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| 1 | Achievements,challenges and global implications of China’s carbon neutral pledge显示文摘China has been committed to achieving carbon neutrality by 2060.China’s pledge of carbon neutrality will play an essential role in galvanising global climate action,which has been largely deferred by the Covid-19 pandemic.China’s carbon neutrality could reduce global warming by approximately 0.2–0.3°C and save around 1.8 million people from premature death due to air pollution.Along with domestic benefits,China’s pledge of carbon neutrality is a“game-changer”for global climate action and can inspire other large carbon emitters to contribute actively to mitigate carbon emissions,particularly countries along the Belt and Road Initiative(BRI)routes.In order to achieve carbon neutrality by 2060,it is necessary to decarbonise all sectors in China,including energy,industry,transportation,construction,and agriculture.However,this transition will be very challenging,because major technological breakthroughs and large-scale investments are required.Strong policies and implementation plans are essential,including sustainable demand,decarbonizing electricity,electrification,fuel switching,and negative emissions.In particular,if China can peak carbon emissions earlier,it can lower the costs of the carbon neutral transition and make it easier to do so over a longer time horizon.China’s pledge of carbon neutrality by 2060 and recent pledges at the 26th UN Climate Change Conference of the Parties(COP26)are significant contributions and critical steps for global climate action.However,countries worldwide need to achieve carbon neutrality to keep the global temperature from growing beyond the level that will cause catastrophic damages globally. | Hong Yang Xianjin Huang Jianlin Hu Julian R.Thompson Roger J.Flower | 2022 | Frontiers of Environmental Science & Engineering2022，16，8： | 2 |
| 2 | Quality of life in Chinese elderly people with depression显示文摘 | Sally W. C.Chan Helen F. K.Chiu Wai‐tongChien David R.Thompson LindaLam | 2006 | Int J Geriat Psychiatry2006，，4： | 1 |
| 3 | Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity显示文摘Exercise benefits the musculoskeletal system and reduces the effects of cancer.The effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence outcomes.Mechanical signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer progression.We examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of vibration.Low-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and RANKL.Furthermore,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive capacity.Disconnecting the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor secretion.LIV increased cell stiffness;an effect dependent on the LINC complex.These data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling. | Xin Yi Laura E.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.Powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid Mohammad Theresa A.Guise William R.Thompson | 2020 | Bone Research2020，8，4： | 1 |
| 4 | Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23显示文摘Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain unclear.Our goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron utilization.Hypoxia-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was suppressed.An inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor cells.Integrative genomics also revealed increased prolyl hydroxylase Egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte differentiation.In mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this model.Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1αblockade.In vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 or-3.In sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable iron.Further,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing. | Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White | 2023 | Bone Research2023，11，1： | 1 |
| 5 | Balancing on Land and at Sea:Do States Ally against the Leading Global Power显示文摘 | Jack S.Levy William R.Thompson | | 0，，01： | 1 |
| 6 | Balancing on Land and at Sea:Do States Ally against the Leading Global Power显示文摘 | Jack S.Levy William R.Thompson | | 0，，01： | 1 |
| 7 | Balancing on Land and at Sea:Do States Ally against the Leading Global Power显示文摘 | Jack S.Levy William R.Thompson | | 0，，01： | 1 |
| 8 | Balancing on Land and at Sea:Do States Ally against the Leading Global Power显示文摘 | Jack S.Levy William R.Thompson | | 0，，01： | 1 |
| 9 | A tabletop X-ray tomography instrument for nanometer-scale imaging: reconstructions显示文摘We show three-dimensional reconstructions of a region of an integrated circuit from a 130 nm copper process.The reconstructions employ x-ray computed tomography,measured with a new and innovative high-magnification x-ray microscope.The instrument uses a focused electron beam to generate x-rays in a 100 nm spot and energy-resolving x-ray detectors that minimize backgrounds and hold promise for the identification of materials within the sample.The x-ray generation target,a layer of platinum,is fabricated on the circuit wafer itself.A region of interest is imaged from a limited range of angles and without physically removing the region from the larger circuit.The reconstruction is consistent with the circuit's design file. | Zachary H.Levine Bradley K.Alpert Amber L Dagel Joseph W.Fowler Edward S.Jimenez Nathan Nakamura Daniel S.Swetz Paul Szypyt Kyle R.Thompson Joel N.Ulom | 2023 | Microsystems & Nanoengineering2023，9，2： | 0 |
| 10 | Using dummy data for RFID tag and reader authentication显示文摘Radio-Frequency IDentification(RFID)technology is an essential enabler of a multitude of intelligent applications.The robust authentication of RFID system components is critical in providing trustworthy data delivery from/to tags.In this paper,we propose an authentication protocol based on monitoring the transmissions between readers and tags in the system.The proposed authentication scheme is based on injecting decoys within the exchanged communications(between RFID readers and tags)and is used in the authentication process.Furthermore,the proposed authentication scheme is mathematically modeled and validated using extensive simulation.The simulations results show that the proposed scheme provides a 100%confidence level in the authentication of tags and detection of compromised readers. | Baha’A.Alsaify Dale R.Thompson Abdallah Alma'aitah Jia Di | 2022 | Digital Communications and Networks2022，8，5： | 0 |
| 11 | 水源价值——尼日利亚北部泛滥平原与大型灌溉工程效益的关系显示文摘当前水资源管理活动,尤其是大型灌溉计划的实施,使非洲许多河流洪积平原逐渐消失或改变了。这些活动对下游湿地效益的影响却往往被忽视。本文通过综合水文和经济分析,模拟尼日利亚北部哈代贾-贾马里(Hadejia-Jama'are)河流域若干大型灌溉系统的不同情况。我们比较了因洪水流量减少给下游农业、渔业和薪炭林造成的损失与因灌溉给上游增产带来的效益。分析结果表明,灌溉收益只能部分地弥补下游因减少水量而受到的损失。考虑到上游一些灌溉工程或竣工或在建设,我们的模拟结果表明,采用定期泻洪的管理方法将是减少进一步损失的最佳方法,同时也应在流域内避免进一步扩大灌溉规模。 | Edward B.Barbier Julian R.Thompson 胡海瑛 | 1998 | 人类环境杂志1998，27，6： | 0 |
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