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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Synthesis, crystal structure and photophysical properties of europium (III) and terbium(III) complexes with pyridine-2,6-dicar- boxamide 显示文摘 | Stefania T Patrieia M G Rene' de G | 2007 | lnorg Chim Acta2007，360，1： | 1 |
| 4 | Nonlinear behavior of concrete dams using damage mechanics 显示文摘 | FAOUZI G RENE T | 1995 | Journal of Engineering Mechanics1995，121，4： | 1 |
| 5 | Modeling MOV-protected series capacitors for short-circuit studies显示文摘 | Coursol M Chinh T N Rene L | | 0，，01： | 1 |
| 6 | Carbon areogels, cryogels and xerogels: Influence of the drying method on the textural properties of porous carbon materials 显示文摘 | Nathalie J Alexandre T Rene P | 2005 | Carbon2005，43，12： | 1 |
| 7 | Vohwinkel' s syndrome in three generations 显示文摘 | RENEE RS DAYNA GD ZOLTAN T | 2001 | J Am Acad Dermatol2001，44，： | 1 |
| 8 | Hemato-logic and serum biochemical changes in Salmonellaser Typhimurium-iniected calves显示文摘 | Renato L S Renee M T Andreas J B | 2002 | Am J Vet Res2002，63，8： | 1 |
| 9 | Design and control of warehouse order picking: A literature review显示文摘 | RENE D K LE-DUC T KEES J R | 2007 | European Journal of OperationaIReseareh2007，182，2： | 1 |
| 10 | Performance Evaluation of a Compost Biofiher Treating Toluene Vapours 显示文摘 | Rene E R Murthy D V S Swaminathan T | 2005 | Process Biochem2005，40，8： | 1 |
| 11 | Phloem-specific expression of the pumpkin fruit trypsin inhibitor 显示文摘 | Joanne M D Renee C S Gary A T | 2001 | Planta2001，212，1： | 1 |
| 12 | New,uzide-free free trainsformation of epoxides in-tol,2diamino compounds:synthesis lf the anti-irflueuza neu-raminidase inhibitor oselta mivir phosphatc (Taniflu)显示文摘 | Martin k Rene T | 2001 | J Org chem2001，66，： | 1 |
| 13 | Assuring Ethical Treatment of Students as Research Participants显示文摘 | Renee T Ridley PhD | 2009 | Journal of Nursing Education2009，10，48： | 1 |
| 14 | Performance evaluation of a compost biofilter treating toluene vapors 显示文摘 | Rene E R Murthy D V S Swaminathan T | 2005 | Process Biochemistry2005，40，8： | 1 |
| 15 | Modal analysis for damage detection in structures显示文摘 | GEORGE H RENE B T | 1991 | ASCE Journal of Structural Engineering1991，117，10： | 1 |
| 16 | The Genetics of RNA silencing 显示文摘 | MARCEL T RENE F K RONALD H A P | 2002 | Annu Rev Genet2002，36，： | 1 |
| 17 | Using direct contact membrane distillation for whey protein concentration显示文摘 | Knud C Rene A Iben T | 2006 | Desalination2006，200，： | 1 |
| 18 | Endodesmia-diol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides 显示文摘 | Erasmienne T N Rene S F Silvere N | 2008 | Chem Pharm Bull2008，56，3： | 1 |
| 19 | Strategies for reducing maternal mortality in developing countries: what can we learn from the history of the industrialized West? 显示文摘 | Vincent DB Rene T Wim Van L | 1998 | Tropical Medicine and International Health1998，3，7： | 1 |
| 20 | Seismic water pressurein cracked concrete gravity dams:experimental studyand theoretical modeling显示文摘 | Farrokh J Pierre L Rene T | 2005 | Journal of StructureEngineering2005，131，1： | 1 |
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