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| 1 | Immunomodulatory effects of lactoferrin显示文摘Lactoferrin (Lf ) 是 transferrin 家庭的铁绑定 glycoprotein,它在很生物的液体被表示与在哺乳动物的牛奶特别地高级。它的多重活动在它的能力躺着绑铁并且与主人和病原体的分子、细胞的部件交往。Lf 能绑并且扣押 lipopolysaccharides,因此阻止的支持 inflammatory 小径激活,败血和织物损坏。Lf 也被认为衔接天生、适应的有免疫力的回答的一个藏匿房间的调停人。在最近的年里,大部分被了解了 Lf 由施加它的活动的机制。这评论在理解位于 Lf 的多功能的角色下面的机制总结最近的进展,并且在它的潜在的预防、治疗学的应用上提供一个未来观点。 | Tania SIQUEIROS-CENDON Sigifredo AREVALO-GALLEGOS Blanca Flor IGLESIAS-FIGUEROA Isui Abril GARCiA-MONTOYA Jose SALAZAR-MARTIN EZ Quintin RASCON-CRUZ | 2014 | Acta Pharmacologica Sinica2014，35，5： | 8 |
| 2 | Return to sport following scaphoid fractures:A systematic review and meta-analysis显示文摘BACKGROUND Scaphoid fracture is the most commonly fractured carpal bone in the athletic patient, accounting for over 85% of all sport-related carpal bone fractures, and is particularly common in sports involving high impact injuries to the wrist. The management of such injuries comprises both conservative and surgical techniques, as guided by fracture location and type. Athletes demonstrate a unique challenge with regards to the management of scaphoid fractures due to their requirement to return to sport, as soon as able.AIM To review systemically all studies recording return to sport following scaphoid fractures, to collate information on return rates to sport(RRS) and mean return times(RTS) to sport and to determine differences in sporting outcome for the various treatment methods.METHODS A systematic search of MEDLINE, EMBASE, CINAHAL, Cochrane, Google Scholar, Physiotherapy Evidence Database, SPORTDiscus, Web of Science and Scopus was performed in August 2018 using the keywords 'scaphoid','fracture', 'acute', 'carpal', 'athletes', 'sports', 'non-operative','conservative', 'operative' and 'return to sport'. All studies that recorded RRS and RTS following scaphoid fractures were included. RTS was recorded as the length of time from commencement of either primary conservative management or primary surgical procedure to return to sport.RESULTS Eleven studies were included: Two randomised controlled trials, six retrospective cohort studies and three case series. Seven studies reported on conservative management(n = 77), and eight studies reported on surgical management(n =83). For conservative management, RRS was 90%(69/77), and the mean RTS was9.6 wk. Three studies allowed to return to sport in cast [RRS 89%(25/28); RTS 1.9 wk], and four studies required completion of cast treatment prior to returning to sport [RRS 90%(44/49); RTS 13.9 wk]. Four studies recorded fracture union data:Union rate 85%(47/55); mean time to union 14.0 wk. For surgical management,RRS was 98%(81/83), and RTS was 7.3 wk. Three studies reported on Percutaneous Screw Fixation [RRS 97%(32/33); RTS 6.5 wk], and five studies reported on Open Reduction Internal Fixation [RRS 98%(49/50); RTS 7.9 wk]. Six studies recorded fracture union data: Union rate 97%(69/71); mean time to union9.8 wk. On meta-analysis, RRS(RR = 1.09; 95% confidence interval(CI): 1.00-1.18;P < 0.045), RTS(MD 2.3 wk; 95%CI: 0.79-3.87; P < 0.002), union rates(RR = 1.14;95%CI: 1.01-1.28; P < 0.030) and mean times to union(MD 4.2 wk; 95%CI: 3.94-4.36; P < 0.001) were all significantly better for the surgical cohort compared to the conservative cohort.CONCLUSION Surgical management of scaphoid fractures can provide significantly improved RRS and RTS to sport compared to conservative management. Both treatments,however, remain acceptable options, and athletes should be fully informed of the benefits and risks of both prior to deciding treatment plans. Immediate return to sport in a cast should be avoided due to the significant risk of non-union. | Joaquim S Goffin Quintin Liao Gregory AJ Robertson | 2019 | World Journal of Orthopedics2019，10，2： | 2 |
| 3 | Barrett’s oesophagus: Intestinal metaplasia is not essential for cancer risk显示文摘 | Clive J. Kelty Martin D. Gough Quintin Van Wyk Timothy J. Stephenson Roger Ackroyd | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 2 |
| 4 | Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis显示文摘 | Quintin Kleer C G | 2002 | Cancer Research2002，62，： | 1 |
| 5 | Dexmedetomidine and clonidine: from second - to first - line sedative agents in the critical care setting 显示文摘 | Pichot C Ghignone M Quintin L | 2012 | J Intensive Care Med2012，27，： | 1 |
| 6 | Peer Instruction:A Teaching Method to Foster Deep Understanding显示文摘 | Beth Simon Quintin Cutts | 2012 | Communications of the ACM2012，55，2： | 1 |
| 7 | Gastrointestinal symptomatic outcome after laparoscopic Roux-en-Y gastric bypass显示文摘 | Allen Foster Henry L Laws Quintin H Gonzalez Ronald H Clements | 2003 | Journal of Gastrointestinal Surgery2003，，6： | 1 |
| 8 | Gastrointestinal Symptoms are More Intense in Morbidly Obese Patients and are Improved with Laparoscopic Roux-en-Y Gastric Bypass显示文摘 | Ronald H Clements MD Quintin H Gonzalez MD Allen Foster MD William O Richards MD James McDowell MD Anthony Bondora MPH Henry L Laws MD | 2003 | Obesity Surgery2003，，4： | 1 |
| 9 | Efficacy of atypical antipsychotics in depressive syndromes显示文摘 | Quintin P Thomas P | 2004 | Encephale2004，30，6： | 1 |
| 10 | Dexmedetomidine and clonidine:from second-to first-line sedative agents in the critical care setting?显示文摘 | Pichot C Ghignone M Quintin L | 2012 | J Intensive Care Med2012，27，4： | 1 |
| 11 | 有氧糖酵解是受训免疫的代谢基础显示文摘越来越多的证据显示先天免疫系统也存在免疫记忆能力。2011年,荷兰内梅亨大学的Netea等提出'受训免疫'的概念,以描述能响应继发感染的先天免疫记忆反应。他们建立了'受训免疫'的体外模型,即用白色念珠菌的β葡聚糖诱导人的单核细胞,7 d后细胞能产生针对多种感染源(LPS等)的非特异性保护作用,表现为TNF-a、IL-6等细胞因子表达上调,其形成机制可能与染色质表观修饰变化有关。最近,Netea教授和他的研究团队发现,由mT OR和HIF-1α介导的有氧糖酵解是受训免疫的代谢基础, | 钦可为 韩超峰 Cheng J Quintin RA Cramer KM | 2015 | 中国肿瘤生物治疗杂志2015，22，2： | 1 |
| 12 | Prevention of bone loss by phloridzin, an apple polyphenol, in ovariecto- mized rats under inflammation conditions 显示文摘 | Puel C Quintin A Mathey J | 2005 | Calcified Tissue International2005，77，5： | 1 |
| 13 | Protein kinase Cε: an oncogene and emerging tumor biomarker 显示文摘 | Michael AG Quintin P | 2009 | Mol Cancer2009，8，9： | 1 |
| 14 | Efficacy of atypical antipsychotics in deoressive syndromes 显示文摘 | Quintin P Thomas P | 2004 | Encephale2004，30，6： | 1 |
| 15 | Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentayl anesthesia and endotracheal intubation 显示文摘 | Quintin L Duke PC | 1986 | Anesthesiology,1986;64:32~421986，64，： | 1 |
| 16 | Anesthesia and hyertension: the effect of clonidine on perioperative hemodynamics and isoflurane requirements 显示文摘 | Calvillo Quintin L | 1988 | Anesthesiology,1988;68:707~7161988，68，： | 1 |
| 17 | Efficacy of atypical antipsychotics in depressive syndromes 显示文摘 | Quintin P Thomas P | 2004 | Encephale2004，30，6： | 1 |
| 18 | Dexmedetomidine and Cloni- dine :From Second-to-First-Line Sedative Agents in the Critical Care Setting显示文摘 | Piehot C Ghignone M Quintin L | 2011 | J Intensive Care Med2011，27，： | 1 |
| 19 | The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll pathway activation function显示文摘 | Matskevich AA Quintin J Ferrandon D | 2010 | Eur J Immunol2010，40，： | 1 |
| 20 | : effect of clonidine显示文摘 | Quintin L Viale JP Annat G : Oxygen uptake after major abdominal surgery | 1991 | Anesthesiology1991，74，： | 1 |
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