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| 1 | Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation显示文摘AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfi de (H2S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice treated with 6-ethyl chenodeoxycholic acid (6E-CDCA), a synthetic FXR ligand. The analysis demonstrated an FXR responsive element in the 5'-flanking region of the human CSE gene. The function of this site was investigated by luciferase reporter assays, chromatin immunoprecipitation and electrophoretic mobility shift assays. Livers obtained from rats treated with carbon tetrachloride alone, or in combination with 6-ethyl chenodeoxycholic acid, were studied for hydrogen sulphide generation and portal pressure measurement. RESULTS: Liver expression of CSE is regulated by bile acids by means of an FXR-mediated mechanism. Western blotting, qualitative and quantitative polymerase chain reaction, as well as immunohistochemical analysis, showed that expression of CSE in HepG2 cells and in mice is induced by treatment with an FXR ligand. Administration of 6E-CDCA to carbon tetrachloride treated rats protected against the down-regulation of CSE expression, increased H2S generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused cirrhotic rat livers. CONCLUSION: These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension. | Barbara Renga Andrea Mencarelli Marco Migliorati Eleonora Distrutti Stefano Fiorucci | 2009 | World Journal of Gastroenterology2009，15，17： | 7 |
| 2 | The bile acid receptor FXR is a modulator of intestinal innate immunity 显示文摘 | Vavassori P Mencareni A Renga B Distrutti E Fiorucci S | 2009 | J Immuneol2009，183，10： | 1 |
| 3 | Hydrogen sulfide generation in mammals: the molecularbiology of cystathionine-beta- synthase (CBS) and cystathionine-gamma-lyase (CSE) 显示文摘 | Renga B | 2011 | Inflamm Allergy Drug Targets2011，10，2： | 1 |
| 4 | Improving motor function in chronic stroke patients using simultaneous occupational thera-py and tDCS显示文摘 | Nair DN Renga V Hamelin S | 2008 | Stroke2008，39，2： | 1 |
| 5 | Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in chole-stasis显示文摘 | Renga B Mencarelli A D'Amore C | 2012 | PLoS One2012，7，30： | 1 |
| 6 | Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid - X - receptor 显示文摘 | Sepe V Bifulco G Renga B | 2011 | Journal of medicinal chemistry2011，54，5： | 1 |
| 7 | The bile acid receptor FXR is a modulator of intestinal innate immunity 显示文摘 | Vavassori P Mencarelli A Renga B | 2009 | J Immunol2009，183，： | 1 |
| 8 | The bile acid receptor FXR is a modulator of intestinal innate im- munity显示文摘 | VAVASSORI P MENCARELLI A RENGA B eta | 2009 | J Immunol2009，183，10： | 1 |
| 9 | Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke显示文摘 | Lindenherg R Renga V Zhu LL | 2010 | Neurology2010，74，4： | 1 |
| 10 | Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor 显示文摘 | Sepe V Bifulco G Renga B | 2011 | J Med Chem2011，54，： | 1 |
| 11 | The methylation of carboxylic acids using methyl, trichloroacetates 显示文摘 | Renga JM Wang PC | 1984 | Synth Commun1984，14，1： | 1 |
| 12 | Experimental studies on R134a DMAC hot water based vapor absorption refrigeration systems显示文摘 | MUTHU V SARAVANAN R RENGA NARARAYANAN V | | 0，，02： | 1 |
| 13 | The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis显示文摘 | Mencarelli A Renga B Migliorati M | | 0，，10： | 1 |
| 14 | Sustained antithrombotic activity of hirudin after its plasma clearance: comparison with heparin 显示文摘 | Agnelli G Renga C Weitz J I | 1992 | Blood1992，80，4： | 1 |
| 15 | Present results and perspectives of allogeneic non-myeloablative hematopoietic stem cell transplantation for treatment of human solid tumors 显示文摘 | Renga M Pedrazzoli P Siena S | 2003 | Ann Oncol2003，14，8： | 1 |
| 16 | Structural integrity of corticospinal motor fibers predicts motor impairment in chronic stroke显示文摘 | Lindenberg R Renga V Zhu LL | 2010 | Neurology2010，74，： | 1 |
| 17 | The bile acid sensor FXR regulates insulin transcription and secretion显示文摘 | Renga B Mencarelli A Vavassori P Brancaleone V Fiorucci S | | 0，，： | 1 |
| 18 | The methyl transferasePRMT1 functions as co-activator of farnesoid X receptor(FXR)/9-cis retinoid X receptor and regulates transcription of FXR respon-sive genes显示文摘 | Rizzo G Renga B Antonelli E | 2005 | Mol Pharmacol2005，68，2： | 1 |
| 19 | Role of FXR in regulating bile acid homeostasis and relevance for human diseases 显示文摘 | Rizzo G Renga B Mencarelli A | 2005 | Curt Drug Targets Immune Endocr Metabol Disord2005，5，3： | 1 |
| 20 | Structural integrity ofcorticospinal motor fibers predicts motor impairment in chron- ic stroke 显示文摘 | Lindenberg R Renga V Zhu LL | 2010 | Neurology2010，74，4： | 1 |
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