|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genetically modified mouse models for the study of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is associated with obesity,insulin resistance,and type 2 diabetes.NAFLD represents a large spectrum of diseases ranging from(1) fatty liver(hepatic steatosis);(2) steatosis with inflammation and necrosis;to(3) cirrhosis.The animal models to study NAFLD/nonalcoholic steatohepatitis(NASH) are extremely useful,as there are still many events to be elucidated in the pathology of NASH.The study of the established animal models has provided many clues in the pathogenesis of steatosis and steatohepatitis,but these remain incompletely understood.The different mouse models can be classified in two large groups.The first one includes genetically modified(transgenic or knockout) mice that spontaneously develop liver disease,and the second one includes mice that acquire the disease after dietary or pharmacological manipulation.Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex,genetically modified animal models may be a key for the treatment of NAFLD.Ideal animal models for NASH should closely resemble the pathological characteristics observed in humans.To date,no single animal model has encompassed the full spectrum of human disease progression,but they can imitate particular characteristics of human disease.Therefore,it is important that the researchers choose the appropriate animal model.This review discusses various genetically modified animal models developed and used in research on NAFLD. | Perumal Nagarajan M Jerald Mahesh Kuma Ramasamy Venkatesan Subeer S Majundar Ramesh C Juyal M Jerald Mahesh Kuma | 2012 | World Journal of Gastroenterology2012，18，11： | 7 |
| 2 | Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system显示文摘Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we present a case of successful endoscopic closure of a gastrocolic fistula in a severely malnourished patient with complex post-surgical upper GI anatomy. We strongly believe that this device is a major breakthrough for the management of various types of discontinuity defects or fistulas. In addition, we show the usefulness of placing a direct jejunostomy using the double balloon enteroscopy (DBE) technique during the same procedure. The concept of providing direct jejunal feedings while allowing for upper gas-trointestinal bowel rest to promote the healing of the minimally invasive endoscopic operation is novel. Thus, our case is unique and exemplifies the utility of mini-mally invasive endoscopic endoluminal surgery. | Klaus Mnkemüller Shajan Peter Basem Alkurdi Jayapal Ramesh Daniel Popa C Mel Wilcox | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 5 |
| 3 | Graphite nanoplatelet-epoxy composite thermal interface materials显示文摘 | Yu A P Ramesh P hkis M E Bekyarova E Haddon R C | | 0，，： | 1 |
| 4 | Monitoring the structure and dynamics of a dense moist evergreen forest in the Western Ghats(Kodagu District,Kernataka,India)显示文摘 | Elouard C Pascal J-P Pelissier R Ramesh BR Houllier F Durand M Aravjy S Moravie M-A Gimaret-Carpentier | | 0，，02： | 1 |
| 5 | Properties of hydroxylapatite produced by annealing of bovine bone显示文摘 | Ooi C Y Hamdi M Ramesh S | 2007 | Ceramics International2007，33，7： | 1 |
| 6 | Transmissions Analysis by Nash Game Method显示文摘 | Bai X Shahidehpour S M Ramesh V C | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 7 | Enhanced thermal conductivity in a hybrid graphite nanoplatelet-carbon nanotube filler for epoxy composites显示文摘 | Yu A P Ramesh P Sun X B Bekyarova E Itkis M E Haddon R C | | 0，，： | 1 |
| 8 | In vivo effects of a GPR30 antagonist显示文摘 | Dennis M K Burai R Ramesh C | 2009 | Nat Chem Bio12009，5，6： | 1 |
| 9 | Properties ofchitusan films prepared under different drying conditions显示文摘 | Srinivasa P C Ramesh M N Kunar K R | 2004 | Journal ofFood Engineering2004，63，1： | 1 |
| 10 | Evaluation of inoculums addition to stimulate in situ bioremediation of oily-sludge-contaminated soil显示文摘 | Sanjeet M J Jeevan C K Ramesh | 2001 | Applied & Environmental Microbiology2001，67，4： | 1 |
| 11 | Effect of plasticizers and fatty acids on mechanical and permeability characteristics of chitosan films显示文摘 | Srinivasa P C Ramesh M N Tharanathan R N | 2007 | Journal of Food Hydrocolloids2007，21，： | 1 |
| 12 | Removal of copper and cadmium from the aqueous solution by activated carbon derived from Ceiba pentandra hulls显示文摘 | Rao M M Ramesh A Rao G P C | 2006 | Journal of Hazardous Materials2006，129，13： | 1 |
| 13 | In vivo effects of a GPR30 antagonist显示文摘 | Dennis M K Burai R Ramesh C | 2009 | Nature chemical biology2009，5，6： | 1 |
| 14 | A theoretical and experimental investigation of surface generation in diamond turning of an A16061/SiCp metal matrix composite显示文摘 | K C Chan C F Cheung M V Ramesh | 2001 | International Journal of Mechanical Sciences2001，43，： | 1 |
| 15 | Removal of copper and cad-mium from the aqueous solutions by activated carbon derived fromCeiba pentandra hulls显示文摘 | Rao M M Ramesh A Rao G P C | 2006 | Journal of Hazardous Materials2006，129，： | 1 |
| 16 | Transaction analysis in deregulated power systems using game theory显示文摘 | Ferrero R W Shahidehpour S M Ramesh V C | 1997 | IEEE Transaction on Power Systems1997，12，3： | 1 |
| 17 | Use of polymeric plasticizers in polyvinyl chloride to reduce conventional plasticizer migration for critical applications显示文摘 | M C Sunny P Ramesh K E George | | 0，，1： | 1 |
| 18 | Removal of copper and cadmium from the aqueous solutions by activated carbon derived from Ceiba pentandra hulls显示文摘 | Rao M M Ramesh A Rao G P C | | 0，，1： | 1 |
| 19 | The prediction of yam tensile properties by using artificial neural networks 显示文摘 | RAMESH M C RAJAMANICKA R JAYARAMAN S | 1995 | J Text Inst1995，86，3： | 1 |
| 20 | Transmission analysis by nash game method显示文摘 | Shah idehpour S M Ramesh V C | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员