|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation显示文摘Transforming growth factor-beta(TGF-β)/bone morphogenetic protein(BMP) plays a fundamental role in the regulation of bone organogenesis through the activation of receptor serine/threonine kinases. Perturbations of TGF-β/BMP activity are almost invariably linked to a wide variety of clinical outcomes, i.e., skeletal, extra skeletal anomalies, autoimmune, cancer, and cardiovascular diseases. Phosphorylation of TGF-β(I/II) or BMP receptors activates intracellular downstream Smads, the transducer of TGF-β/BMP signals. This signaling is modulated by various factors and pathways, including transcription factor Runx2. The signaling network in skeletal development and bone formation is overwhelmingly complex and highly time and space specific.Additive, positive, negative, or synergistic effects are observed when TGF-β/BMP interacts with the pathways of MAPK, Wnt, Hedgehog(Hh), Notch, Akt/m TOR, and mi RNA to regulate the effects of BMP-induced signaling in bone dynamics. Accumulating evidence indicates that Runx2 is the key integrator, whereas Hh is a possible modulator, mi RNAs are regulators, and b-catenin is a mediator/regulator within the extensive intracellular network. This review focuses on the activation of BMP signaling and interaction with other regulatory components and pathways highlighting the molecular mechanisms regarding TGF-β/BMP function and regulation that could allow understanding the complexity of bone tissue dynamics. | Md Shaifur Rahman Naznin Akhtar Hossen Mohammad Jamil Rajat Suvra Banik Sikder M Asaduzzaman | 2015 | Bone Research2015，3，1： | 53 |
| 2 | Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal显示文摘Diabetes mellitus(DM), a metabolic disorder is a major orchestra influencing brain and behavioral responses via direct or indirect mechanisms. Many lines of evidence suggest that diabetic patients apparently face severe brain complications, but the story is far from being fully understood. Type 2 diabetes, an ever increasing epidemic and its chronic brain complications are implicated in the development of Alzheimer's disease(AD). Evidences from clinical and experimental studies suggest that insulin draws a clear trajectory from the peripheral system to the central nervous system. This review is a spot light on striking pathological, bio-chemical, molecular and behavioral commonalities of AD and DM. Incidence of cognitive decline in diabetic patients and diabetic symptoms in AD patients has brought the concept of brain diabetes to attention. Brain diabetes reflects insulin resistant brain state with oxidative stress, cognitive impairment, activation of various inflammatory cascade and mitochondrial vulnerability as a shared footprint of AD and DM. It has become extremely important for the investigators to understand the patho-physiology of brain complications in diabetes and put intensive pursuits for therapeutic interventions. Although, decades of research have yielded a range of molecules with potential beneficial effects, but they are yet to meet the expectations. | Rajat Sandhir Smriti Gupta | 2015 | World Journal of Diabetes2015，6，12： | 8 |
| 3 | Advances in adjuvant systemic therapy for non-small-cell lung cancer显示文摘Non-small-cell lung cancer remains a leading cause of death around the world. For most cases, the only chance of cure comes from resection for localised disease, however relapse rates remain high following surgery. Data has emerged over recent years regarding the utility of adjuvant chemotherapy for improving disease-free and overall survival of patients following curative resection. This paper reviews the clinical trials that have been conducted in this area along with the studies integrating radiation therapy in the adjuvant setting. The role of prognostic gene signatures are reviewed as well as ongoing clinical trials including those incorporating biological or targeted therapies. | David Leong Rajat Rai Brandon Nguyen Andrew Lee Desmond Yip | 2014 | World Journal of Clinical Oncology2014，5，4： | 7 |
| 4 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 5 | 基于POE的动力学建模与快速非奇异终端滑模控制显示文摘结合旋量指数积形式(POE)和凯恩方程的优点,提出了一种具有明显几何意义的高效动力学建模方法,并以此为基础提出机器人系统的快速非奇异终端滑模控制算法。凯恩方程中的偏速度选择为基于旋量理论描述的合适的物体雅可比矩阵,并以此定义其他动力学模型参数表达方式,且在'钱江一号'串联机器人上进行建模实例验证。基于该动力学模型,为了改善传统滑模控制的有限时间收敛特性,保证全局控制非奇异性,提出了一种快速全局非奇异终端滑模控制,通过构造带状态高次项的滑模面函数,得到全局非奇异控制,并保证系统从任意状态到达滑模面的时间和在滑模上到达平衡点的时间均为有限且快速收敛,通过李雅普诺夫函数证明了其稳定性,并结合对比实验,验证了该方法在机器人系统中的鲁棒性和有效性。 | 陈庆诚 朱世强 Rajat Mittal 张学群 | 2015 | 农业机械学报2015，46，6： | 4 |
| 6 | A new approach for real time object detection and tracking on high resolution and multi-camera surveillance videos using GPU显示文摘High resolution cameras and multi camera systems are being used in areas of video surveillance like security of public places, traffic monitoring, and military and satellite imaging. This leads to a demand for computational algorithms for real time processing of high resolution videos. Motion detection and background separation play a vital role in capturing the object of interest in surveillance videos, but as we move towards high resolution cameras, the time-complexity of the algorithm increases and thus fails to be a part of real time systems. Parallel architecture provides a surpass platform to work efficiently with complex algorithmic solutions. In this work, a method was proposed for identifying the moving objects perfectly in the videos using adaptive background making, motion detection and object estimation. The pre-processing part includes an adaptive block background making model and a dynamically adaptive thresholding technique to estimate the moving objects. The post processing includes a competent parallel connected component labelling algorithm to estimate perfectly the objects of interest. New parallel processing strategies are developed on each stage of the algorithm to reduce the time-complexity of the system. This algorithm has achieved a average speedup of 12.26 times for lower resolution video frames(320×240, 720×480, 1024×768) and 7.30 times for higher resolution video frames(1360×768, 1920×1080, 2560×1440) on GPU, which is superior to CPU processing. Also, this algorithm was tested by changing the number of threads in a thread block and the minimum execution time has been achieved for 16×16 thread block. And this algorithm was tested on a night sequence where the amount of light in the scene is very less and still the algorithm has given a significant speedup and accuracy in determining the object. | Mohammad Farukh Hashmi Ritu Pal Rajat Saxena Avinash G.Keskar | 2016 | Journal of Central South University2016，23，1： | 4 |
| 7 | The response of stromatolites to seismic shocks: Tomboliths from the Palaeoproterozoic Chaibasa Formation, E India显示文摘It is demonstrated here for the first time how Palaeoproterozoic stromatolites survived seismic disturbance of their substrate.The stromatolites under study could have been cyanobacteria or any other photoautotrophic microbes,which formed mats that covered a substrate of very fine-grained sandstones and mudstones of the Chaibasa Fm.in eastern India.The sediments represent a shelf environment.The local abundance of the stromatolites suggests that the low-energy environment formed a suitable habitat.The common phases of tectonic quiescence were,however,occasionally interrupted by seismic shocks.These were sufficiently strong to deform the mat layers,the lower parts of which might already have been(semi-) consolidated.The mats became partly folded,partly faulted,and already consolidated parts of the stromatolite layers broke off.This can be deduced from the angular shapes of part of the broken-off fragments.It appears,however,that part of these fragments were still sufficiently soft to become rounded and deformed by rolling over the seafloor,probably under the influence of tidal currents.When come to rest,these fragments served as a new substrate for new generations of the microorganisms.These micro-organisms thus survived by continued growth on the reworked fragments and built up new stromatolites that may show an 'angular disconformity' with the stromatolites of their substrate.It thus is shown that stromatolites have an adequate response to a sudden disturbance of their habitat,and that they survive earthquakes by colonization of broken-off fragments.We call the'healed'fragments' tomboliths'(tumbled stones). | A.J. (Tom) van Loon Rajat Mazumder Shuvabrata De | 2016 | Journal of Palaeogeography2016，5，4： | 4 |
| 8 | Perioperative Neurological Complications After Liver Transplantation are Best Predicted by Pre-transplant Hepatic Encephalopathy显示文摘 | Rajat Dhar G. Bryan Young Paul Marotta | 2008 | Neurocritical Care2008，，2： | 3 |
| 9 | A review of the~1600 Ma sedimentation,volcanism,and tectono-thermal events in the Singhbhum craton,Eastern India显示文摘The Palaeoproterozoic-Mesoproterozoic transition(~1600 Ma) is a significant event in the Earth history as a global thermal perturbation affected the pre-1600 Ma landmasses.Like other cratonic blocks of the world,lithospheric thinning,sedimentation,magmatism,metamorphism and crustal melting/anatexis are associated with this significant geological event in the Singhbhum cratonic province of India.This paper is a review of sedimentological,magmatic and tectono-thermal events in the Singhbhum craton at~1600 Ma.The Palaeo-Mesoproterozoic sedimentation and volcanism in the Singhbhum craton took place in a terrestrial intracontinental rift setting.The available geochronological data are indicative of late Palaeoproterozoic to Neoproterozoic tectono-thermal events in the Chhotanagpur Granite Gneissic Complex(CGGC),an east-west trending arcuate belt of granite gneisses,migmatites and metasedi-mentary rocks.A detailed multidisciplinary geo-scientific investigation of the Dalma volcanic belt and the area to its north(Chandil Formation) and further north in CGGC will enable us to constrain the extant surface processes and crust-mantle interactions,the collision events between the North and South Indian cratonic blocks,and the position of India in the Columbia supercontinent. | Priyanka Chatterjee Shuvabrata De Marinah Ranaivoson Rajat Mazumder Makoto Arima | 2013 | Geoscience Frontiers2013，4，3： | 2 |
| 10 | Temporal persistence and stability of surface soil moisture in a semi-arid watershed显示文摘 | Michael H. Cosh Thomas J. Jackson Susan Moran Rajat Bindlish | 2007 | Remote Sensing of Environment2007，，2： | 2 |
| 11 | Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and metaanalysis显示文摘BACKGROUND With increasing rates of liver transplantation and a stagnant donor pool,the annual wait list removals have remained high.Living donor liver transplantation(LDLT)is an established modality in expanding the donor pool and is the primary method of liver donation in large parts of the world.Marginal living donors,including those with hepatic steatosis,have been used to expand the donor pool.However,due to negative effects of steatosis on graft and recipient outcomes,current practice excludes overweight or obese donors with more than 10%macro vesicular steatosis.This has limited a potentially important source to help expand the donor pool.Weight loss is known to improve or resolve steatosis and rapid weight loss with short-term interventions have been used to convert marginal donors to low-risk donors in a small series of studies.There is,however,a lack of a consensus driven standardized approach to such interventions.AIM To assess the available data on using weight loss interventions in potential living liver donors with steatotic livers and investigated the feasibility,efficacy,and safety of using such donors on the donor,graft and recipient outcomes.The principal objective was to assess if using such treated donor livers,could help expand the donor pool.METHODS We performed a comprehensive literature review and meta-analysis on studies examining the role of short-term weight loss interventions in potential living liver donors with hepatic steatosis with the aim of increasing liver donation rates and improving donor,graft,and recipient outcomes.RESULTS A total of 6 studies with 102 potential donors were included.Most subjects were males(71).All studies showed a significant reduction in body mass index postintervention with a mean difference of-2.08(-3.06,1.10,I2=78%).A significant reduction or resolution of hepatic steatosis was seen in 93 of the 102(91.2%).Comparison of pre-and post-intervention liver biopsies showed a significant reduction in steatosis with a mean difference of-21.22(-27.02,-15.43,I2=56%).The liver donation rates post-intervention was 88.5(74.5,95.3,I2=42%).All donors who did not undergo LDLT had either recipient reasons or had fibrosis/steatohepatitis on post intervention biopsies.Post-operative biliary complications in the intervention group were not significantly different compared to controls with an odds ratio of 0.96[(0.14,6.69),I2=0].The overall post-operative donor,graft,and recipient outcomes in treated donors were not significantly different compared to donors with no steatosis.CONCLUSION Use of appropriate short term weight loss interventions in living liver donors is an effective tool in turning marginal donors to low-risk donors and therefore in expanding the donor pool.It is feasible and safe,with comparable donor,graft,and recipient outcomes,to non-obese donors.Larger future prospective studies are needed. | Sushrut Trakroo Nakul Bhardwaj Rajat Garg Jamak Modaresi Esfeh | 2021 | World Journal of Gastroenterology2021，27，24： | 2 |
| 12 | Comparison of Single and Combined Treatment with Exenatide and Metformin on Menstrual Cyclicity in Overweight Women with Polycystic Ovary Syndrome显示文摘 | Karen Elkind-Hirsch Ory Marrioneaux Madhu Bhushan Denise Vernor Rajat Bhushan | 2008 | The Journal of Clinical Endocrinology & Metabolism2008，，7： | 2 |
| 13 | Autophagy regulates adipose mass and differentiation in mice显示文摘 | Singh Rajat Xiang Youqing Wang Yongjun Baikati Kiran Cuervo Ana Maria Luu Yen K Tang Yan Pessin Jeffrey E Schwartz Gary J Czaja Mark J | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 14 | An Analysis of Generation Market Power in the Midwest Interconnect显示文摘 | Rajat K. Deb Rafael Emmanuel A. Macatangay Sidart Deb | 2002 | The Electricity Journal2002，，3： | 1 |
| 15 | Performance measurement of sup-ply chain management using the analytical hierarchy process显示文摘 | Rajat Bhagwat Milind Kumar Sharma | 2007 | ProductionPlanning&Control2007，18，8： | 1 |
| 16 | Process and product innovation:complementarity in a vertically differentiated monopoly with discrete consumer types显示文摘 | Swapnendu Bandyopadhyay Rajat Acharyya | 2004 | The Japanese Economic Review2004，55，2： | 1 |
| 17 | Photonic-crystal GaN light-emitting diodes with tailored guided modes distribution显示文摘 | Aurelien David Rajat Sharma T F Kelly McGroddy | 2006 | Applied Physics Letters2006，88，061124： | 1 |
| 18 | Immune responses in chickens against Eimera tenella sporozoite antigen显示文摘 | Rajat Garg Banerjee D P Gupta S K | 1999 | Veterinary Parasitology1999，81，： | 1 |
| 19 | Roughening hexagonal surface morphology on laser lift-off(LLO) N-face GaN with simple photo-enhanced chemical wet etching显示文摘 | Cao Yan Fujii Tetsuo Sharma Rajat | 2004 | Japanese Journal of Applied Physics2004，43，5： | 1 |
| 20 | “The response of stromatolites to seismic shocks: Tomboliths from the Palaeoproterozoic Chaibasa Formation,E India”: Reply显示文摘Our contribution about a newly recognized sedimentological feature, which we called tombolith,has raised some comments on the etymology of the term, the assumed lack of field data, the usage of a term that has a special meaning in stratigraphy, the origin of the seismic shocks that played a role, so-called basic tenets, the origin of soft-sediment deformation structures, and the role of liquefaction. We argue that most comments result from an insufficiently thorough reading of our text, whereas some other remarks concern aspects that we did not deal with. Finally, several remarks are based on outdated literature and from insufficient knowledge of the regional geology. | A.J. (Tom) van Loon Rajat Mazumder Shuvabrata De | 2017 | Journal of Palaeogeography2017，6，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员