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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Evaluation and treatment of internal impingement of the shoulder in overhead athletes显示文摘One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulderpain resulting from internal impingement. 'Internal impingement' is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial,involving physiologic shoulder remodeling,posterior capsular contracture,and scapular dyskinesis. Throwers with internal impingement may complain of shoulder stiffness or the need for a prolonged warm-up,decline in performance,or posterior shoulder pain. On physical examination,patients will demonstrate limited internal rotation and posterior shoulder pain with a posterior impingement test. Common imaging findings include the classic 'Bennett lesion' on radiographs,as well as articular-sided partial rotator cuff tears and concomitant SLAP lesions. Mainstays of treatment include intense non-operative management focusing on rest and stretching protocols focusing on the posterior capsule. Operative management is variable depending on the exact pathology,but largely consists of rotator cuff debridement. Outcomes of operative treatment have been mixed,therefore intense non-operative treatment should remain the focus of treatment. | Keith T Corpus Christopher L Camp David M Dines David W Altchek Joshua S Dines | 2016 | World Journal of Orthopedics2016，7，12： | 2 |
| 4 | PI3K5 and PI3Kγ: partners in crime in inflammation in rheumatoid arthritis and beyond?显示文摘 | ROMMEL C CAMPS M JI H | 2007 | Nat Rev Immunot2007，7，3： | 1 |
| 5 | Cisplatin plus gemcitabine versus a cisplatin based triplet versus nonplatinum sequential doublets in advanced non-small cell lung cancer: a Spanish Lung Cancer Group phase Ⅲ randomized trial显示文摘 | ALBEROLA V CAMPS C PROVENC IO M | 2003 | J Clin Oncol2003，21，17： | 1 |
| 6 | Improving drought tolerance in maize: a view from industry显示文摘 | Campes H Cooper M Habben J E | 2004 | Field Crop Research2004，90，： | 1 |
| 7 | Wideband radar for ballistic missile defense and range-Doppler imaging of satellites 显示文摘 | Camp W W Mayhan J T O' Donnell R M | 2000 | The Lincoln Laboratory Journal2000，12，2： | 1 |
| 8 | Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regula-ted manner显示文摘 | Abella A Garcia-Vicente S Viguerie N Ros-Baro A Camps M Palacin M | 2004 | Diabetologia2004，47，3： | 1 |
| 9 | The effect of temperature and humidity on electrospinning显示文摘 | S. Vrieze T. Camp A. Nelvig B. Hagstr?m P. Westbroek K. Clerck | 2009 | Journal of Materials Science2009，，5： | 1 |
| 10 | PI3K+ and PI3K+/: partners in crime in inflammation in rheumatoid arthritis and beyond 显示文摘 | Rommel C Camps M Ji H | 2007 | Nat Rev Immunol2007，7，3： | 1 |
| 11 | L- band sea surface emissivity: Preliminary results of the WISE- 2000 campaign and its application to salinity retrieval in the SMOS mission显示文摘 | CAMPS A CORBELLA I VALL-LLOSSERA M | 2003 | Radio Science2003，38，4： | 1 |
| 12 | Strategic Entrepreneurship: Entrepreneurial Strategies for Wealth Creation 显示文摘 | HITT M A IRELAND R D CAMP S M | 2001 | Strategic Management Journal2001，22，6： | 1 |
| 13 | ()zone, sulfur dioxide, and ultraviolet have similar effects on mRNA ac cumulation of antioxidant genes in Nicotiana plumbagimfolia L显示文摘 | Willekens H Van Camp W Van Montagu M | 1994 | Plant Physiology1994，，106： | 1 |
| 14 | X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization 显示文摘 | Camp RL Dolled-Filhart M Rimm DL | 2004 | Clinical cancer research : an official journal of the American Association for Cancer Research2004，10，21： | 1 |
| 15 | Subsurface damage and polishing compound affect the 355 nm laser damage threshold of fusedsilica surfaces显示文摘 | Camp D W Kozlowski M R Sheehan L M | 1998 | Proceedings of SPIE1998，3244，： | 1 |
| 16 | Strategic entrepreneurship : entrepreneurial strategies for wealth creation 显示文摘 | HITI' M A IRELAND R D CAMP S M | 2001 | Strategic management journal2001，22，67： | 1 |
| 17 | Regulation of sulfate assimilation by nitrogen in Arabidopsis显示文摘 | Koprivova A Suter M Camp R O | 2000 | Plant Physiol2000，122，： | 1 |
| 18 | Temperatures after bloom affect plant growth and fruit quality of strawberry 显示文摘 | Wang S Y Camp M J | 2000 | Scientia Horticulturae2000，85，： | 1 |
| 19 | A new autosomal recessive form of Stickler syndrome is caused by a mutation in the COL9A1 gene 显示文摘 | Van Camp G Snoeckx RL Hilgert N van den Ende J Fukuoka H Wagatsuma M | 2006 | Am J Hum Genet2006，79，3： | 1 |
| 20 | Necrotizing enterocolitis in 20, 822 infants: analysis of medical and surgical treatments 显示文摘 | Abdullah F Zhang Y Camp M | 2010 | Clin Pediatr2010，49，2： | 1 |
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