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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Use of a chiA probe for detection of chitinase genes in bacteria from the Chesapeake Bay 显示文摘 | RAMAIAH N HILL R T CHUN J | 2000 | Ferns Microbiol Ecol2000，34，1： | 1 |
| 3 | Postoperative cognitive dysfunction in the eld-erly 显示文摘 | Ramaiah R Lam AM | 2009 | Anesthesiol Clin2009，27，3： | 1 |
| 4 | Isolation and characterization of bergenin derivaves from Macaranga peltata显示文摘 | Ramaiah P A Row L R Reddy D S | 1979 | JCSPerkin 11979，，9： | 1 |
| 5 | Postoperative cognitive dysfunction in the elderly显示文摘 | Ramaiah R Lam AM | 2009 | Anesthesiol C1in2009，27，3： | 1 |
| 6 | Unusual thickening of collarette in Sagitta bedoti (Chaetognatha) from the polluted environments of Bombay coast显示文摘 | Nair V R Nagasawa S Ramaiah N | 1992 | Indian Journal of Marine Sciences1992，21，4： | 1 |
| 7 | Postoperative cognitive dysfunction in the elderly 显示文摘 | RAMAIAH R LAM AM | 2009 | Anesthesiol Clin2009，27，3： | 1 |
| 8 | Postoperative cognitive dysfunction in the elderly显示文摘 | Ramaiah R Lam AM | | 0，，03： | 1 |
| 9 | Postoperative cognitive dysfunction in the elderly显示文摘 | RAMAIAH R LAM A M | 2009 | Anesthesiol Clin2009，27，3： | 1 |
| 10 | Postoperative cognitive dysfunction in the elderly显示文摘 | Ramaiah R Lain AM | 2014 | Anesthesiol Clin2014，27，3： | 1 |
| 11 | Analgesia and sedation for children undergoing burn wound care显示文摘 | Bayat A Ramaiah R Bhananker S M | 2010 | Expert Rev Neu- rother2010，10，： | 1 |
| 12 | Highly efficient one-pot amination of carboxylate-substituted nitrogen- containing heteroaryl chlorides via Staudinger reaction 显示文摘 | Kandalkar S R Kaduskar R D Ramaiah P A | 2013 | Tetrahedron Lett2013，54，： | 1 |
| 13 | Midterm outcomes from the TALON Registry : Treating peripherals with SilverHawk : out- comes collection 显示文摘 | Ramaiah VG Gammon R Kiez S | 2006 | J Endovasc Ther2006，13，5： | 1 |
| 14 | Use of a chiA probe for detection of chitinase genes in bacteria from the Chesapeake Bay显示文摘 | RAMAIAH N HILL R T CHUN J | 2000 | FEMS Microbiol Ecol2000，34，1： | 1 |
| 15 | Analgesia and sedation for children undergoing burn wound care 显示文摘 | Bayat A Ramaiah R Bhananker SM | 2010 | Expert Rev Neurother2010，10，11： | 1 |
| 16 | Pediatric airway management 显示文摘 | Harless J Ramaiah R Bhananker SM | 2014 | Int J Crit Illn Inj Sci2014，4，： | 1 |
| 17 | Postoperative cognitive dysfunction in the elderly显示文摘 | Ramaiah R Lam AM | 2009 | Anesthesiol Clin2009，27，3： | 1 |
| 18 | Postoperative cognitive dysfunction in the elderly显示文摘 | RAMAIAH R LAM A M | 2009 | Anesthesiol Clin2009，27，3： | 1 |
| 19 | Postoperative cognitive dysfunction in the elderly显示文摘 | RAMAIAH R LAM A M | 2009 | Anesthesiol Clin2009，27，3： | 1 |
| 20 | Postoperative cognitive dysfunction in the elderly显示文摘 | RAMAIAH R LAM AM | 2009 | AnesthesM Clin2009，27，3： | 1 |
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