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67篇 您的检索式:作者名="ROBERT HENDERSON"
    题名 作者 年代 出处 被引量
1Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics.Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson 2015World Journal of Gastroenterology2015,21,1:7
2Impact of Premorbid Undernutrition on Outcome in Stroke Patients显示文摘James P. Davis Andrew A. Wong Philip J. Schluter Robert D. Henderson John D. O’Sullivan Stephen J. Read 2004Stroke: Journal of the American Heart Association2004,,8:2
3Angiographically Defined Collateral Circulation and Risk of Stroke in Patients With Severe Carotid Artery Stenosis显示文摘Robert D. Henderson Michael Eliasziw Allan J. Fox Peter M. Rothwell Henry J. M. Barnett 2000Stroke: Journal of the American Heart Association2000,,1:2
4RolEnact : role-based enact able models of businesss processes 显示文摘Keith Thomas Phalp Peter Henderson Robert John Waiters 1998Information and Software Technology1998,40,:1
5Gasification behaviour of Australian coals at high temperature and pressure 显示文摘Harris D J Roberts D G Henderson D G 2006Fuel2006,85,2:1
6LMX differentiation: A multilevel review and examination of its antecedents and outcomes显示文摘David J. Henderson Robert C. Liden Brian C. Glibkowski Anjali Chaudhry 2009The Leadership Quarterly2009,,4:1
7Ion and solvent transfer discrimination at a nickel hydroxide film exposed to LiOH by combined electrochemical quartz crystal microbalance (EQCM) and probe beam deflection (PBD) techniques显示文摘Heidi M French Mark J Henderson A Robert Hillman 0,,1:1
8Gasification behaviour of Australian coals at high temperature and pressure 显示文摘Harris D J Roberts D G Henderson D G 2006Fuel2006,85,2:1
9Gasification behaviour of australian coal at high temperature and pressure 显示文摘HARRIS D J ROBERTS D G HENDERSON D G 2006Fnel2006,85,2:1
10Gasification behaviour of australian coals at high temperature and pressure 显示文摘Harris D J Roberts D G Henderson D G 2006Fuel2006,85,2:1
11RolEnact:role based enact able models of businesss processes显示文摘Keith Thomas Phalp Peter Henderson Robert John Walters 1998Information and Software Technology1998,40,6:1
12Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes显示文摘Jerome L. Fleg Mihriye Mete Barbara V. Howard Jason G. Umans Mary J. Roman Robert E. Ratner Angela Silverman James M. Galloway Jeffrey A. Henderson Matthew R. Weir Charlton Wilson Mario Stylianou Wm. James Howard 2008Journal of the American College of Cardiology2008,,25:1
13Gasification behaviour of Australian coals at high temperature and pressure显示文摘Harris D J Roberts D G Henderson D G 2006Fuel2006,85,2:1
14Atomic forcemicroscopy reveals the stoichiometryand subunit arrangement of 5-HT3 re-ceptors 显示文摘NelsonP Barrera Paul Herbert Robert M Henderson et ai 2005PNAS2005,30,12:1
15Extended dynamic range from a combined linear - logarithmic CMOS image sensor 显示文摘Graeme Strom Robert Henderson 2006IEEE Journal of Solid State Circuits2006,41,9:1
16Mental accounting and categorization显示文摘Henderson P Robert A 1992Organizational Behavior& Human Decision Processes1992,51,1:1
17Gasification behaviour of Australian coals at high temperature and pressure 显示文摘Harris D J Roberts D G Henderson D G 2006Fuel2006,85,:1
18Molecular cloning and characterization of the rat P2Y4 receptor显示文摘Webb TE Henderson D Roberts JA 1998Neurchem1998,71,:1
19Risk factors for meningiomas in men in Los Angeles County显示文摘 Yu MC Henderson BE Roberts C 1983J Natl Cancer Inst1983,70,:1
20RolEnact: Role-based enaetable models of business process 显示文摘Keith Thomas Phalp Peter Henderson Robert John Walters et al 1998Information and Software Technology1998,40,3:1
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