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| 1 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 2 | Effects of intravenous glucose load on insulin secretion in patients with ketosis-prone diabetes during near-normoglycemia remission显示文摘 | Gosmanov AR Smiley D Robalino G | 2010 | Diabetes Care2010，33，4： | 1 |
| 3 | Intravenous intralipid induced blood pressure elevation and endothelial dysfunction in obese african americans with type 2 diabetes显示文摘 | Umpierrez GE Smiley D Robalino G | 2009 | J Clin Endocrinol Metab2009，94，2： | 1 |
| 4 | Double-stranded RNA induces sequence-specific antiviral silencing in addition to nonspecific immunity in a marine shrimp: convergence of RNA interference and innate immunity in the invertebrate antiviral response?显示文摘 | Robalino J Bartlett T Shepard E | 2005 | Joumal of virology2005，79，13： | 1 |
| 5 | Double-stranded RNA induces sequence-specific antiviral silencing in addition to nonspecific immunity in a marine shrimp: convergence of RNA interference and innate immunity in the invertebrate antiviral response显示文摘 | Robalino J Bartlett T Shepard E | 2005 | Journal of virology2005，79，13： | 1 |
| 6 | Lack of lipotoxicity effect onβ-cell dysfunction in ketosis-prone Type 2 diabetes显示文摘 | Umpierrez GE Smiley D Robalino G | 2010 | Diabetes Care2010，33，3： | 1 |
| 7 | Double-stranded RNA induces sequence-specific antiviral silencing in addition to nonspecific immunity in a marine shrimp:convergence of RNA interference and innate immunity in the invertebrate antiviral response显示文摘 | Robalino J Bartlett T Shepard E | 2005 | Journal of Virology2005，79，13： | 1 |
| 8 | Two zebrafish eIF4E family members are differentially expressed and functionally divergent显示文摘 | Robalino J Joshi B Fahrenkrug S C | 2004 | J Biol Chem2004，279，10： | 1 |
| 9 | Intravenous intralipid-induced blood pressure elevation and endothelial dysfunction in obese African-Americans with type 2 diabetes显示文摘 | UMPIERREZ GE SMILEY D ROBALINO | | 0，，02： | 1 |
| 10 | Respective prevalence of the dif-ferent carpentier classes of mitral regurgitation : a stepping stone for future thera-peutic research and development显示文摘 | de Marchena E Badiye A Robalino G | 2011 | J Card Surg2011，26，4： | 1 |
| 11 | Induction of antivlral im- munity by doublestranded RNA in a marine invertebrate显示文摘 | Robalino J Browdy C L Prior S | 2004 | J Virol2004，78，10： | 1 |
| 12 | Two zebrafish eIF4E family members are differentially expressed and functionally divergent显示文摘 | JOSHI B FAHRENKRUG S C | 2004 | J Biol Chem2004，279，10： | 1 |
| 13 | Deforestation Impacts of Environmental Serviees Payments: Costa Rica' s PSA Program 2000 - 2005 显示文摘 | Robalino J Pfaff A Sanchez-Azofeifa G A | 2008 | Environments for Development2008，，1： | 1 |
| 14 | The effec- tiveness of financial incentives for heahh behavior change : systematic review and meta-analysis 显示文摘 | GILES EL ROBALINO S MCCOLL E | 2014 | Plos One2014，9，3： | 1 |
| 15 | Electrocardiographic manifestation of right Ventricnlar infavction显示文摘 | Benjamin D Robalino MD | 1989 | Am Heart J1989，118，1： | 1 |
| 16 | Double-stranded RNA induces sequence-specific antiviral silencing in addition to non- specific immunity in a marine shrimp: convergence of RNA interference and innate immunity in the invertebrate antiviral re- sponse? 显示文摘 | Robalino J Bartlett T Shepard E | 2005 | Journal of Virology2005，79，13： | 1 |
| 17 | Electrocar diograbhic manifestations of right Ventric- ular infarction显示文摘 | Robalino BD Whitlow PL Underwood DA | 1989 | Am Heart J1989，118，： | 1 |
| 18 | Lack of lipotoxicity ef- fect on β-cell dysfunction in ketosis-prone type 2 diabetes显示文摘 | Umpierrez GE Smiley D Robalino G | 2010 | Diabetes Care2010，，33： | 1 |
| 19 | Costa Rica'a Pay- ment for Environmental Services Program: intention, implementation and impact 显示文摘 | Sanchez- Azofeifa G A Pfaff A Robalino J A | 2007 | Conservation Biology2007，21，5： | 1 |
| 20 | Induction of antiviral immunity by double-stranded RNA in a marine invertebrate 显示文摘 | Robalino J Browdy C L Prior S | 2004 | Virology2004，78，10： | 1 |
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