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| 1 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 2 | Adaptive Control for Passive Kinesiotherapy ELLTIO显示文摘 | Ricardo López Hipólito Aguilar Sergio Salazar Rogelio Lozano | 2014 | Journal of Bionic Engineering2014，11，4： | 4 |
| 3 | Energy control of the pendubot 显示文摘 | ISABAELLE F ROGELIO L MARK W S | 2000 | IEEE Trans on Automatic Control2000，45，4： | 1 |
| 4 | An observer-based compensator for distribu- ted delays 显示文摘 | ROGELIO L ASOK R | 1990 | Automatica1990，6，5： | 1 |
| 5 | On the passivity of linear delay sys- tems 显示文摘 | Silviu-Inlian N ROGELIO L | 2001 | IEEE Transactions on Automatic Control2001，46，3： | 1 |
| 6 | Adaptive control for a radio-controlled helicopter in a vertical flying stand 显示文摘 | Alejandro D Rogelio L Pedro C | 2004 | International Journal of Adaptive Control and Signal Processing2004，18，5： | 1 |
| 7 | Modeling and vibration mode analysis of a ball screw drive显示文摘 | Vicente Diego A Hecker Rogelio L Villegas Fernando J | 2012 | International Journal of Advanced Manufacturing Technology2012，58，14： | 1 |
| 8 | Predictive modeling of surface roughness in grinding显示文摘 | Rogelio L H St even Y L | 2003 | International Journal of Machine Tools&Manufacture2003，，43： | 1 |
| 9 | Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage显示文摘 | YOLANDA S ROGELIO L JAVIER T | 2005 | Stroke2005，36，1： | 1 |
| 10 | Explicit Approximations for All Eigenvalues of the I-D Transient Heat Conduction Equations显示文摘 | James W S Rogelio L | 1999 | Heat Transfer Engineering1999，20，2： | 1 |
| 11 | Explicit Solutions for Transcendental Equations显示文摘 | James W S Rogelio L | 2002 | Society for Industrial and Applied Mathematics2002，44，2： | 1 |
| 12 | Real-time stabilization of an eight- rotor UAV using optical flow 显示文摘 | Hugo R Sergio S Rogelio L | 2009 | IEEE Transactions on Robot- ics2009，25，4： | 1 |
| 13 | Machining process monitoring and control:The state-of-the-art显示文摘 | Liang Steven Y Hecker Rogelio L Landers Robert G | 2004 | Journal of Manufacturing Science and Engineering2004，126，5： | 1 |
| 14 | An observe-based compensat for distributed delays显示文摘 | Rogelio L Ray A | 1999 | Automatica1999，，5： | 1 |
| 15 | An observe-based compensator for distributed delays显示文摘 | ROGELIO L RAY A | 1990 | Automatica1990，26，25： | 1 |
| 16 | Predictive Modeling of Surface Roughness in Grinding显示文摘 | Rogelio L H Steven Y L | 2003 | International Journal of Machine Tools&Manufacture2003，43，： | 1 |
| 17 | The conformation of aldisin and analogues, a potential model for expanded nucleosides 显示文摘 | SHAMIL L ROGELIO F EMILIO Q | 1995 | Tetrahedron1995，51，4： | 1 |
| 18 | Predictivemodeling of surface roughness in grinding显示文摘 | Hecker Rogelio L Liang Steven Y | 2003 | International Journal of Machine Tools and Manufacture2003，43，8： | 1 |
| 19 | Assessment of sources and fate of nitrate in shallow groundwater of an agricultural area by using a multi-tracer approach显示文摘 | ERNESTO P Z ROGELIO L R THOMAS H | 2014 | Science of the Total Environment2014，，： | 1 |
| 20 | Synthesis,characterization and antibacterial activity of copper,nickel and bimetallic Cu–Ni nanoparticles for potential use in dental materials显示文摘The antibacterial effect is a desirable property in dental materials.Development of simple methods for the preparation of nanosized metal particles has attracted significant attention because of their future applications due to unusual size-dependent antibacterial properties.Copper(Cu),Nickel(Ni) and bimetallic Cu–Ni nanoparticles were prepared by a simple chemical method and their antibacterial activity was tested against the widely used standard human pathogens Staphylococcus aureus(gram-negative) and Escherichia coli(gram-positive).Additionally,these nanoparticles were tested against the dental pathogen Streptococcus mutans.Our results are promising for potential use in dental materials science. | Liliana Argueta-Figueroa Raúl A.Morales-Luckie Rogelio J.Scougall-Vilchis Oscar F.Olea-Mejía | 2014 | Progress in Natural Science:Materials International2014，24，4： | 1 |
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