| 1 | MicroRNAs in NF-κB signaling显示文摘Nuclear factor κB(NF-κB)is a transcriptional factor that regulates a battery of genes that are critical to innate and adaptive immunity,cell proliferation,inflammation,and tumor development.MicroRNAs(miRNAs)are short RNA molecules of 20-25 nucleotides in length that negatively regulate gene expression in animals and plants primarily by targeting 3′untranslated regions of mRNAs.In this work,we review the convergence of miRNAs and NF-κB signaling and dysregulation of miRNAs and NF-κB activation in human diseases,particularly in cancer.The function of miR-146,miR-155,miR-181b,miR-21,and miR-301a in NF-κB activation and their impact on tumorigenesis are discussed.Given that over 1000 human miRNAs have been identified,rendering miRNAs one of the most abundant classes of regulatory molecules,deciphering their biological function and pathological contribution in NF-κB dysregulation is essential to appreciate the complexity of immune systems and to develop therapeutics against cancer. | Xiaodong Ma Lindsey E.Becker Buscaglia Juanita R.Barker Yong Li | 2011 | Journal of Molecular Cell Biology2011，3，3： | 3 |
| 3 | 对儿童运动代谢的新认识(英文)显示文摘Research in paediatric exercise metabolism has been constrained by being unable to interrogate muscle in vivo.Conventionally,research has been limited to the estimation of muscle metabolism from observations of blood and respiratory gases during maximal or steady state exercise and the analysis of a few muscle biopsies taken at rest or post-exercise.The purpose of this paper is to review how the introduction of 31P-magnetic resonance spectroscopy and breath-by-breath oxygen uptake kinetics studies has contributed to current understanding of exercise metabolism during growth and maturation.Methodologically robust studies using 31P-magnetic resonance spectroscopy and oxygen uptake kinetics with children are sparse and some data are in conflict.However,it can be concluded that children respond to exercise with enhanced oxygen utilization within the myocyte compared with adults and that their responses are consistent with a greater recruitment of type I muscle fibres.Changes in muscle metabolism are age,maturation- and sex-related and dependent on the intensity of the exercise challenge.The introduction of experimental models such as 'priming exercise' and 'work-to-work' transitions provide intriguing avenues of research into the mechanisms underpinning exercise metabolism during growth and maturation. | Neil Armstrong Alan R.Barker | 2012 | Journal of Sport and Health Science2012，1，1： | 0 |
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