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| 1 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 2 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 3 | Preservation of platelet function in patients with cirrhosis and thrombocytopenia undergoing esophageal variceal ligation显示文摘Background:Thrombocytopenia is a possible risk factor for bleeding after band ligation of esophageal varices.However,elevated von Willebrand factor(VWF)in cirrhosis improves platelet function and could decrease this risk.Our objective was to assess platelet function in patients with cirrhosis undergoing esophageal variceal ligation(EVL).Methods:The assessment consisted of platelet count,antigen and activity of VWF and VWF-cleaving protease ADAMTS-13 activity,and a platelet adhesion and aggregation test simulating vascular flow in vivo(Impact-RR)prior to EVL.Results:Totally 111 patients were divided into three groups according to platelet count:(1)<50×109/L(n=38,34.2%);(2)50×109/L to 100×109/L(n=47,42.3%);and(3)>100×109/L(n=26,23.4%).No statistically significant difference was found in the aggregate size of platelets[group 1:41.0(31.8–67.3)μm 2;group 2:47.0(33.8–71.3)μm 2;and group 3:47.0(34.0–66.0)μm 2;P=0.60]and no significant correlation was found between aggregate size and platelet count(Spearman r=0.07;P=0.47).Surface coverage was 4.1%(2.8%–6.7%),8.5%(4.0%–10.0%),and 9.0%(7.1%–12.0%)(P<0.001)in groups 1,2 and 3,respectively and correlated with platelet count(Spearman r=0.39;P<0.0001).There was no significant difference between groups in VWF or ADAMTS-13.Post-EVL bleeding occurred in six(5.4%)patients(n=2 in group 1,n=1 in group 2,and n=3 in group 3;P=0.32).Patients with bleeding had higher MELD scores[15.0(11.3–20.3)versus 12.0(10.0–15.0);P=0.025],but no difference was demonstrated for platelet function parameters.Conclusion:Platelet function is preserved even in the presence of thrombocytopenia,including in the patients with post-EVL bleeding. | Evandro de Oliveira Souza Elbio Antonio D’Amico Tania Rubia Flores da Rocha Caroline Marcondes Ferreira Juliana Medeiros Batista Luiz Augusto CarneiroD’Albuquerque Flair Jose Carrilho Alberto Queiroz Farias | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，6： | 3 |
| 4 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 5 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | Mesa-Perez J M Cortez L A B Rocha J D | 2005 | Fuel Processing Technology2005，86，5： | 1 |
| 6 | Analysis of public single nudeotide polymorphisms in commercial pig populations显示文摘 | KOLLERS S MEGY K ROCHA D | 2005 | Animal Genetics2005，36，： | 1 |
| 7 | Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study显示文摘 | Kurreeman F A S Rocha D Houwing-Duistermaat J | 2008 | Arthritis &Rheumatism2008，58，9： | 1 |
| 8 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | L A B Cortez J D Rocha | 2005 | Fuel Processing Technology2005，86，： | 1 |
| 9 | Psychosocial risk factors in coronary heart disease:beyond type A behavior显示文摘 | Trigo M Silva D Rocha E | 2005 | Rev Port Cardiol2005，24，2： | 1 |
| 10 | A comparison of proper orthngonal decomposition and Mote Carlo simulation of wind pressure data显示文摘 | Rocha M M Cabral S V S Riera J D | 2000 | Journal of Wind Engineering Industrial Aerodynamics2000，84，： | 1 |
| 11 | A phase Ⅱ trial of perifosine in locally advanced, unresectable, or metastatic pancreatic adenocarcinoma 显示文摘 | Marsh Rde W Rocha Lima C M Levy D E | 2007 | Am J Clin Oncol2007，30，1： | 1 |
| 12 | Brazilian Bromeliaceae species:isolation of arylpropanoid acid derivatives and antiradical potential显示文摘 | Rocha F D Yano M Cunha M R | 2010 | Rev Bras Farmacogn2010，20，2： | 1 |
| 13 | Hydrothermal origin of soft hematite ore in the Quadrildtero Ferrifero of Minas Gerais,BrazilPetrographic evidence from the Gongo Soco iron ore deposit显示文摘 | Cabral A R Rocha Filho 0 G Jones R D | 2003 | Applied Earth Science: Trans Inst Min Metall B2003，112，： | 1 |
| 14 | Use of rice straw as biosorbent for removal of Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and Hg(Ⅱ)ion in industrial effluent显示文摘 | ROCHA C G ZZIA D A ALFAYA R V | 2009 | Journal of Hazardous Material2009，166，： | 1 |
| 15 | Modifications of 5-HT4 receptor expression in rat brain during memory consolidation 显示文摘 | Manuel-Aplinar L Rocha L Pascoe D | 2005 | Brain Res2005，1042，1： | 1 |
| 16 | Effects of Non-nutritive Sucking and Oral Stimulation on Breastfeed- ing Rates for Preterm,Low Birth Weight Infants: a Random- ized Clinical Trial显示文摘 | Pimenta H P Moreira M E Rocha A D | 2008 | J Pediatr (Rio J)2008，84，5： | 1 |
| 17 | Enantioselective ethylation of aldehydes with 1,3-N-donor ligands derived from (+)-camphoric acid显示文摘 | MURTINHO D ELISA S S M ROCHA G | | 0，，： | 1 |
| 18 | Use of rice straw as biosorbent for removal of Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ) and Hg(Ⅱ)ion in industrial effluents显示文摘 | ROCHA C G ZAIA D A M ALFAYA R V D S | | 0，，： | 1 |
| 19 | A comparison of proper orthogonal decomposition and Monte Carlo simulation of wind pressure显示文摘 | M M Rocha S VS Cabral J D Riera | 2000 | Wind Englnd Aerodyn2000，84，： | 1 |
| 20 | Regulation of NF- kappaB and p53 through activation of ATR and Chkl by the ARF tumour suppressor 显示文摘 | Rocha S Garrett M D Campbell K J | 2005 | EMBO J2005，24，6： | 1 |
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