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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | 卵巢子宫内膜样癌的分子学异质性:对166例采用子宫内膜癌的分子分类分析显示文摘在临床和生物学上,卵巢子宫内膜样癌(EOC)是不同于其他组织学类型的卵巢癌,但在形态学和分子生物学特征上与子宫内膜样癌有相似之处。根据新的子宫内膜癌分子分类分析EOC的分子学异质性,并评价该分子分类的预后意义。作者对166例早期EOC行免疫组化分析错配修复蛋白和p53的表达,并用Sanger测序法检测聚合酶epsilon的核酸外切酶结构域(POLL EDM)。另外,通过二代测序分析POLE EDM的突变,以确认超突变情况。8例肿瘤示POLE EDM突变,属超突变(5%);29例肿瘤示错配修复缺陷,属高突变(18%);16例肿瘤示p53表达突变,属p53异常(11%);114个肿瘤无上述改变,属非特异类型(66%)。5例肿瘤示>1个分类标准。 | Leskela S Romero I Rosa-Rosa J M 赵芳(译) 魏建国(审校) | 2021 | 临床与实验病理学杂志2021，37，4： | 3 |
| 3 | Natural products:Perspectives in the pharmacological treatment of gastrointestinal anisakiasis显示文摘Objective: To evaluate the activity of different natural products against L3 larvae of Anisakis type I. Methods: Information on investigations into the activity of natural products against the L3 larvae of Anisakis simplex was collected from scientific journals, books, theses and reports via a library and electronic search(using Pubmed, Scopus, Medline, Web of Science and Science Direct). The search terms included: natural products, medicinal plants, essential oils, terpenic derivatives, Anisakis, antinematodal activity. Results: In the literature reviewed numerous papers were found concerning the in vitro and in vivo activity against Anisakis type I of various natural products(plant extracts, essential oils and their major components). Analysis of the results showed that in vitro tests the Melaleuca alternifolia essential oil and the ar-turmerone isolated from Curcuma longa displayed the greatest activity. In vivo, the most active compound was perillaldehyde, the main component of Perilla frutescens essential oil. Conclusions: This study shows that some natural products exhibited promising antianisakis properties. | Valero A Romero MC Gómez-Mateos M Hierro I Navarro MC | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 2 |
| 4 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 5 | Textural and structural modifications of saponite from Cerro del Aguila by acid treatment 显示文摘 | BARRIOS M S BUEY C S ROMERO E G | 2001 | Clay Miner2001，36，： | 2 |
| 6 | Lipid peroxidation products and antioxidants in human disease显示文摘 | Romero F J Morell F B Romero M J | 1998 | Environ Health Perspect1998，106，： | 1 |
| 7 | Getting the interactions right: Will higher O3 levels interfere with induced defenses to aphid feeding? 显示文摘 | Menendez A I Romero A M Folcia A M | 2008 | Basic and Applied Ecology2008，10，3： | 1 |
| 8 | How do glucocorticoids influence stress responses? Integrating permissive,suppressive,stimulatory,and preparative actions显示文摘 | SAPOLSKY R M ROMERO L M MUNCK A U | 2000 | Endocr Rev2000，21，1： | 1 |
| 9 | Tensile Testing of EP-823 and HT-9 After Irradiation in STIP Ⅱ 显示文摘 | Maloy Stuart A Romero T James M R | 2006 | Journal of Nuclear Materials2006，356，123： | 1 |
| 10 | Expression of the yeast trehalose-6-phosphate synthase gene in transgenic tobacco plants :pleiotropic phenotypes include drought tolerance 显示文摘 | CARLOS ROMERO JOSE M BELLES JOSE L | 1997 | Planta1997，201，： | 1 |
| 11 | Interception of the electron transport chain in bacteria with hydrophilic redox mediators显示文摘 | Lithgow A M Romero L Sanchez I C | 1986 | J Chem Res Synop1986，，5： | 1 |
| 12 | Floricaula:a homeotic gene required for flower development in Antirrhinum majus显示文摘 | Coen E S Romero J M Doyle S | 1990 | Cell1990，63，： | 1 |
| 13 | Indications for percutaneous nephrostomy in patients with obstructive Urupathy duo to malignant urogenital neoplasias 显示文摘 | Romero F R Broglio M Pires S R | 2005 | Int Braz J Urol2005，31，2： | 1 |
| 14 | M(o)ssbauer effect and X-ray distribution function analysis in complex Na2O-CaO-ZnO-Fe2O3-Al2O3-SiO2 glass and glass-ceramics显示文摘 | ROMERO M RINC(O)N J M M(U)SIL S | 1999 | Mater Res Bull1999，34，7： | 1 |
| 15 | Previous prescrip- tion of beta - blockers is associated with reduced mortality among patients hospitalized in intensive care units for sepsis 显示文摘 | Macchia A Romero M Comiguani PD | 2012 | Crit Care Med2012，40，10： | 1 |
| 16 | Quantification of chlorpheniraminemaleate enantiomers by ultraviolet spectroscopy and chemometricmethods 显示文摘 | VALDERRAMA P ROMERO A L IMAMURA P M | 2010 | Analytical and Bioanalytical Chemistry2010，397，1： | 1 |
| 17 | Determination of organic acids in grape musts, wines and vinegars by high performance liquid-chromatography显示文摘 | ROMERO E G MUNOZ G S ALVAREZ P J M | 1993 | Journal of Chromatography A1993，655，1： | 1 |
| 18 | Resveratrol regulates cellular PKC α and δto inhibit growth and induce apoptosis in gastric cancer cells 显示文摘 | Atten M J Godoy - Romero E Attar BM | 2005 | Investigational New Drugs2005，23，： | 1 |
| 19 | Temperature conversion (mesophilic to thermophilic) of municipal sludge digestion 显示文摘 | De la Rubia M A Romero L I Sales D | 2005 | Aiche Journal2005，51，9： | 1 |
| 20 | Transmission network expansion planning considering uncertainty in demand显示文摘 | Silva I J Rider M J Romero R | 2006 | IEEE Transactions on Power Systems2006，21，4： | 1 |
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