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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | The action of seven convulsants as antagonists of the GABA response of Limulus neurons 显示文摘 | Roberts CJ James VA Collins JF | 1981 | Comp Biochem Physiol C1981，70，： | 1 |
| 3 | The action of seven convulsants as antagonists of the GABA response of limulus neurons 显示文摘 | Roberts CJ James VA CoUins | 1981 | Compar- ative Biochemistry and Physiology1981，，70： | 1 |
| 4 | Myelodysplastic syndromes with deletions of chromosome 11q lack cryptic MLL rearrangement and exhibit characteristic clinicopathologic features显示文摘 | Sa AW Lynne VA Robert PH | 2011 | Leukemia Research2011，35，3： | 1 |
| 5 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 6 | Surveillance for wa- terborne disease outbreaks and other health events associated with recreational water - United States, 2007-2008显示文摘 | Hlavsa MC Roberts VA Anderson AR | 2011 | MMWR Surveill Summ2011，60，12： | 1 |
| 7 | Acute gastroenteritis surveillance through the National Outbreak Reporting System, United States 显示文摘 | Hall AJ Wikswo ME Manikonda K Roberts VA Yoder JS Gould LH | 2013 | Emerg Infect Dis2013，19，8： | 1 |
| 8 | Repair of the dura materwith processed collagen devices 显示文摘 | Zerris VA James KS Roberts JB | 2007 | J Biomed Mater Res B ApplBiomater2007，83，2： | 1 |
| 9 | The action of seven consultants as antagonists of the GABA response of Limulus neurons 显示文摘 | Roberts C J James VA Collins JF | 1981 | Comp Biochem Physiol C1981，70，1： | 1 |
| 10 | Suspension Plasma Spraying: Process Characteristics and Applications显示文摘 | Robert Va?en Holger Ka?ner Georg Mauer Detlev St?ver | 2010 | Journal of Thermal Spray Technology (-)2010，，1： | 1 |
| 11 | Failure mechanisms of magnesia alumina spinel abradable coatings under thermal cyclic loading显示文摘 | Svenja Ebert Robert Mücke Daniel Mack Robert Va?en Detlev St?ver Tanja Wobst Susanne Gebhard | 2013 | Journal of the European Ceramic Society2013，，： | 1 |
| 12 | The antiemetic effectiveness of droperidol during morphine patient controlled analgesia显示文摘 | Roberts CJ Millar JM Goat VA | 1995 | Anaesthesia1995，50，6： | 1 |
| 13 | Testing and evaluation of thermal-barrier coatings显示文摘 | Robert Va?en Yutaka Kagawa Ramesh Subramanian Paul Zombo Dongming Zhu | 2012 | MRS Bulletin2012，，10： | 1 |
| 14 | Cryptosporidium species and subtypes and clinical manifestations in children,Peru显示文摘 | Cama VA Bern C Roberts J | 2008 | Emerg Infect Dis2008，14，10： | 1 |
| 15 | A high-performance aerosol concentrator for biological agent detection 显示文摘 | Romay FJ Roberts DL Marple VA | 2002 | Aerosol Science And Technology2002，36，： | 1 |
| 16 | Cryptosporidium species and subtypes and clinical manifestations in children,Peru显示文摘 | Cama VA Bern C Roberts J | 2008 | Emerg Infect Dis2008，14，10： | 1 |
| 17 | Planned,motivatedand habitual hygiene behaviour;An eleven country review显示文摘 | VALERIE AC LISA OD ROBERT VA | 2009 | HealthEdu Res2009，24，4： | 1 |
| 18 | A missense mutation in a highly conserved alternate exon of dynamin- 1 causes epilepsy in fitful mice显示文摘 | Boumil RM Letts VA Roberts MC | 2010 | PLoS Genet2010，6，10： | 1 |
| 19 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 20 | The antiemetic effectiveness of droperidol during morphine patient - controlled analgesia显示文摘 | Roberts CJ Millar JM Goat VA | 1995 | Anaesthesia1995，50，6： | 1 |
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