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| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Friction and wear behaviour of cast A1 6063 based in situ metal matrix composites 显示文摘 | RAMESH C S AHAMED A | 2011 | Wear2011，271，： | 1 |
| 3 | Monitoring the structure and dynamics of a dense moist evergreen forest in the Western Ghats(Kodagu District,Kernataka,India)显示文摘 | Elouard C Pascal J-P Pelissier R Ramesh BR Houllier F Durand M Aravjy S Moravie M-A Gimaret-Carpentier | | 0，，02： | 1 |
| 4 | The compressive viscoplastie response of an A359/SiCe metal - matrix composite and the A359 aluminum alloy matrix显示文摘 | Li Y Ramesh K T Chin E S C | 2000 | International Journal of Solids and Structures2000，37，： | 1 |
| 5 | Properties of hydroxylapatite produced by annealing of bovine bone显示文摘 | Ooi C Y Hamdi M Ramesh S | 2007 | Ceramics International2007，33，7： | 1 |
| 6 | Transmissions Analysis by Nash Game Method显示文摘 | Bai X Shahidehpour S M Ramesh V C | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 7 | Synthesis of Vanillin and 4-Hydroxybenz-aldehyde by A Reaction Scheme Involving Condensation of Phenols with Glyoxylic Acid显示文摘 | Rajendra G K Ramesh S D Sampatraj B C | 1986 | J Chem Tech Biotech1986，36，： | 1 |
| 8 | Preparation and charac- terization of floating gellan-chitosan polyelectrolyte complex beads 显示文摘 | Verma A Ramesh C N Sharma S D | 2012 | Latin American Journal of Pharmacy2012，31，1： | 1 |
| 9 | Transaction analysis in deregulated power systems using game theory显示文摘 | Ferrero R W Shahidehpour S M Ramesh V C | 1997 | IEEE Transaction on Power Systems1997，12，3： | 1 |
| 10 | Safe and shelf-stable natural casing using hurdle technology 显示文摘 | Chawla S P Ramesh C Arun S | 2006 | Food Control2006，17，2： | 1 |
| 11 | Neutralization of red mud using CO2 sequestration cycle 显示文摘 | Ramesh C S Raj K P Bankim C R | 2010 | Journal of Hazardous Materials2010，179，： | 1 |
| 12 | The prediction of yam tensile properties by using artificial neural networks 显示文摘 | RAMESH M C RAJAMANICKA R JAYARAMAN S | 1995 | J Text Inst1995，86，3： | 1 |
| 13 | Transmission analysis by nash game method显示文摘 | Shah idehpour S M Ramesh V C | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 14 | Role of Interleukin-2 Regulated Proteins in Immunosuppression by the N-alkylated Prodigiosin Analogue 显示文摘 | Ruchi P Ramesh C Krishna B S | 2007 | International Immunopharmacology2007，7，13： | 1 |
| 15 | A multi-agent technique for contingency constrained optimal power flows 显示文摘 | RAMESH V C | 1994 | IEEE Trans on Power Systems1994，9，2： | 1 |
| 16 | Crisamicin C,a new isochromanequinone antibiotic isolation, structure determination, and biosynthesis 显示文摘 | William L R Ramesh C P Carl P S | 1988 | J Antibiotics1988，41，2： | 1 |
| 17 | Viscoplastic Deformations and Compressive Damage in an a359/SiCp Metal-Matrix Composite显示文摘 | Li Y Ramesh K T Chin E S C | 2000 | Acta Mater2000，48，： | 1 |
| 18 | Dielectric nanocomposites for integral thin film capacitors:materials design,fabrication and integration issues显示文摘 | RAMESH S SHUTZBERG B A HUANG C | 2003 | Advanced Packaging2003，26，1： | 1 |
| 19 | Dynamic characterization of layered and graded structures under impulsive loading显示文摘 | LI Y Ramesh K T Chin E S C | 2001 | International Journal of Solids and Structures2001，38，： | 1 |
| 20 | Viscoplastic defor mation and compressive damage in an A359/SiCp metalmatrix composite显示文摘 | Li Y Ramesh K T Chin E S C | 2000 | Acta Materialia2000，48，7： | 1 |
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