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| 1 | Current trends in management of hepatitis B virus reactivation in the biologic therapy era显示文摘Hepatitis B virus (HBV) reactivation represents an emerging cause of liver disease in patients undergoing treatment with biologic agents. In particular, the risk ofHBV reactivation is heightened by the use monoclonalantibodies, such as rituximab (anti-CD20) and alemtuzumab (anti-CD52) that cause profound and longlasting immunosuppression. Emerging data indicatethat HBV reactivation could also develop following theuse of other biologic agents, such as tumor necrosis factor (TNF)-α inhibitors. When HBV reactivation is di-agnosed, it is mandatory to suspend biologic treatmentand start antiviral agents immediately. However, preemptive antiviral therapy prior to monoclonal antibodyadministration is crucial in preventing HBV reactivationand its clinical consequences. Several lines of evidencehave shown that risk of HBV reactivation is greatlyreduced by the identifi cation of high-risk patients andthe use of prophylactic antiviral therapy. In this article, we discuss current trends in the management of HBV reactivation in immunosuppressed patients receiving biologic therapy, such as rituximab, alemtuzumab and TNF-α antagonists. | Claudio M Mastroianni Miriam Lichtner Rita Citton Cosmo Del Borgo Angela Rago Helene Martini Giuseppe Cimino Vincenzo Vullo | 2011 | World Journal of Gastroenterology2011，17，34： | 12 |
| 2 | Immunosuppression for in vivo research: state-of-the-at protocols and experimental approaches显示文摘几乎,用非自体同源的房间,织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制,抑制免疫力的协议是在移植实验的一个关键元素。然而,没有详细知识,标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当,因此,保证推进调查。这评论与种类特定的药 metabolization 和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇 immunomodulatory 策略的当代的知识,例如间充质的干细胞或抗体的使用。因此,这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和 immunomodulation 策略提高现出症状之前的潜的移植研究的预兆的价值。 | Rita Diehl Fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze | 2017 | Cellular & Molecular Immunology2017，14，2： | 5 |
| 3 | Resin infiltration of deproteinised natural occlusal subsurface lesions improves initial quality of fissure sealing显示文摘The aim of this ex vivo study was to evaluate the infiltration capability and rate of microleakage of a low-viscous resin infiltrant combined with a flowable composite resin(RI/CR) when used with deproteinised and etched occlusal subsurface lesions(International Caries Detection and Assessment System code 2). This combined treatment procedure was compared with the exclusive use of flowable composite resin(CR) for fissure sealing. Twenty premolars and 20 molars revealing non-cavitated occlusal carious lesions were randomly divided into two groups and were meticulously cleaned and deproteinised using Na OCl(2%). After etching with HCl(15%), 10 premolar and 10 molar lesions were infiltrated(Icon/DMG; rhodamine B isothiocyanate(RITC)-labelled) followed by fissure sealing(G-?nial Flo/GC; experimental group, RI/CR). In the control group(CR), the carious fissures were only sealed. Specimens were cut perpendicular to the occlusal surface and through the area of the highest demineralisation(DIAGNOdent pen, Ka Vo). Using confocal laser-scanning microscopy, the specimens were assessed with regard to the percentage of caries infiltration, marginal adaption and internal integrity. Within the CR group, the carious lesions were not infiltrated. Both premolar(57.9% ± 23.1%) and molar lesions(35.3% ± 22.1%) of the RI/CR group were uniformly infiltrated to a substantial extent, albeit with significant differences(P = 0.034). Moreover, microleakage(n = 1) and the occurrence of voids(n = 2) were reduced in the RI/CR group compared with the CR group(5 and 17 specimens,respectively). The RI/CR approach increases the initial quality of fissure sealing and is recommended for the clinical control of occlusal caries. | Andrej M Kielbassa Ina Ulrich Rita Schmidl Christoph Schuller Wilhelm Frank Vanessa D Werth | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 4 | Screening for Gastric Cancer and Surveillance of Premalignant Lesions: a Systematic Review of Cost‐Effectiveness Studies显示文摘 | Miguel Areia Rita Carvalho Ana Teresa Cadime Francisco Rocha Gon?alves Mário Dinis‐Ribeiro | 2013 | Helicobacter2013，，5： | 3 |
| 5 | Assessing the estrogenic potency in a Portuguese wastewater treatment plant using an integrated approach显示文摘The estrogenic potency of a wastewater treatment plant(WWTP) was evaluated using chemical and biological analyses,which showed that after the station treatment processes some of the selected endocrine disruptor compounds(EDCs) were still present in the treated effuent(e.g.,bisphenol A,alkylphenols,estrone) .Thus,the most common endocrine EDCs were identified and quantified and the overall estrogenicity of the treated effuent assessed by integrating the results.Male goldfish(Carassius auratus) were used as biological indicators in a 28-day experiment.Vitellogenin(Vtg) ,gonadosomatic and hepatosomatic indices,steroids(17β-estradiol and 11-ketotestosterone) and histopathology were biomarkers used in fish to evaluate WWTP treated effuent estrogenicity,in combination with instrumental analyses.The results showed a significant increase(P<0.01) in plasma and liver Vtg,which were significantly correlated(r=0.66;P<0.01) .The gonadosmatic index was significantly(P<0.01) reduced in exposed fish.The steroid analyses revealed significant elevations in 17β-estradiol and depressed 11-ketotestosterone concentrations.The histological examinations show changes in exposed fish gonads,such as regressed testes and in some cases(43%to 75%) the development of ovo-testis in fish exposed to 50% and 100% treated effuent. | Mário S.Diniz Rita Maurício Mira Petrovic Maria J.López De Alda Leonor Amaral Isabel Peres Damiá Barceló Fernando Santana | 2010 | Journal of Environmental Sciences2010，22，10： | 2 |
| 6 | Disruption of biofilms from sewage pipes under physical and chemical conditioning显示文摘Biofilms grown inside two sewage collecting pipes located in industrial and residential areas are studied. Bacterial biomass inside three layers of biofilms was evaluated. Biofilm cohesion under different mixing rate and ionic strength was also investigated. Effects of physical and chemical parameters in the biofilms were evaluated by monitoring turbidity,chemical and biochemical oxygen demands. Extracted organic matter from biofilms was partitioned to polar,aromatic and saturated fractions using activated silica column chromatography. Results revealed that bacterial biomass growth depending on biofilm thickness and stratification. The most loaded stratum in bacterial biomass was the sewage-biofilm interface stratum that represented 51% of the total bacterial biomass. Stirring rate and ionic strength of mono-and bivalent salts showed a major influence in biofilm disruption. The stirring time enhanced the exchange dynamic and matter capture between biofilm fragments at the critical stirring rate 90 r/min. Sodium chloride showed the dispersing effect on biofilms in suspension,and decreased the BOD5(biochemical oxygen demand) beyond the physiological salt concentration. | Charbel Mahfoud Antoine El Samrani Rita Mouawad Walid Hleihel Rim El Khatib Bruno S. Lartiges Nam Ouani | 2009 | Journal of Environmental Sciences2009，21，1： | 2 |
| 7 | Msh2,Mlh1,Fhit,p53,Bcl-2 and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix显示文摘 | Rita M Tiziana P | 2000 | Clin Cancer Res2000，6，9： | 1 |
| 8 | The 1,4-Naphthoquinone Scaffold in the Design of Cysteine Protease Inhihitors显示文摘 | CLAUDIA V RUI M RITA C | 2007 | Bioorg Med Chem2007，15，： | 1 |
| 9 | Evolutionary History and Functional Diversification of Phosphomannomutase Genes显示文摘 | Rita Q Ana M Luisa A | | 0，，02： | 1 |
| 10 | Role of bradykinin in myocardial preconditioning 显示文摘 | Theron M Wall Rita Sheehy J Craig Hartman | 1994 | J Pharmacol Exp Ther1994，270，2： | 1 |
| 11 | Genetic analysis and molecular characterisation of laboratory and field mutants of Botryotinia fuckeliana ( Botrytis cinerea ) resistant to QoI fungicides显示文摘 | Rita M De Miccolis Angelini Caterina Rotolo Mario Masiello Stefania Pollastro Hideo Ishii Francesco Faretra | 2012 | Pest Manag Sci2012，，9： | 1 |
| 12 | Antithrombin activity of fucoidan显示文摘 | Frank C James B M Rita E T | 1989 | J Biol Chem1989，264，： | 1 |
| 13 | Solubilization and stabilization of β-carotene in niosomes:delivery to cultured cells显示文摘 | PAOLA P RITA M SONIA T | 2006 | Chem Physics Lipids2006，139，： | 1 |
| 14 | Cross-talk between neurons and astrocytes in response to bilirubin:adverse secondary impacts显示文摘 | Ana Sofia Falc?o Rui F M Silva Ana Rita Vaz | | 0，，： | 1 |
| 15 | Presynaptic functional TrkB receptors mediate the release of excitatory neurotransmitters from primary afferent terminals in lamina II (substantia gelatinosa) of postnatal rat spinal cord 显示文摘 | Adalberto M Rita B Chiara S | 2008 | Develop Neurobiol2008，68，4： | 1 |
| 16 | Enzymatic hydrolysis of sardine (Sardina pilchardus) by-products and lipid recovery 显示文摘 | Irineu B Cristina R Rita M | 2009 | Journal of Aquatic Food Product Technology2009，18，12： | 1 |
| 17 | Personality,basic emotions,and satisfaction:Primary emotions in the mountaineering experience显示文摘 | RITA F KURT M TODD A | | 0，，： | 1 |
| 18 | Antimicrobial edible apple films inactivate antibiotic resistant and susceptible campylobacter jejuni strains on chicken breast显示文摘 | RITA M MIL D LYNN A | 2011 | Journal of Food Science2011，76，3： | 1 |
| 19 | Hypoxic-ischemic injury induce macrophage inflammatory protein-1α expression in immature rat brain 显示文摘 | Rita M Haiyan Xu John MG | 2002 | Stroke2002，33，3： | 1 |
| 20 | Two-phase patitioning bioreactors operating with polymers applied to the removal of substituted phenols 显示文摘 | TOMEI M C ANNESINI M C RITA S | 2010 | Environmental Sciences & Technology2010，44，： | 1 |
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