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| 1 | Influence of the concentration of dietary digestible calcium on growth performance,bone mineralization, plasma calcium, and abundance of genes involved in intestinal absorption of calcium in pigs from 11 to 22 kg fed diets with different concentrations of显示文摘Background: A 21-day experiment was conducted to test the hypothesis that Ca requirements to maximize growth performance expressed as the standardized total tract digestible(STTD) Ca to STTD P ratio is less than 1.40:1. The second hypothesis was that increasing dietary Ca increases plasma Ca concentration and downregulates abundance of genes related to Ca absorption(TRPV6, S100 G, and ATP2 B1) in the duodenum, and tight junction proteins(OCLN, CLDN1, and ZO1) in the duodenum and ileum.Methods: Twenty corn-soybean meal diets were formulated using a 4 × 5 factorial design with diets containing 0.16%, 0.33%, 0.42%, or 0.50% STTD P, and 0.14%, 0.29%, 0.44%, 0.59%, or 0.74% STTD Ca. Six hundred and forty pigs(initial weight: 11.1 ± 1.4 kg) were allotted to 20 diets and 5 blocks in a randomized complete block design. On day21, weights of pigs and feed left in feeders were recorded and blood, duodenal tissue, ileal mucosa, and the right femur were collected from 1 pig per pen. Abundance of m RNA was determined in duodenal and ileal tissue via quantitative RT-PCR. Data were analyzed using a response surface model.Results: The predicted maximum ADG(614 g), G:F(0.65), and bone ash(11.68 g) was obtained at STTD Ca:STTD P ratios of 1.39:1, 1.25:1, and 1.66:1, respectively, when STTD P was provided at the requirement(0.33%). If dietary STTD P was below the requirement, increasing dietary Ca resulted in reduced(P < 0.05) ADG and G:F. However, if dietary STTD P was above the requirement, negative effects(P < 0.05) on ADG and G:F of increasing STTD Ca were observed only if dietary STTD Ca exceeded 0.6%. Plasma Ca concentration was positively affected by STTD Ca over the range studied(quadratic, P < 0.01) and negatively affected by increasing STTD P(linear, P < 0.01). There was a linear negative effect(P < 0.05) of STTD Ca on the abundance of S100 G, TRPV6, OCLN, and ZO1 in duodenum, and CLDN and ZO1 in ileum.Conclusions: The STTD Ca:STTD P ratio needed to maximize growth performance of 11-to 25-kg pigs is less than1.40:1, if P is at the estimated requirement. Increasing dietary Ca reduces transcellular absorption of Ca and increases paracellular absorption of Ca. | L.Vanessa Lagos Su A.Lee Guillermo Fondevila Carrie L.Walk Michael R.Murphy Juan J.Loor Hans H.Stein | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 2 |
| 2 | Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes显示文摘 | J. A.Cross R. C.Temple J. C.Hughes N. C.Dozio C.Brennan K.Stanley H. R.Murphy D.Fowler D. A.Hughes M. J.Sampson | 2010 | Diabetic Medicine2010，，11： | 1 |
| 3 | Ecological and socio‐economic impacts of invasive water hyacinth (Eichhornia crassipes): a review显示文摘 | A. M.VILLAMAGNA B. R.MURPHY | 2010 | Freshwater Biology2010，，2： | 1 |
| 4 | Explaining the Weak Relationship Between Job Performance and Ratings of Job Performance显示文摘 | KEVIN R.MURPHY | 2008 | Industrial and Organizational Psychology2008，，2： | 1 |
| 5 | Ecological and socio‐economic impacts of invasive water hyacinth (Eichhornia crassipes): a review显示文摘 | A. M.VILLAMAGNA B. R.MURPHY | 2010 | Freshwater Biology2010，，2： | 1 |
| 6 | Evaluating the Performance of Third‐Party Logistics Arrangements: A Relationship Marketing Perspective显示文摘 | A. MichaelKnemeyer Paul R.Murphy | 2006 | Journal of Supply Chain Management2006，，1： | 1 |
| 7 | Logistics outsourcing relationships:customer perspectives显示文摘 | A Michael Kneneyer Thomas M.Corsi Paul R.Murphy | | 0，，01： | 1 |
| 8 | Development of effective vaccines against pandemic influenza显示文摘 | Kanta Subbarao Brian R.Murphy Anthony S.Fanci | | 0，，01： | 1 |
| 9 | Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP显示文摘 | Amanda G.Oglesby Erin R.Murphy Vishwanath R.Iyer Shelley M.Payne | 2005 | Molecular Microbiology2005，，5： | 1 |
| 10 | A Machine Learning-Based Distributed Denial of Service Detection Approach for Early Warning in Internet Exchange Points显示文摘The Internet service provider(ISP)is the heart of any country’s Internet infrastructure and plays an important role in connecting to theWorld WideWeb.Internet exchange point(IXP)allows the interconnection of two or more separate network infrastructures.All Internet traffic entering a country should pass through its IXP.Thus,it is an ideal location for performing malicious traffic analysis.Distributed denial of service(DDoS)attacks are becoming a more serious daily threat.Malicious actors in DDoS attacks control numerous infected machines known as botnets.Botnets are used to send numerous fake requests to overwhelm the resources of victims and make them unavailable for some periods.To date,such attacks present a major devastating security threat on the Internet.This paper proposes an effective and efficient machine learning(ML)-based DDoS detection approach for the early warning and protection of the Saudi Arabia Internet exchange point(SAIXP)platform.The effectiveness and efficiency of the proposed approach are verified by selecting an accurate ML method with a small number of input features.A chi-square method is used for feature selection because it is easier to compute than other methods,and it does not require any assumption about feature distribution values.Several ML methods are assessed using holdout and 10-fold tests on a public large-size dataset.The experiments showed that the performance of the decision tree(DT)classifier achieved a high accuracy result(99.98%)with a small number of features(10 features).The experimental results confirmthe applicability of using DT and chi-square for DDoS detection and early warning in SAIXP. | Salem Alhayani Diane R.Murphy | 2023 | Computers, Materials & Continua2023，76，8： | 0 |
| 11 | Antitangling and manufacturable Fog Harps for high‐efficiency water harvesting显示文摘Fog Harps harvest substantially more water than conventional mesh‐based harvesters.However,to date,all large‐scale Fog Harps have been impractically hand‐wound at low wire tensions and suffer from elastocapillary wire tangling.Here,we develop large‐scale and high‐tension Fog Harps that are manufacturable and antitangling.These Fog Harps retain the record‐setting fog harvesting efficiency(η≈17%)of their optimized scale‐model counterparts,while uniquely enabling practical real‐life implementation.Manufacturability was achieved by adapting the industrial process for making harp screens,a pre‐existing technology used for screening solid materials.The critical tension required to minimize wire tangling was rationalized by an improved elastocapillary tangling model. | Jimmy K.Kaindu Kevin R.Murphy Nicholas G.Kowalski Alexandra N.Jones Matthew Davis Fleming Brook S.Kennedy Jonathan B.Boreyko | 2023 | Droplet2023，2，4： | 0 |
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