brainstem lesions revealing CNS schistosomiasis显示文摘 | Rage M Duprez T | 2005 | Acta Neurol Belg2005，105，： | 1 |
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