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| 1 | Human umbilical cord Wharton's Jelly-derived mesenchymal stem cells differentiation into nerve-like cells显示文摘Background The two most basic properties of mesenchymal stem cells (MSCs) are the capacities to self-renew indefinitely and differentiate into multiple cells and tissue types. The cells from human umbilical cord Wharton’s Jelly have properties of MSCs and represent a rich source of primitive cells. This study was conducted to explore the possibility of inducing human umbilical cord Wharton’s Jelly-derived MSCs to differentiate into nerve-like cells.Methods MSCs were cultured from the Wharton’s Jelly taken from human umbilical cord of babies delivered after full-term normal labor. Salvia miltiorrhiza and β-mercaptoethanol were used to induce the human umbilical cord-derived MSCs to differentiate. The expression of neural protein markers was shown by immunocytochemistry. The induction process was monitored by phase contrast microscopy, electron microscopy (EM), and laser scanning confocal microscopy (LSCM) .The pleiotrophin and nestin genes were measured by reverse transcription-polymerase chain reaction (RT-PCR). Results MSCs in the Wharton’s Jelly were easily attainable and could be maintained and expanded in culture. They were positive for markers of MSCs, but negative for markers of hematopoietic cells and graft-versus-host disease (GVHD)-related cells. Treatment with Salvia miltiorrhiza caused Wharton’s Jelly cells to undergo profound morphological changes. The induced MSCs developed rounded cell bodies with multiple neurite-like extensions. Eventually they developed processes that formed networks reminiscent of primary cultures of neurons. Salvia miltiorrhiza and β-mercaptoethanol also induced MSCs to express nestin, β-tubulinⅢ, neurofilament (NF) and glial fibrillary acidic protein (GFAP). It was confirmed by RT-PCR that MSCs could express pleiotrophin both before and after induction by Salvia miltiorrhiza. The expression was markedly enhanced after induction and the nestin gene was also expressed.Conclusions MSCs could be isolated from human umbilical cord Wharton’s Jelly. They were capable of differentiating into nerve-like cells using Salvia miltiorrhiza or β-mercaptoethanol. The induced MSCs not only underwent morphologic changes, but also expressed the neuron-related genes and neuronal cell markers. They may represent an alternative source of stem cells for central nervous system cell transplantation. | MA Lian FENG Xue-yong CUI Bing-lin Frieda Law JIANG Xue-wu YANG Li-ye XIE Qing-dong HUANG Tian-hua | 2005 | Chinese Medical Journal2005，，23： | 103 |
| 2 | 中文大学生版Buss-Perry攻击性量表的修订与信效度分析显示文摘目的:引进Buss-Perry攻击性量表(BPAQ),并在大学生群体中进行修订,用来测量我国大学生的攻击性水平。方法:在不同行政区域的9所综合型大学抽取1722名在校大学生。对样本编号后,奇数组(n=864)被用于探索性因素分析以确认因子结构;偶数组(n=858)被用于对所得维度进行验证性因素分析。用大学生社会技能量表(ChUSSI)和羞涩量表(RCBS)为效标。抽取其中一所大学的165名学生于初评后2周进行重测。结果:通过探索性因素分析,得到由敌意、身体攻击、冲动、易怒性4个分量表(共22个项目)构成的中文大学生版Buss-Perry攻击性量表(CC-BPAQ);验证性因素分析显示数据拟合良好(GFI=0.917,AGFI=0.896,CFI=0.899,RMSEA=0.059);CC-BPAQ的敌意、身体攻击和易怒性分量表得分与ChUSSI得分呈负相关(r=-0.23、-0.19、-0.20,均P<0.01),CC-BPAQ的4个分量表得分均与RCBS得分呈正相关(r=0.45、0.21、0.11、0.32,均P<0.01)。总量表的内部一致性Cronbachα系数为0.89,4个分量表的α系数为0.73~0.85;总量表的重测信度为0.91,4个分量表的重测信度为0.75~0.80。结论:修订后的中文大学生版Buss-Perry攻击性量表具有良好的信度和效度,可以用于大学生的攻击性测量。 | 吕路 高见和至 董冬 WONG Law rence 王翕 | 2013 | 中国心理卫生杂志2013，27，5： | 52 |
| 3 | 我国民事检察的功能定位和权力边界显示文摘我国的民事检察,是在人民代表大会政体制度下检察权对审判权进行有效制约的重要体现。要认识我国民事检察的功能定位和权力边界,应当在全面认识我国民事检察的地位、制度前提、理论基点、基本内容与特征及其基本原则的基础上,正确把握民事检察与司法权威、当事人的民事处分权、民事当事人的诉讼地位、民事裁判的不确定性、'裁判的既判力'原则、诉讼经济原则之间的关系;而要准确界定民事检察权行使的边界,则要正确处理好民事检察权与诉权、审判权、当事人的自力救济权、法院内部的监督制约、检察机关的职务犯罪侦查权之间的关系。2012年民诉法的修改,为中国民事检察制度的未来发展奠定了新的法律基础,也将使检察机关面临着新的问题与挑战。 | Law and Policy Research Office of the Supreme People’s Procuratorate | 2013 | 中国法学2013，，4： | 35 |
| 4 | On the new results of global attractive set and positive invariant set of the Lorenz chaotic system and the applications to chaos control and synchronization显示文摘Constructing a family of generalized Lyapunov functions, a new method is proposed to obtain new global attractive set and positive invariant set of the Lorenz chaotic system. The method we proposed greatly simplifies the complex proofs of the two famous estimations presented by the Russian scholar Leonov. Our uniform formula can derive a series of the new estimations. Employing the idea of intersection in set theory, we extract a new Leonov formula-like estimation from the family of the estimations. With our method and the new estimation, one can confirm that there are no equilibrium, periodic solutions, almost periodic motions, wandering motions or other chaotic attractors outside the global attractive set. The Lorenz butterfly-like singular attractors are located in the global attractive set only. This result is applied to the chaos control and chaos synchronization. Some feedback control laws are obtained to guarantee that all the trajectories of the Lorenz systems track a periodic solution, or globally stabilize an unstable (or locally stable but not globally asymptotically stable) equilibrium. Further, some new global exponential chaos synchronization results are presented. Our new method and the new results are expected to be applied in real secure communication systems. | LIAO Xiaoxin 1, 2, 3 , FU Yuli 4 & XIE Shengli 4 1. Department of Control Science & Control Engineering, Huazhong University of Science & Technology, Wuhan 430074, China 2. School of Automation, Wuhan University of Science & Technology, Wuhan 430070, China 3. School of Information, Central South University of Economy, Politics and Law, Wuhan 430064, China 4. School of Electronics & Information Engineering, South China University of Technology, Guangzhou 510640, China Correspondence should be addressed to Liao Xiaoxin (email: xiaoxin_liao@hotmail.com) | 2005 | Science in China(Series F)2005，48，3： | 23 |
| 5 | Chinese Overseas investment Calls for Perfection of Overseas Investment Insurance显示文摘Overseas investment insurance is a non-profitable insur- ance provided by the government of a state for her enterprises which have invested in the developing countries or areas against political risks.Such a gov- ernmental guarantee system was first established in the United States in the middle of last century.Nowadays most developed countries and some of the developing countries have followed American practices and set up similar systems to encourage their enterprises to make investment in developing areas which are often regarded to be more easily to have political risks.In | Liu Yajun,associateprofessor,tutor of postgraduate,vice dean of the School of International Law of Northwest University of Political Science and Law.His main research orientation includes international trade law and international investment law. | 2008 | China's Foreign Trade2008，，8： | 22 |
| 6 | “互联网+”时代的旅游业巨变显示文摘从"父母在不远游"到"世界这么大,我想出去看看",不同时期的旅游方式无不承载着时代和科技发展的烙印。21世纪以来,随着我国经济水平和人均可支配收入的不断提升,在互联网旅游概念兴起的浪潮中,旅游业发生了天翻地覆的变化。 | 钱建伟 Rob Law | 2016 | 旅游学刊2016，31，6： | 23 |
| 7 | 北京市41~47岁人群出生时发育指标与成年期糖耐量减低的关系显示文摘目的 探讨中国人群中是否存在低出生指标与成年期非胰岛素依赖性糖尿病( N I D D M)和糖耐量减低( I G T) 的联系。方法 对1948 年7 月~1954 年底在北京协和医院出生的628 名单生子进行追访调查,摘录出生记录,并进行身体测量和标准口服葡萄糖耐量试验。结果 N I D D M 和 I G T患病率随出生体重、出生体重指数(ponderal index, P I) 和头围测量值的上升而下降。出生消瘦( P I< 24kg/m3) 伴成年肥胖( B M I≥75 百分位值) 组患病率最高(43 .8 % ) ;出生时脂肪较多( P I≥28 kg/m3) 且成年消瘦( B M I< 25 百分位值) 组患病率最低(8 .3 % ) 。母亲孕早、晚期 B M I与子女成年期糖负荷后2 小时血糖浓度呈负相关。此外,出生体重、 P I和头围还与空腹和糖负荷后2 小时血浆胰岛素、3233 裂解胰岛素原水平呈负相关。对调查对象目前的 B M I、生活习惯和经济水平进行调整后,上述出生指标与成年期糖耐量和胰岛素间的联系依然存在。结论 中国人群中存在低出生指标与成年期 N I D D M 和 I G T的联系,其机制可能是通过母亲孕前低 B M I导致胎儿营养不良,产生胰岛? | 米杰 Law CM 张孔来 Barker DJP 刘善英 Osmond C 徐红健 沈宜 柳军 徐永芳 | 1999 | 中华预防医学杂志1999，33，4： | 21 |
| 8 | Sex differences in cognitive impairment in Alzheimer's disease显示文摘Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge. | Keith R Laws Karen Irvine Tim M Gale | 2016 | World Journal of Psychiatry2016，6，1： | 18 |
| 9 | Patients with Helicobacter pylori positive and negative duodenal ulcers have distinct clinical characteristics显示文摘AIM: To assess the clinical characteristics of Helicobacterpylori(H pylori) negative duodenal ulcer.METHODS: Patients with an endoscopic diagnosis of duodenal ulcer between 1996 and 2002 were included in the present study. Patients were considered to be negative for Hpylori, if both histological examination and rapid urease test of biopsy specimens were negative. A comparison was made between patients with H pyloripositive and negative duodenal ulcers.RESULTS: A total of 1 343 patients were studied. Their mean age was 54.7±0.5 years. There was a male preponderance (M:F = 2.5:1). Three hundred and ninetyeight patients (29.6%) did not have H pylori infection. The annual proportion of patients with H pylori negative duodenal ulcers increased progressively from 1996 to2002. On multivariate analysis, patients with H pylorinegative duodenal ulcer were more likely to be older, have concomitant medical problem, pre-existing malignancy, recent surgery, underlying sepsis, or taken non-steroidal anti-inflammatory drugs. In terms of clinical presentations, patients with H pylori negative duodenal ulcer were more likely to present with bleeding, multiple ulcers and larger ulcers.CONCLUSION: The proportion of patients with H pylori negative duodenal ulcers is on the rise because of a continued drop in incidence of H pylori positive duodenalulcers in recent years. Such patients have distinct clinical characteristics and it is important to ascertain the H pylori status before starting eradication therapy. | Kent-Man Chu Ka-Fai Kwok Simon Law Kam-Ho Wong | 2005 | World Journal of Gastroenterology2005，11，23： | 17 |
| 10 | Common dental diseases in children and malocclusion显示文摘Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Management of oral health in the early childhood stage is carried out in clinic work of pediatric dentistry to minimize the unwanted effect of these diseases on dentition. This article highlights these diseases and their impacts on malocclusion in sequence. Prevention, treatment, and management of these conditions are also illustrated in order to achieve successful oral health for children and adolescents, even for their adult stage. | Jing Zou Mingmei Meng Clarice S Law Yale Rao Xuedong Zhou | 2018 | International Journal of Oral Science2018，10，2： | 16 |
| 11 | 针叶木和阔叶木硫酸盐浆PFI打浆性能的研究显示文摘研究了针叶木和阔叶木硫酸盐浆PFI打浆对各自纤维性质及浆张性能的影响。结果表明,打浆使两种浆纤维长度下降较小,纤维粗度下降较多,同时纤维被拉伸,纤维的卷曲和扭曲系数降低;两者游离度的变化趋于一致;打浆可不同程度地提高两种浆的零距裂断长和抗张指数,而对于撕裂指数,随打浆的进行,针叶木浆的撕裂指数为降低趋势,而相应的阔叶木浆却增加;打浆降低浆料的光学性能如白度、不透明度、光散射系数。 | 韩颖 Kwei-Nam LAW Robert LANOUETTE | 2008 | 中国造纸学报2008，23，1： | 15 |
| 12 | Event-related potentials in a Go/Nogo task of abnormal response inhibition in heroin addicts显示文摘Inhibitory control dysfunction is regarded as a core feature in addicts.The major objective of this study was to explore the time course of response inhibition in chronic heroin addicts and provide the neurophysiological evidence of their inhibitory control dysfunction.The amplitudes and latencies of ERP components were studied in fourteen heroin addicts(mean duration of heroin use being(13.54±5.71) years(Mean±SD),average abstinence being((4.67±6.44) months)) and fourteen matched healthy controls with a visual Go/Nogo task.Our results showed that heroin addicts demonstrated significantly larger Go-N2 amplitudes which results in a decreased N2 Go/Nogo effect,but no statistically significant differences were found between heroin addicts and controls in P3.The ERP data suggest that fronto-central areas of heroin addicts were impaired during the inhibition process(200-300 ms) and over-activated to targets.The impaired early process might reflect an abnormal conflict monitoring process in heroin addicts.These results consolidate the inhibitory control dysfunction hypothesis in chronic heroin users. | YANG Bo1,YANG SuYong2,ZHAO Lun3,YIN LiuHua1,LIU Xu1& AN ShaSha1 1 Laboratory of Psychology,School of Sociology,China University of Political Science and Law,Beijing 102249,China 2 National Key Laboratory of Cognitive Neurosciences and Learning,Beijing Normal University,Beijing 100875,China 3 Institute of Language,Xuzhou Normal University,Xuzhou 221116,China | 2009 | Science China(Life Sciences)2009，52，8： | 15 |
| 13 | SEASONAL AND DIURNAL VARIATIONS OF PM_(1.0),PM_(2.5) AND PM_(10) IN THE ROADSIDE ENVIRONMENT OF HONG KONG显示文摘PM1.0 (fine particles, with diameter < 1 μm), PM2.5 (fine particles, with diameter < 2.5 μm) and PM10 (coarse particles, with diameter < 10 μm) were measured at 24-hour intervals near a high-traffic road in Hong Kong, from October 2004 to September 2005. Mass concentrations were determined for the three particle fractions, averaging for PM1.0, PM2.5 and PM10, respectively, 44.5±18.4, 55.4±25.5 and 81.3±37.7 μg?m-3. PM2.5 was 3.7 times the U.S. EPA’s annual NAAQS of 15 μg?m-3. Overall, PM1.0 accounted for 44 to 69% (average 57%) of PM10, while PM2.5 accounted for 58 to 82% (average 71%) in this study. The particulate masses showed obvious seasonal patterns with high concentrations in cold seasons and low in warm seasons, especially high concentrations of PM2.5-10 during the cold seasons. Diurnal variations of mass concentrations of PM2.5 were determined during July, showing two major peaks in the morning and afternoon rush hours. | K.F. Ho S.C. Lee S.W. Law | 2006 | China Particuology2006，4，6： | 15 |
| 14 | 自然资源(基本)法立法可行性研究报告显示文摘本文立足于我国基本国情,全面分析了自然资源(基本)法立法的客观依据和现实条件,对自然资源(基本)法及替代方案进行了比较研究,在此基础上。 | Research Group of Feasibility Research of the Legislation of Natural Resources Basic law | 1998 | 兰州大学学报(社会科学版)1998，26，3： | 13 |
| 15 | 旅游重要性感知、旅游动机与人口特征:基于香港居民调查数据的实证研究显示文摘本文基于对香港居民的大规模电话调查,采用最优尺度回归模型,探讨出游动机和人口统计特征如何影响香港居民对旅游重要性的感知以及人口统计特征如何影响香港居民的出游动机。回归结果显示:休闲放松和发掘新事物是影响旅游重要性感知的主要旅游动机,家庭月收入和受教育程度是影响旅游重要性感知的主要人口统计特征;与亲朋好友聚会、社交、休闲放松、逃脱日常事务和发掘新事物动机最相关的人口统计特征分别是家庭月收入、年龄、家庭月收入、年龄和受教育程度,而性别对香港居民的各种出游动机无显著影响。 | 张紫琼 Rob Law 刘挺 | 2012 | 旅游科学2012，26，5： | 12 |
| 16 | Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong显示文摘氨基酸,器官的酸和丰满的酸氧化的新陈代谢(IEM ) 的古典先天的错误的背景数据大部分正在缺乏香港,在集体基于 spectrometry 的扩展新生儿为 IEM 屏蔽没被开始的地方。瞄准在香港评估近似发生,光谱和古典 IEM 的另外的特征的当前的学习,将在开发为实验室血浆氨基酸记录的本地 area.Methods 屏蔽节目的一个扩展新生儿重要,血浆 acylcarnitines 和尿从年 2005~2009 的器官的酸分析在为 IEM 提供生物化学、基因的诊断服务的三个地区性的化学病理实验室包括回顾地 reviewed.Resu 在香港的古典 IEM 的发生粗略地被估计每 1000live 出生每 4122 生活出生,或 0.243 个盒子是至少 1 个盒子。这发生类似于全球报导的那些,包括中国的大陆。hyperphenylalaninemia 的估计的发生在 29 542 实时 births.Conclusions 是 1 我们的数据显示它为在香港的扩展新生的屏蔽节目的介绍是无可争辩的。因为香港是一个大城市的城市,一个全面扩展新生的屏蔽程序和工作分派系统应该是可得到的服务在区域出生的出生不满一月的婴儿。 | Han-Chih Hencher Lee Chloe Miu Mak Ching-Wan Lam Yuet-Ping Yuen, Angel On-Kei Chan Chi-Chung Shek Tak-Shing Siu Chi-Kong Lai Chor-Kwan Ching Wai-Kwan Siu Sammy Pak-Lam Chen Chun-Yiu Law Morris Hok-Leung Tai Sidney Tam Albert Yan-Wo Chan | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 17 | 我国内地旅游网站的可用性研究--基于对海口市网民的调查显示文摘目前国内很多针对旅游网站的研究大多是关注旅游网站的功能,网站可用性方面的研究很大程度上被忽视了。本文对此进行了探索性研究:通过采用修正的启发式评价方法,定义了用户对网站评价的基准,对489份基于5大类24个指标的调查问卷进行了分析和讨论,发现了我国内地旅游网站在可用性如内容服务形式、整体结构设计等方面存在的问题,同时给出了解决这些问题的建议和措施。 | 胡涛 Catherine Cheung Rob Law | 2008 | 旅游科学2008，22，4： | 11 |
| 18 | 互联网思维下的人力资源管理创新显示文摘互联网改变着人们的工作和思维方式,人力资源管理如何运用好互联网思维呢?以"绩效管理与激励创新"为主题的圆桌会议上,Jimmy Law、王娜、卢旭、侯正宇四位嘉宾对此作了深入探讨。 | Jimmy Law 王娜 卢旭 侯正宇 | 2015 | 职业2015，0，10： | 10 |
| 19 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 20 | Dynamic Contrast-Enhanced Perfusion MR Imaging Measurements of Endothelial Permeability: Differentiation between Atypical and Typical Meningiomas显示文摘BACKGROUND: AND PURPOSE: The measurement of relative cerebral blood volume (rCBV) and the volume transfer constant (K(trans)) by means of dynamic contrast-enhanced (DCE) perfusion MR imaging (pMRI) can be useful in characterizing brain tumors. The purpose of our study was to evaluate the utility of these measurements in differentiating typical meningiomas and atypical meningiomas. METHODS: Fifteen patients with pathologically confirmed typical meningiomas and seven with atypical meningiomas underwent conventional imaging and DCE pMRI before resection.rCBV measurements were calculated by using standard intravascular | Law M Zagzag D Golfinos JG Knopp EA Johnson G | 2003 | 中国神经肿瘤杂志2003，1，3： | 10 |
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