|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Carbon nanotubes for electrochemical biosensing显示文摘 | Rivas G A Rubianes M D Rodriguez M C | 2007 | Talanta2007，74，3： | 1 |
| 3 | 显示文摘 | RUBIANES M D RIVAS G A | 2001 | Anal Chim Acta2001，440，2： | 1 |
| 4 | Carbon nanotubes paste electrode 显示文摘 | Rubianes M D Rivas Gustavo A | 2003 | electrochemistry co- mmunications2003，5，： | 1 |
| 5 | Plant parasiticnematodes associated with guava plantations in Zulia State,Venezuela显示文摘 | Crozzoli P R Casassa P M Rivas G D | 1991 | Fitopatologia Venezolana1991，4，1： | 1 |
| 6 | Double sleeve uniportal video-assisted thoracoscopic lobectomy for non-small cell lung cancer 显示文摘 | GONZALEZ'-RIVAS D DELGADO M FIEIRA E | 2014 | Ann Car- diothorac Surg2014，3，2： | 1 |
| 7 | Genotoxieity study of water-soluble cationic polymers and their polymer-metal complexes with biocidal activity显示文摘 | Rivas B L Pereira E D Mondaca M A | 2003 | J Appl Polym Sci2003，87，3： | 1 |
| 8 | Security on VANETs:Privacy,Misbehaving Nodes,False Information and Secure Data Aggregation显示文摘 | Antolino Rivas D Barcelo-Ordinas J M Guerrero Zapata M | 2011 | Network and Computer Applications2011，34，6： | 1 |
| 9 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 10 | High-frequency resonant SEPIC converter with wide input and output voltage ranges显示文摘 | Hu J Sagneri A D Rivas J M | 2012 | IEEE Transactions on Power Electronics2012，27，1： | 1 |
| 11 | Carbon nanotubes paste electrode 显示文摘 | Rubianes M D Rivas G A | 2003 | Electrochem Commun2003，5，： | 1 |
| 12 | Isothermal calorimetry approach to evaluate shelf life of foods显示文摘 | Riva M Fessas D Schirald i A | 2001 | Thermochimica Acta2001，370，： | 1 |
| 13 | Enzymatic biosensors based on carbon nanotubes paste electrodes 显示文摘 | Rubianes M D Rivas G A | 2005 | Electroanalysis2005，17，： | 1 |
| 14 | Surfactant- synthesized ormosils with application to stone restoration 显示文摘 | Mosquera M J de los Santos D M Rivas T | 2010 | Langrnuir2010，26，9： | 1 |
| 15 | Amperometric biosensor for phenols and catechols based on iridium-polyphenol oxidase-modified carbon paste显示文摘 | RUBIANES M D RIVAS G A | 2000 | Electroanalysis2000，12，14： | 1 |
| 16 | Carbon nanotubes paste electrode显示文摘 | RUBIANES M D RIVAS G A | 2003 | Electrochem Communieat2003，5，8： | 1 |
| 17 | Carbon nanotubes paste electrode显示文摘 | Rubianes M D Rivas Gustavo A | 2003 | electrochemistry communications2003，5，： | 1 |
| 18 | Isothermal calorimetry approach to evaluate shelf life of foods显示文摘 | Riva M Fessas D Schiraldi A | 2001 | Thermochimica Acta2001，370，： | 1 |
| 19 | Amperometric quantification of dopamine using different carbon electrodes modified with a melanintype polymer显示文摘 | Rubianes M D Rivas G A | 2003 | Anal Lett2003，36，： | 1 |
| 20 | Very-high-frequency resonant boost converters显示文摘 | Pilawa-Podgurski R Sagneri A D Rivas J M | 2009 | IEEE Transactions on Power Electronics2009，24，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员