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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Bleeding outcomes after non-emergency percutaneous coronary intervention in the very elderly显示文摘BackgroundOctogenarians 组成病人为经皮的冠的干预(一种总线标准).MethodsThis 学习评估了的非紧急情况介绍的一个增加的比例在里面医院程序的特征和结果,包括为非紧急情况一种总线标准在 2010 年 1 月和 2012 年 12 月之间介绍给单个大体积的 293 octogenarians 的流血事件第三级的照顾澳大利亚人中心。比较被做, 293 个连续病人,其损害与心肌的梗塞是的 octogenarians.ResultsNon 圣举起被匹配小于等于 60 年变老为在 octogenarians 的非紧急情况一种总线标准的最经常的指示。比作更年轻的队,他们有合作病态和更复杂的冠的疾病的更高的流行,包括更多的类型 C 和钙化的损害。低分子的重量肝磷脂的仙子程序的使用(LMWH;1.0% 对 5.8% ;P < 0.001 ) 并且 glycoprotein IIb/IIIa 禁止者(2.1% 对 9.6% ;P < 0.001 ) 更低,当大腿骨的动脉的存取比在更年轻的病人更通常被使用时(80.9% 对 67.6% ;P < 0.001 ) 。总的来说,向所有流血事件在的更高的发生有一个不重要的趋势老(9.2% 对 5.8% ;P = 0.12 ) 。在存取地点或非存取地点流血和专业或在二个队之间的次要的流血没有重要差别。亚分析没在由 LMWH, glycoprotein IIb/IIIa 禁止者或大腿骨的动脉的存取的使用为率放血上揭示任何重要影响。另外,处于在二 groups.ConclusionsIn 之间的在里面医院死亡,击或尖锐 stent 血栓的率没有重要差别这单个中心研究,我们没包括在经历非紧急情况一种总线标准的 octogenarians 流血的发生在不利在里面医院结果观察重要增加。 | Vimalraj Bogana Shanmugam Dennis T Wong Hashrul Rashid James D Cameron Yuvaraj Malaiapan Peter J Psaltis | 2017 | Journal of Geriatric Cardiology2017，14，10： | 3 |
| 3 | Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend显示文摘The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional andtensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatitewas incorporated into films prepared from a collagen-silk fibroin blend carrying microchannel patternsto stimulate anisotropic osteogenesis. SEM and fluorescence microscopy showed the alignment ofadipose-derived stem cells (ADSCs) and the human osteoblasts (HOBs) on the ridges and in the groovesof microchannel patterned collagen-fibroin-ELR blend films. The Young's modulus and the ultimatetensile strength (UTS) of untreated films were 0.58 ± 0.13 MPa and 0.18 ± 0.05 MPa, respectively. After 28days of cell culture, ADSC seeded film had a Young's modulus of 1.21 ± 0.42 MPa and UTS of0.32 ± 0.15 MPa which were about 3 fold higher than HOB seeded films. The difference in Young'smodulus was statistically significant (p: 0.02). ADSCs attached, proliferated and mineralized better thanthe HOBs. In the light of these results, ADSCs served as a better cell source than HOBs for bone tissueengineering of collagen-fibroin-ELR based constructs used in this study. We have thus shown theenhancement in the tensile mechanical properties of the bone tissue engineered scaffolds by usingADSCs. | Esen Sayin Rosti Hama Rashid JoséCarlos Rodríguez-Cabello Ahmed Elsheikh Erkan Türker Baran Vasif Hasirci | 2017 | Bioactive Materials2017，2，2： | 2 |
| 4 | Mechanism of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity显示文摘 | RASHID S WATANABE T SAKAUE T | 2003 | Clinical Biochemistry2003，36，6： | 2 |
| 5 | Among multiple phosphomanno-mutase gene orthologues,only one gene encodes a protein with phosphoglu-comutase and phosphomannomutase activities in Thermococcus kodakaraen-sis显示文摘 | RASHID N KANAI T ATOMI H | 2004 | J Bacteriol2004，186，： | 1 |
| 6 | Positive psychotherapy 显示文摘 | Seligman MEP Rashid T Parks AC | 2006 | Am Psychol2006，61，8： | 1 |
| 7 | Cardiovascular injuries associated with sternal fractures显示文摘 | Rashid MA Ortenwall P Wikstrom T | 2001 | Eur J Surg2001，167，4： | 1 |
| 8 | Second-order compensated bandgap reference with convex correction 显示文摘 | Avoinne C Rashid T | 2005 | Elec Lett2005，41，5： | 1 |
| 9 | 显示文摘 | Shan A Y Ghazi T I M Rashid S A | 2010 | Appl Catal a Gen2010，389，12： | 1 |
| 10 | A possible link be- tween Crohn's disease and ankylosing spondylitis via Klebsiella infections 显示文摘 | EBRINGER A RASHID T TIWANA H | 2007 | Clin Rheumatol2007，26，3： | 1 |
| 11 | Functions of 5- HT2A receptor and its antagonists in the eardiovaseular system 显示文摘 | Nagatomo T Rashid M Abul Muntasir H | 2004 | Pharmaeol Ther2004，104，1： | 1 |
| 12 | Lovastatin sensitizes lung cancercells to ionizing radiation:modulation of molecular pathways of radioresistance and tumor suppression显示文摘 | Sanli T Liu C Rashid A | 2011 | J Thorac Oncol2011，6，3： | 1 |
| 13 | Second-order Compensated Bandgap Reference with Convex Correction显示文摘 | Avoinne C Rashid T Chowdhury V | 2005 | Electrionics Letters2005，41，5： | 1 |
| 14 | Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity显示文摘 | Rashid S Watanabe T Sakaue T el al | 2003 | Clin Biochem2003，36，6： | 1 |
| 15 | Topical omega-3 and omega-6 fatty acids for treatment of dry eye 显示文摘 | Rashid S Jin Y Ecoiffier T | 2008 | Arch Ophthalmol2008，126，2： | 1 |
| 16 | Improve-ment of Aspergillus oryzae for hyperproduction of endoglu-canase: expression cloning of cmc - 1 gene of Aspergillusaculeatus 显示文摘 | Rashid M H Javed M R Kawaguchi T | 2008 | Biotechnol Lett2008，30，12： | 1 |
| 17 | K-ras mutation, p53 overexpression, and mierosatellite instability in biliary tract cancers: a population-based study in China 显示文摘 | Rashid A Ueki T Gao YT | 2002 | Clin Cancer Res2002，8，10： | 1 |
| 18 | Robot selection by using generalized interval-valued fuzzy numbers with TOPSIS 显示文摘 | Rashid T Beg I Husnine S M | 2014 | Applied Soft Computing2014，21，： | 1 |
| 19 | Thoraic vascular injuries:a major problem in trauma显示文摘 | Rashid MA Wikstrom T Ortenwall P | 2001 | Scand Cardiovas J2001，35，2： | 1 |
| 20 | Effect of degS-degU mutations on the expression of sigD,encoding an alternative sigma factor and autolysin operon of Bacillus subtilis显示文摘 | Tokunaga T Rashid M H Kuroda A | | 0，，16： | 1 |
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