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| 1 | Can tranexamic acid change preoperative anemia management during total joint arthroplasty?显示文摘AIM: To investigate the postoperative transfusion and complication rates of anemic and nonanemic total joint arthroplasty patients given tranexamic acid(TXA).METHODS: A cross-sectional prospective study was conducted of primary hip and knee arthroplasty cases performed from 11/2012 to 6/2014. Exclusion criteria included revision arthroplasty, bilateral arthroplasty, acute arthroplasty after fracture, and contraindication to TXA. Patients were screened prior to surgery, with anemia was defined as hemoglobin of less than 12 g/d L for females and of less than 13 g/d L for males. Patients were divided into four different groups, based on the type of arthroplasty(total hip or total knee) and hemoglobin status(anemic or nonanemic). Intraoperatively, all patients received 2 g of intravenous TXA during surgery. Postoperatively, allogeneic blood transfusion(ABT) was directed by both clinical symptomsand relative hemoglobin change. Complications were recorded within the first two weeks after surgery and included thromboembolism, infection, and wound breakdown. The differences in transfusion and complication rates, as well as the relative hemoglobin change, were compared between anemic and nonanemic groups.RESULTS: A total of 232 patients undergoing primary joint arthroplasty were included in the study. For the total hip arthroplasty cohort, 21%(18/84) of patients presented with preoperative anemia. Two patients in the anemic group and two patients in the nonanemic group needed ABTs; this was not significantly different(P = 0.20). One patient in the anemic group presented with a deep venous thromboembolism while no patients in the nonanemic group had an acute complication; this was not significantly different(P = 0.21). For nonanemic patients, the average change in hemoglobin was 2.73 ± 1.17 g/d L. For anemic patients, the average change in hemoglobin was 2.28 ± 0.96 g/d L. Between the two groups, the hemoglobin difference of 0.45 g/d L was not significant(P = 0.13). For the total knee arthroplasty cohort, 18%(26/148) of patients presented with preoperative anemia. No patients in either group required a blood transfusion or had an acute postoperative complication. For nonanemic patients, the average change in hemoglobin was 1.85 ± 0.79 g/d L. For anemic patients, the average change in hemoglobin was 1.09 ± 0.58 g/d L. Between the two groups, the hemoglobin difference of 0.76 g/d L was significant(P < 0.001). CONCLUSION: TXA administration results in low transfusion and complication rates and may be a useful adjunct for TJA patients with preoperative anemia. | Duy L Phan Joseph B Rinehart Ran Schwarzkopf | 2015 | World Journal of Orthopedics2015，6，7： | 5 |
| 2 | YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research显示文摘We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database(YPED) that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry(LC–MS/MS) database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring(MRM)/selective reaction monitoring(SRM) assay development. We have linked YPED's database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results. | Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn L.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.Lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry L.Miller Kenneth R.Williams | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 3 |
| 3 | Role of matrix metalloproteinase in failure to re-epithelization after corneal injury显示文摘 | Fini ME Porks WC Rinehart WB | 1996 | Am J Pathol1996，149，9： | 1 |
| 4 | WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatasedependent pathway显示文摘 | De Los Heros P Kahle KT Rinehart J | 2006 | Proc Natl Acad Sci U S A2006，103，6： | 1 |
| 5 | Structure and biosynthesis of toxins from bluegreen algae (cyanobacteria)显示文摘 | RINEHART K L NAMIKOSHI M CHIO B W | 1994 | Journal of Applied Phycology1994，6，： | 1 |
| 6 | Pretreatment with dexamethasone increases antitumor activity of carboplatin and gemcitabine in mice bearing human cancer xenografts:in vivo activity,pharmacokinetics,and clinical implications for cancer chemotherapy显示文摘 | Wang H Li M Rinehart J J | 2004 | Clin Cancer Res2004，10，5： | 1 |
| 7 | Up-regulation of heat shock proteins is essential for cold survival during insect diapause 显示文摘 | Rinehart J P Li A Yocum G D | 2007 | Proceedings of the National Academy of Sci- ences2007，104，11： | 1 |
| 8 | The spectrum of severe preeclampsia: Comparative analysis by HELLP syndrome classification 显示文摘 | Martin JN Jr Rinehart B May WL | 1999 | Am J Obstet Gyneeol1999，180，： | 1 |
| 9 | Identification and preparation of damavaricins,biologically active precursors of streptovaricins显示文摘 | RINEHART K L ANTOSZ F J DESHMUKH P V | 1976 | J Antibiot1976，29，2： | 1 |
| 10 | Three-dimensional storm motion detection by conventional weather radar显示文摘 | Rinehart R E Garvery E T | 1978 | Nature1978，273，： | 1 |
| 11 | Expression of the placental cytokines tumor necrosis factor alpha, inter-leukinl beta, and interleukin10 is increased in preeclampsia 显示文摘 | Rinehart BK Terrone DA Lagoo-Deenadayalan S | 1999 | Am J Obstet Gynecol1999，181，： | 1 |
| 12 | Pharmacokinetic actions of exendin- 4 in the rat: comparison with glucagon-like peptide-1 显示文摘 | Parkes D Jodka C Smith P Nayak S Rinehart L Gingerich R | 2001 | Drug Dev Res2001，53，2： | 1 |
| 13 | Measurement of sarcoplasmic reticulum Ca2+ ATPase activity using high-performance liquid chromatography显示文摘 | WilLIAMS JH VIDT SE RINEHART J | 2008 | Anal Biochem2008，372，2： | 1 |
| 14 | Pretreatment with dexamethasone increases antitumor activity of carboplatin and gemcitabine ha mice bearing human cancer xenografts: in vivo activity, pharmacokinetics, and clinical implications for cancer chemotherapy显示文摘 | Wang H Li M Rinehart JJ | 2004 | Clin Cancer Res2004，10，5： | 1 |
| 15 | Didemnins and tunichlorin:novel natural products from the marine tunicate Trididemnum solidum显示文摘 | Kishore V Bible KC | 1988 | J Nat Prod1988，51，： | 1 |
| 16 | Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression显示文摘 | Biswas S Guix M Rinehart C | 2007 | Clin Invest2007，117，5： | 1 |
| 17 | Sites of regulated phospholylation that control K - C1 cotransport- er activity显示文摘 | Rinehart J Maksimova Y D Tanis J E | 2009 | Cell2009，138，： | 1 |
| 18 | Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate 显示文摘 | Rinehart K L Gloer J B Cook J C | 1981 | J Am Chem Soe1981，103，7： | 1 |
| 19 | Evaluation of fetal protection against experimental infection with type 1 and type 2 bovine viral diarrhea virus after vaccination of the dam with a bivalent modified-live virus vaccine显示文摘 | Fairbanks KK Rinehart CL Ohnesorge WC | 2004 | J Am Vet Med Assoc2004，225，12： | 1 |
| 20 | Structures of the didemnins,antiviral and cytotoxic depsipeptides from a carib bean tunicate显示文摘 | Rinehart K L Gloer J B Cook J C | 1981 | J Am Chem Soc1981，103，7： | 1 |
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