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| 1 | Pancreatic stellate cell: Pandora's box for pancreatic disease biology显示文摘Pancreatic stellate cells(PSCs) were identified in the early 1980 s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smooth muscle actin. PSCs maintain their activated phenotype via an autocrine loop involving different cytokines and contribute to progressive fibrosis in chronic pancreatitis(CP) and pancreatic ductal adenocarcinoma(PDAC). Several pathways(e.g., JAK-STAT, Smad, Wnt signaling, Hedgehog etc.), transcription factors and mi RNAs have been implicated in the inflammatory and profibrogenic function of PSCs. The role of PSCs goes much beyond fibrosis/desmoplasia in PDAC. It is now shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma. These interactions result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance. This is the rationale for therapeutic preclinical and clinical trials that have targeted PSCs and the cancer stroma. | Ratnakar R Bynigeri Aparna Jakkampudi Ramaiah Jangala Chivukula Subramanyam Mitnala Sasikala G Venkat Rao D Nageshwar Reddy Rupjyoti Talukdar | 2017 | World Journal of Gastroenterology2017，23，3： | 25 |
| 2 | Near-infrared flourescent probes:synthesis and spectroscopic investigation of a few amphiphilic squaraine dyes 显示文摘 | Arun T K Ramaiah D | 2005 | Journal of Physical and Chemistry : A2005，109，25： | 1 |
| 3 | Isolation and characterization of bergenin derivaves from Macaranga peltata显示文摘 | Ramaiah P A Row L R Reddy D S | 1979 | JCSPerkin 11979，，9： | 1 |
| 4 | Squaraine dyes for photodynamic therapy: mechanism of cytotoxicity and DNA damage induced by halogenated squaraine dyes plus light (>600 nm) 显示文摘 | Ramaiah D Eckert I Kalliat T | 2004 | Photochem Photobiol2004，79，1： | 1 |
| 5 | Squaraine dyes for photodynamic therapy: mechanism of cytotoxicity and DNA damage induced by halogenated squaraine dyes plus light (>600 nm) 显示文摘 | Ramaiah D Eckert I Arun K T | 2004 | Photochem Photobiol2004，79，1： | 1 |
| 6 | Highly efficient one-pot amination of carboxylate-substituted nitrogen- containing heteroaryl chlorides via Staudinger reaction 显示文摘 | Kandalkar S R Kaduskar R D Ramaiah P A | 2013 | Tetrahedron Lett2013，54，： | 1 |
| 7 | Synthesis of vanillyl - maltoside using glucosidases by response surface methodology显示文摘 | Ramaiah S Balaraman M Soundar D | | EurFoodResTechnol0，226，12： | 1 |
| 8 | Mechanisms of immunemediated liver injury显示文摘 | Adams D H Ju C Ramaiah S K | | 0，，02： | 1 |
| 9 | Site-selective binding and dual mode recognition of serum albumin by a squaraine dye显示文摘 | JISHA V S ARUN K T RAMAIAH D | 2006 | J Am Chem Soc2006，128，18： | 1 |
| 10 | Infrared Absorbing Croconaine Dyes:Synthesis and Metal Ion Binding Properties显示文摘 | Avirah RR Jyothish K Ramaiah D | 2008 | J Org Chem2008，73，1： | 1 |
| 11 | Infrared absorbing croconaine dyes:synthesis and metal ion binding properties 显示文摘 | Avirah R R Jyothish K Ramaiah D | 2008 | J Org Chem2008，73，1： | 1 |
| 12 | Admission oxygenation and venti- lation parameters associated with discharge survival in severe pedi- atric traumatic brain injury 显示文摘 | Ramaiah VK Sharma D Ma L | 2015 | Childs Nerv Syst2015，29，4： | 1 |
| 13 | Synthesis and spectral properties of a variety of 2-styrylbenx-imidazoles显示文摘 | RAMAIAH K DUBEY P K EWSARA R D | 2000 | Indian J Chem B2000，39，12： | 1 |
| 14 | Squaraine dyes for photodynamic therapy: mechanism of cytotoxicity and DNA damage induced by halogenated squaraine dyes plus light (>600 nm)显示文摘 | Ramaiah D Eckert I Arun KT | 2004 | Photochem Photobiol2004，79，1： | 1 |
| 15 | Infrared absorbing croconaine dye: synthesis and metal ion binding properties显示文摘 | Avirah R R Jyothish K Ramaiah D | 2008 | Journal of Organic Chemistry2008，73，： | 1 |
| 16 | The uptake of N, P and K by the cultivars of wheat in the relation to growth and development 显示文摘 | Asana R D Ramaiah P K Ran M V K | 1968 | Indian Journal of Plant Physiology1968，9，： | 1 |
| 17 | Dual-mode semisquaraine-based sensor for selective detection of Hg^2+ in a micellar medium显示文摘 | Avirah R R Jyothish K Ramaiah D | 2007 | Organic Letters2007，9，： | 1 |
| 18 | Isolation and Characterization of Bergenin Derivaves from Macaranga Peltata显示文摘 | Ramaiah P A Row L R Reddy D S | 1979 | J C S Perkin 11979，，9： | 1 |
| 19 | Synthesis of novel quinaldine-based squaraine dyes: effect of substituents and role of electronic factors显示文摘 | Jyothish K Arun K T Ramaiah D | 2004 | Organic Letters2004，6，： | 1 |
| 20 | Structural and optical investigations on CdS thin films grown by chemical bath technique 显示文摘 | Ramaiah K S Pilkington R D Hill A E Tomlinson R D Bhatnagar A K | 2001 | Materials Chemistry and Physics2001，68，13： | 1 |
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