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| 1 | Clinical significance of Helicobacter pylori cagA and iceA genotype status显示文摘AIM:To study the presence of Helicobacter pylori(H.pylori) virulence factors and clinical outcome in H.pylori infected patients.METHODS:A prospective analysis of ninety nine H.pylori-positive patients who underwent endoscopy in our Endoscopy suite were included in this study.DNA was isolated from antral biopsy samples and the presence of cagA,iceA,and iceA2 genotypes were determined by polymerase chain reaction and a reverse hybridization technique.Screening for H.pylori infection was performed in all patients using the rapid urease test(CLO-Test).RESULTS:From a total of 326 patients who underwent endoscopy for upper gastrointestinal symptoms,99 patients were determined to be H.pylori-positive.Peptic ulceration was seen in 33 patients(33%).The main virulence strain observed in this cohort was the cagA gene isolated in 43 patients.cagA was associated with peptic ulcer pathology in 39.5%(17/43) and in 28%(16/56) of non-ulcer patients.IceA1 was present in 29 patients(29%) and iceA2 in 15 patients(15%).Ulcer pathology was seen in 39%(11/29) of patients with iceA1,while 31%(22/70) had normal findings.The corresponding values for iceA2 were 33%(5/15) and 33%(28/84),respectively.CONCLUSION:Virulence factors were not common in our cohort.The incidence of factors cagA,iceA1 and iceA2 were very low although variations were noted in different ethnic groups. | Nasser Amjad Hussain Ali Osman Najibah Abdul Razak Junaini Kassian Jeffri Din Nasuruddin bin Abdullah | 2010 | World Journal of Gastroenterology2010，16，35： | 7 |
| 2 | Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia显示文摘AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their survival.METHODS:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in Malaysia.The clinical data and associated outcomes were collected using a structured proforma.RESULTS:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 years.Twelve patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal tumors.Only 12 patients underwent curative surgery,including seven R0 resections.Only one patient died within 30 d after surgery.The overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 mo.The overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,respectively.Survival rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient survival.CONCLUSION:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival. | Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud | 2012 | World Journal of Gastroenterology2012，18，5： | 7 |
| 3 | Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer显示文摘Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome. | Muhammad Khairi Ahmad Nur Ainina Abdollah Nurul Husna Shafie Narazah Mohd Yusof Siti Razila Abdul Razak | 2018 | Cancer Biology & Medicine2018，15，1： | 6 |
| 4 | Epithelial-mesenchymal transition as a therapeutic target for overcoming chemoresistance in pancreatic cancer显示文摘Pancreatic cancer has one of the worst prognoses among all cancers due to the late manifestation of identifiable symptoms and high resistance to chemo- and radiation therapies. In recent years, a cancer development phase termed epithelial-mesenchymal transition(EMT) has gained increasing research focus. The process is implicated in tumour metastasis, and emerging evidence suggests EMT also contributes or induces chemoresistance in several cancers. Nevertheless, the applicability of therapeutic targeting of EMT faces many challenges. In this mini-review, we summarise the evidence supporting the role of EMT in pancreatic cancer progression, focusing particularly on its association with chemoresistance. | Omar Elaskalani Norbaini Binti Abdol Razak Marco Falasca Pat Metharom | 2017 | World Journal of Gastrointestinal Oncology2017，9，1： | 6 |
| 5 | 转速对6061-T6铝合金搅拌摩擦搭接焊接头力学性能的影响(英文)显示文摘采用场发射扫描电子显微镜(FE-SEM),研究转速对厚度为5 mm的6061-T6铝合金搅拌摩擦搭接焊接头的宏观和微观组织、硬度、搭接头剪切性能和失效模式的影响。结果表明:在最低的转速度下,上模板和下模板具有十分相似的硬度分布。采用EDX分析发现,焊核区的断裂面中含有Fe的化合物。 | Firouz FADAEIFARD Khamirul Amin MATORI Meysam TOOZANDEHJANI Abdul Razak DAUD Mohd Khairol Anuar Mohd ARIFFIN Norinsan Kamil OTHMAN Farhad GHARAVI Abdul Hadi RAMZANI Farhad OSTOVAN | 2014 | Transactions of Nonferrous Metals Society of China2014，24，4： | 5 |
| 6 | 一种使用静态分析和遗传搜索在Android恶意软件检测中搜索最优特征的方法(英文)显示文摘移动设备制造商在全球范围内快速开发各种Android版本。同时,网络罪犯也在实施各种恶意行为,例如跟踪用户活动、窃取个人数据以及实施银行诈骗。由于在日常生活中使用Android进行重要通信的人群数量庞大,这些网络罪犯从中获得了巨大非法收益。为此,安全从业者通过静态和动态分析对恶意软件进行识别。静态分析具有整体代码覆盖、低资源消耗和快速处理的优势。然而,静态分析需要最少量的特征才能对恶意软件进行有效分类。因此,我们采用基于遗传算法(GA)的遗传搜索(GS)在106个字符串中选择特征。为评估由GS确定的最佳特征,我们使用了5种机器学习分类器,分别是Na?ve Bayes(NB)、功能树(FT)、J48、随机森林(RF)和多层感知器(MLP)。在这5种分类器中,FT仅使用6种特征,获得最高准确度(95%)和最高真正率(TPR)(96.7%)。 | Ahmad FIRDAUS Nor Badrul ANUAR Ahmad KARIM Mohd Faizal Ab RAZAK | 2018 | Frontiers of Information Technology & Electronic Engineering2018，19，6： | 5 |
| 7 | One stop shop:backbones trees for important phytopathogenic genera:Ⅰ(2014)显示文摘Many fungi are pathogenic on plants and cause significant damage in agriculture and forestry.They are also part of the natural ecosystem and may play a role in regulating plant numbers/density.Morphological identification and analysis of plant pathogenic fungi,while important,is often hampered by the scarcity of discriminatory taxonomic characters and the endophytic or inconspicuous nature of these fungi.Molecular(DNA sequence)data for plant pathogenic fungi have emerged as key information for diagnostic and classification studies,although hampered in part by non-standard laboratory practices and analytical methods.To facilitate current and future research,this study provides phylogenetic synopses for 25 groups of plant pathogenic fungi in the Ascomycota,Basidiomycota,Mucormycotina(Fungi),and Oomycota,using recent molecular data,up-to-date names,and the latest taxonomic insights.Lineagespecific laboratory protocols together with advice on their application,as well as general observations,are also provided.We hope to maintain updated backbone trees of these fungal lineages over time and to publish them jointly as new data emerge.Researchers of plant pathogenic fungi not covered by the present study are invited to join this future effort.Bipolaris,Botryosphaeriaceae,Botryosphaeria,Botrytis,Choanephora,Colletotrichum,Curvularia,Diaporthe,Diplodia,Dothiorella,Fusarium,Gilbertella,Lasiodiplodia,Mucor,Neofusicoccum,Pestalotiopsis,Phyllosticta,Phytophthora,Puccinia,Pyrenophora,Pythium,Rhizopus,Stagonosporopsis,Ustilago and Verticillium are dealt with in this paper. | Kevin D.Hyde R.Henrik Nilsson S.Aisyah Alias Hiran A.Ariyawansa Jaime E.Blair Lei Cai Arthur W.A.M.de Cock Asha J.Dissanayake Sally L.Glockling Ishani D.Goonasekara Michal Gorczak Matthias Hahn Ruvishika S.Jayawardena Jan A.L.van Kan Matthew H.Laurence C.AndréLévesque Xinghong Li Jian-Kui Liu Sajeewa S.N.Maharachchikumbura Dimuthu S.Manamgoda Frank N.Martin Eric H.C.McKenzie Alistair R.McTaggart Peter E.Mortimer Prakash V.R.Nair Julia Pawlowska Tara L.Rintoul Roger G.Shivas Christoffel F.J.Spies Brett A.Summerell Paul W.J.Taylor Razak B.Terhem Dhanushka Udayanga Niloofar Vaghefi Grit Walther Mateusz Wilk Marta Wrzosek Jian-Chu Xu JiYe Yan Nan Zhou | 2014 | Fungal Diversity2014，，4： | 3 |
| 8 | Interference-Aware Multipath Routing Protocol for QoS Improvement in Event-Driven Wireless Sensor Networks显示文摘The existing multipath routing protocols for wireless sensor networks demonstrate the efficacy of traffic distribution over multiple paths to fulfill the Quality of Service (QoS) requirements of different applications.However,the performance of these protocols is highly affected by the characteristics of the wireless channel and may be even inferior to the performance of single-path approaches.Specifically,when multiple adjacent paths are being used concurrently,the broadcast nature of wireless channels results in inter-path interference which significantly degrades end-to-end throughput.In this paper,we propose a Low-Interference Energy-efficient Multipath Routing protocol (LIEMRO) to improve the QoS requirements of event-driven applications.In addition,in order to optimize resource utilization over the established paths,LIEMRO employs a quality-based load balancing algorithm to regulate the amount of traffic injected into the paths.The performance gain of LIEMRO compared to the ETX-based single-path routing protocol is 85%,80%,and 25% in terms of data delivery ratio,end-to-end throughput,and network lifetime,respectively.Furthermore,the end-to-end latency is improved more than 60%. | Marjan Radi Behnam Dezfouli Kamalrulnizam Abu Bakar Shukor Abd Razak Mohammad Ali Nematbakhsh | 2011 | Tsinghua Science and Technology2011，16，5： | 3 |
| 9 | Clinical profile of brucellosis from a tertiary care center in southern India显示文摘Objective:To highlight the spectrum of clinical manifestations,labs,complications,treatment and outcome of brucellosis.Methods:Retrospective study was conducted in Kasturba Medical College,Manipal University,Karnataka,India which included 68 confirmed cases of brucellosis from January 2006- April 2010.Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method(or) by testing the sera for Brucella agglutinins using the standard agglutination test(SAT).A titer of 1:320 or more was considered as significant.SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation.Results:Of the 68 patients,46(68%) were male and 22(32%) were female patients with age distribution of 9-75 years.Forty four(64.7%) had history of contact with unpasteurized dairy products or infected animals.Symptoms included fever(68,100%),myalgia(21,31%),musculoskeletal symptoms (23,34%),headache(16,24%),gastrointestinal symptoms(19,28%) and altered sensorium(3, 4%).Co-morbidities and associations included HIV positivity(2,3%),type 2 diabetes mellitus (13,19%),steroid therapy(3,4%) and HBsAg positivity(8,12%).Ten(15%) patients had cervical lymphadenopathy,4(6%) had splenic enlargement,6(7%) had hepatomegaly,19(28%) had hepatosplenomegaly and 2(3%) got meningeal signs.Anaemia was observed in 39(57.3%) cases,high erythrocyte sedimentation rate(ESR) was present in 55(80.8%) cases,leucocytosis in 10(14.7%),leucopenia in 10(14.7%),thrombocytopenia in 23(33.82%) and thrombocytosis in 2(2.94%) cases.Conclusions:In countries like India,where brucellosis and tuberculosis are endemic;rapid,sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy. | Vishwanath Sathyanarayanan Abdul Razak Kavitha Saravu Shastry Barkur Ananthakrishna Mukhyprana Prabhu M Vandana KE | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 3 |
| 10 | Effect of quarry dust addition on the performance of controlled low-strength material made from industrial waste incineration bottom ash显示文摘The performance of industrial waste incineration bottom ash in controlled low-strength material (CLSM) was investigated in this paper, as the quarry dust was added. CLSM mixtures were made from the industrial waste incineration bottom ash, quarry dust, and cement. Tests for fresh density, bleeding, compressive strength, shear strength, hydraulic conductivity, and excavatability were carried out. The com-pressive strength ranges from 60 kPa to 6790 kPa, the friction angle varies from 5° to 19°, and the cohesion is from 4 to 604 kPa. Most of the mixtures are found to be non-excavatable. It is indicated that the quarry dust addition increases the compressive strength and shear parame-ters, decreases bleeding, and increases the removability modulus. | Naganathan Sivakumar Abdul Razak Hashim Abdul Hamid Siti Nadzriah | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，6： | 3 |
| 11 | 基于自主性学习模式的艺术设计专业教学改革研究显示文摘为了进一步推进大学艺术设计专业教学的改革与发展,文章利用文献资料法对自主性学习视角下的大学艺术设计教学管理进行研究。从研究中发现,在大学艺术设计专业教学中构建自主性学习模式,可以有效提升学生的综合能力,对学生的全面发展有着促进作用。可以看出基于自主性学习模式的大学艺术设计专业教学管理,要从培养学生自主的学习能力与意识入手,同时,结合相应的管理机制、管理手段、管理环境,从而创建一个积极、活泼的自主学习氛围,促进学生专业能力的发展。以期学生从被动接受知识向主动发展能力的转变,完善相关管理运行机制,为师生提供自由交流与互动的环境。 | 姚恒 Kamal Abd Razak | 2022 | 工业设计2022，，3： | 2 |
| 12 | Composition of carbohydrates, surfactants, major elements and anions in PM2.5 during the 2013 Southeast Asia high pollution episode in Malaysia显示文摘 | Shoffian Amin Jaafar Mohd Talib Latif Intan Suraya Razak Nurul Bahiyah Abd Wahid Md Firoz Khan Thunwadee Srithawirat | 2018 | Particuology2018，16，2： | 2 |
| 13 | Water Quality Index Using Modified Random Forest Technique: Assessing Novel Input Features显示文摘Water quality analysis is essential to understand the ecological status of aquatic life.Conventional water quality index(WQI)assessment methods are limited to features such as water acidic or basicity(pH),dissolved oxygen(DO),biological oxygen demand(BOD),chemical oxygen demand(COD),ammoniacal nitrogen(NH3-N),and suspended solids(SS).These features are often insufficient to represent the water quality of a heavy metal–polluted river.Therefore,this paper aims to explore and analyze novel input features in order to formulate an improved WQI.In this work,prospective insights on the feasibility of alternative water quality input variables as new discriminant features are discussed.The new discriminant features are a step toward formulating adaptive water quality parameters according to the land use activities surrounding the river.The results and analysis obtained from this study have proven the possibility of predicting WQI using new input features.This work analyzes 17 new input features,namely conductivity(COND),salinity(SAL),turbidity(TUR),dissolved solids(DS),nitrate(NO3),chloride(Cl),phosphate(PO4),arsenic(As),chromium(Cr),zinc(Zn),calcium(Ca),iron(Fe),potassium(K),magnesium(Mg),sodium(Na),E.coli,and total coliform,in predicting WQI using machine learning techniques.Five regression algorithms-random forest(RF),AdaBoost,support vector regression(SVR),decision tree regression(DTR),and multilayer perception(MLP)-are applied for preliminary model selection.The results show that the RF algorithm exhibits better prediction performance,with R2 of 0.974.Then,this work proposes a modified RF by incorporating the synthetic minority oversampling technique(SMOTE)into the conventional RF method.The proposed modified RF method is shown to achieve 77.68%,74%,69%,and 71%accuracy,precision,recall,and F1-score,respectively.In addition,the sensitivity analysis is included to highlight the importance of the turbidity variable in WQI prediction.The results of sensitivity analysis highlight the importance of certain water quality variables that are not present in the conventional WQI formulation. | Wen Yee Wong Ayman Khallel Ibrahim Al-Ani Khairunnisa Hasikin Anis Salwa Mohd Khairuddin Sarah Abdul Razak Hanee Farzana Hizaddin Mohd Istajib Mokhtar Muhammad Mokhzaini Azizan | 2022 | Computer Modeling in Engineering & Sciences2022，，9： | 2 |
| 14 | A mouse model of weight-drop closed head injury:emphasis on cognitive and neurological deficiency显示文摘Traumatic brain injury(TBI) is a leading cause of death and disability in individuals worldwide.Producing a clinically relevant TBI model in small-sized animals remains fairly challenging.For good screening of potential therapeutics,which are effective in the treatment of TBI,animal models of TBI should be established and standardized.In this study,we established mouse models of closed head injury using the Shohami weight-drop method with some modifications concerning cognitive deficiency assessment and provided a detailed description of the severe TBI animal model.We found that 250 g falling weight from 2 cm height produced severe closed head injury in C57BL/6 male mice.Cognitive disorders in mice with severe closed head injury could be detected using passive avoidance test on day 7 after injury.Findings from this study indicate that weight-drop injury animal models are suitable for further screening of brain neuroprotectants and potentially are similar to those seen in human TBI. | Igor Khalin Nor Laili Azua Jamari Nadiawati Bt Abdul Razak Zubaidah Bt Hasain Mohd Asri bin Mohd Nor Mohd Hakimi bin Ahmad Zainudin Ainsah Bt Omar Renad Alyautdin | 2016 | Neural Regeneration Research2016，11，4： | 2 |
| 15 | Secretory expression in Escherichia coli and single-step purification of a heat-stable alkaline protease显示文摘 | Fu Z Hamid S B A Razak C A N | | 0，，： | 1 |
| 16 | Analysis of airflow over building arrays for assessment of urban wind environment显示文摘 | Azli Abd Razak Aya Hagishima | 2013 | Building and Environment2013，，59： | 1 |
| 17 | Dietary pattern and oralcancer risk - a factor analysis study 显示文摘 | Helen LC Razak IA Ghani WM | 2012 | Community Dentistryand Oral Epidemiology2012，40，6： | 1 |
| 18 | HUKM instrumentation system in surgical treatment of adolescent idiopathic scoliosis: An early experience显示文摘 | Fazir M Ibrahim S | 2000 | Med J Malaysia2000，55，： | 1 |
| 19 | Isolation and screening of an extracellular organic solvent-tolerant protease producer显示文摘 | GEOK L P RAZAK C N RAHMAN R N | 2003 | Biochemical Engineering Journal2003，13，： | 1 |
| 20 | Nasopharyngeal carcinoma: the next challenges显示文摘 | Razak AR Siu LL Liu FF | 2010 | Eur J Cancer2010，46，11： | 1 |
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