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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 3 | Multiple organ dysfunction score:a reliable description of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 4 | Arthroscopic verification of ultrasonographic diagnosis of meniscal pathology in dogs显示文摘 | Mahn M M Cook J L Cook C R | 2005 | Vet Surg2005，34，4： | 1 |
| 5 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 6 | National Ignition Facility target design and fabrication显示文摘 | COOK R C KOZIOZIEMSKI B J NIKROO A | 2008 | Laser and Particle Beams2008，26，3： | 1 |
| 7 | Results of the pilot studyfor the Hypertension in the Very Elderly Trial显示文摘 | Bulpitt C J Beckett N S Cooke J | 2003 | J Hypertens2003，21，12： | 1 |
| 8 | Systematic reviews: synthesis of best evidence for clinical decisions 显示文摘 | COOK D J MULROW C D HAYNES R B | 1997 | Aim Intern Med1997，126，5： | 1 |
| 9 | Fractionation of polyethylene显示文摘 | FRSNCIS P S COOKE R C Jr ELLIOTT J H | 1958 | J Polym Sci1958，31，123： | 1 |
| 10 | The gamblers fallacy in lottery play 显示文摘 | CLOTFELTER C T COOK P J | 1993 | Manag Sci1993，39，12： | 1 |
| 11 | Probiotics in prevention of antibiotic-associated diarrhoea: meta-analysis显示文摘 | D'Souza AL Rajkumar C Cooke J | 2002 | BMJ2002，324，7350： | 1 |
| 12 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 13 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Science1999，41，3： | 1 |
| 14 | The deuterium to hydrogen ratios of sap in trees: implications for water sources and tree ring deuterium to hydrogen ratios显示文摘 | White J W C Cook E R Lawrence J R | 1985 | Geochimica Et Cosmochimiea Aeta1985，49，： | 1 |
| 15 | Uncertainties for endocrine disrupters: our view on progress显示文摘 | Daston G P Cook J C Kavlock R J | 2003 | Toxicological Sciences2003，74，2： | 1 |
| 16 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 17 | Use of scanning microphotometer to determine the evaporative heat transfer characteristics of the contact line region显示文摘 | Cook R Tung C Y Wayner J P C | 1981 | Journal of Heat Transfer1981，103，2： | 1 |
| 18 | LX-17 comer turning显示文摘 | Souers P C Andreski H G Cook C FⅢ Garza R Pastrone R Phillips D Roeske F Vitello P Molitoris J D | 2004 | Propellants Explosives and Pyrotechnics2004，29，1： | 1 |
| 19 | Survey of veterinary practitioners on PMWS and PDNS in the UK显示文摘 | Gresham A Cook A J C Thomson J R | 2003 | Veterinary Record2003，153，13： | 1 |
| 20 | The reversible reduction of disulfide bonds in polyalanyl ribonuclease 显示文摘 | ANFINSEN C B SELA M COOKE J P | 1962 | J Biol Chem1962，237，： | 1 |
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