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| 1 | Innate and adaptive T cells in influenza disease显示文摘流行性感冒是一个主要全球健康问题,引起呼吸的道的感染,经常导致急性肺病,威胁生活的复杂并发症甚至死亡。在最后七十年,种痘策略被利用了保护人免受流行性感冒的复杂并发症的伤害,特别在严重疾病的高风险的组。当当前的种痘政体得到紧张特定的抗体回答时,他们没能产生对季节、流行、鸟的病毒跨保护。而且,设计产生流行性感冒特定的 T 房间回答的疫苗还有待于被优化。在自然感染期间,在适应有免疫力的回答(T 细胞和生产抗体的 B 细胞) 完成病毒的清理和宿主恢复以前,病毒的复制被天生的免疫开始控制。适应 T 和 B 房间维持免疫学的记忆并且对随后的感染向保护提供相关流行性感冒病毒。最近的研究也在控制流行性感冒并且连接天生、适应的有免疫力的机制使天生的 T 房间(MAIT 房间, gd T 房间,和 NKT 房间) 的角色清楚些,因此为种痘策略使他们成为吸引人的目标。我们象适应 CD8 + 和 CD4 + T 房间一样在流行性感冒特定的天生的 MAIT 和 gd T 房间上总结当前的知识,并且讨论这些回答怎么能被新奇疫苗的策略利用对不同流行性感冒紧张和子类型得到跨 protective 免疫。 | Simone Nfissing Sneha Sant Marios Koutsakos Kanta Subbarao Thi H.O. Nguyen Katherine Kedzierska | 2018 | Frontiers of Medicine2018，12，1： | 5 |
| 2 | Hsp70 confines tumor progression of rat histiocytoma and impedes the cytotoxicity induced by natural killer cells and peritoneal macrophages显示文摘Objective:To study the role of inducible form of heat shock protein 70(Hsp70) in the host tumor regression of rat tumor model.Methods:We examined the role of Hsp70 in host tumorigenicity and in vitro cellular cytotoxicity using a rat histocytoma.The differential tumor growth and regression kinetics were studied and correlated with the expression of Hsp70,activation of macrophages and natural killer(NK) cells,and circulating or tumor infiltrating immune molecules in the host system.Results:The sub cuteaneous(s.c.) tumor regression was correlated with increased serum cytokines such as IL-12,TNF P,IFNγand Hsp70.Despite of similar increase of Hsp70 in intraperitoneal(i.p.) tumor implanted animals,animals succumb to tumor growth,further,evidently,no immune molecule activation was observed.The viral promoter driven Hsp70 over expression in these tumor cells restrained solid tumor growth,however,failed to inhibit ascites growth.The NK cells from s.c.immunized animals induces cytotoxicity in the presence of anti-tumor antibody,which necessitated CD40-L expression,conversely,NK cells from i.p.immunized animals failed to induce cytotoxicity.The NK cells from s.c.or i.p.implanted animals with Hsp70 positive tumor cells failed to induce such cytotoxicity.The peritoneal macrophages isolated from s.c.tumor implanted animals when co-cultured with parental BC-8 cells lyses tumor cells,nevertheless entail macrophage specific TNFαexpression.On the contrary,Hsp70 expressing BC-8 tumor cells were resistant to peritoneal macrophage induced cytolysis.Conclusions:This study brings out that Hsp70 possibly involved in regulating the host tumor response and cellular cytotoxicity. | Amere Subbarao Sreedhar | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 5 |
| 3 | Nitrogen Release from Slow-Release Fertilizers in Soils with Different Microbial Activities显示文摘Soil microbial activity is recognized as an important factor affecting nitrogen (N) release from slow-release fertilizers. However,studies on the effect of size and activity of soil microflora on fertilizer degradation have provided contrasting results. To date, no clear relationships exist between soil microbial activity and the release of N from slow-release fertilizers. Hence, the aim of this study was to better understand such relationships by determining the release of N from three slow-release fertilizers in soils with different microbial activities. Soils were amended with urea-formaldehyde (UF), isobutylidene diurea (IBDU), and crotonylidene diurea (CDU). Urea, a soluble fertilizer, was used as the control. Fertilized soil samples were placed in a leaching system, and the release of N was determined by measuring ammonium-N and nitrate-N concentrations in leachates during 90 d of incubation. Non-linear regression was used to fit N leaching rate to a first-order model. In all the treated soils, N was released in the order: urea (89%–100%) > IBDU (59%–94%) >UF (46%–73%) > CDU (44%–56%). At the end of incubation, N released from CDU did not differ (P > 0.05) among soils. On the contrary, UF and IBDU released significantly lower (P < 0.05) amounts of N in the soil with higher microbial activity and lower pH.The rate constant (K_0) for UF was lower (P < 0.05) in the soil with lower pH. Taken together, our results indicated that soil microbial size and microbial activity had a marginal effect on fertilizer mineralization. | Pierfrancesco NARDI Ulderico NERI Giovanni DI MATTEO Alessandra TRINCHERA Rosario NAPOLI Roberta FARINA Guntur V. SUBBARAO Anna BENEDETTI | 2018 | Pedosphere2018，28，2： | 4 |
| 4 | Avian influenza H7N9 viruses: a rare second warning显示文摘 | Kanta Subbarao | 2018 | Cell Research2018，28，1： | 4 |
| 5 | Heat and mass transfer study in fluidized bed granulation-Prediction of entry length显示文摘Fluidized bed granulation is a process by which granules or coated particles are produced in a single piece of equipment by spraying a binder as solution, suspension, or melt on the fluidized powder bed. Heat and mass transfer correlation useful for designing a granulator has been derived based on the equivalence of evaporation rate of the liquid to the heat transferred from hot gas to particles: (m/A)Dp2λ/(Lmf(1- εmf)(Tg-Tl)Kg)=hDp/Kg . This equation is applied to data on granulation experiments by different workers to calculate Reynolds number and Nusselt number to obtain a relation between heat and mass transfer from gas to particles during granulation on a logarithmic scale from which the following empirical relation is obtained: Nu = 0.0205Re1.3876 which is comparable to Kothari's correlation Nu = 0.03Re1.3. By using the heat and mass transfer correlation obtained, the entry length, that is the length of granulator up to which effective heat transfer from gas to bed particles takes place, is estimated, which is also validated with experimental study. The correct estimation of entry length is useful in optimal design of a granulator. | Papiya Roy Manish Vashishtha Rajesh Khanna Duvvuri Subbarao | 2009 | Particuology2009，7，3： | 2 |
| 6 | Ferroelectricity in Bi4 Ti3 O12 and its solid solutions 显示文摘 | SUBBARAO E C | 1961 | Phys Rev1961，122，3： | 2 |
| 7 | Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate 显示文摘 | Chen H Subbarao K Swayne D | 2003 | Vaccine2003，21，： | 1 |
| 8 | Noncompaction of the ventricular myocardium显示文摘 | Weiford BC Subbarao VD Mulhern KM | 2004 | Circulation2004，109，24： | 1 |
| 9 | Influenza 显示文摘 | Cox N J Subbarao K | 1999 | Lancet1999，354，： | 1 |
| 10 | Development of effective vaccines against pandemic influenza显示文摘 | Subbarao K Murphy B R Fauci A S | 2006 | Immunity2006，24，1： | 1 |
| 11 | Hydroxyethyl starch macromolecules reduce myocardial reperfusion injury显示文摘 | Zikria B A Subbarao C h Oz M C | 1990 | Arch Surg1990，，： | 1 |
| 12 | Biodegradation of pyridine in a completely mixed activated sludge process显示文摘 | Padoley K V Rajvaidya A S Subbarao T V | | 0，，： | 1 |
| 13 | Poly (vinyl pyrolidone) Coated Silver Nano Powder Via Displacement Reaction显示文摘 | KHANNA P K GOKHALE R SUBBARAO V V V S | 2004 | Journal of Materials Science2004，39，： | 1 |
| 14 | Charaeterization of an avian influenza A(H5N1)virus显示文摘 | Subbarao K KIimov A | 1998 | Science1998，27，9： | 1 |
| 15 | Selection the optimal focus measure for auto focusing and depth fi'om focus 显示文摘 | Subbarao M Kwei T J | 1998 | IEEE Trans on Pattern Analysis and Machine Intelligence1998，20，8： | 1 |
| 16 | Glycine bemine accumulation, ionic and water relations of red-beet at contrasting levels of sodium supply显示文摘 | Subbarao G V Wheeler R M Levine L H | 2001 | J Plant Physiol2001，158，： | 1 |
| 17 | Limitations of electronic compensation for measuring plethysmographic airway resiatance in infants显示文摘 | Subbarao P Hulskamp G Stocks J | 2005 | Pediatr Pulmonol2005，40，： | 1 |
| 18 | Noncompaction of the Ventricular Myocardium显示文摘 | Brian C. Weiford Vijay D. Subbarao Kevin M. Mulhern | 2004 | Circulation: Journal of the American Heart Association2004，，24： | 1 |
| 19 | Trip chainingbehavior in developing countries: A study of Mumbaimetropolitan region, India显示文摘 | SUBBARAO SSV KRISHNA RK | 2013 | European Transport2013，53，3： | 1 |
| 20 | Effects of osmotic potential and temperature on growth of two pathogens of figs and a biocontrol agent显示文摘 | Subbarao K V Miehailides T J Morgan D P | 1993 | Phytopathology1993，83，12： | 1 |
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