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| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms显示文摘 | Coutelle C Ward PJ Fleury B Quattrocchi P Chambrin H Iron A | 1997 | Hum Genet1997，99，3： | 3 |
| 3 | Evaluating rehabilitation interventionsin Parkinson's disease with functional MRI:a promising neuroprotective strategy显示文摘Parkinson’s disease(PD)is a progressive neurodegenerative disorder affecting approximately 10 million people worldwide(Planetta et al.,2014;Zigmond and Smeyne,2014).The principal clinical features of PD are bradykinesia,rigidity,tremor at rest and postural instability(Planetta et al.,2014).It is known that both PD itself and the use of anti-parkinson drugs are associated with several non-motor symptoms such as cognitive impairment,neuropsychiatric disturbances and sleep,autonomic,and sensory disorders(Park and Stacy, | Carlo Augusto Mallio Bruno Beomonte Zobel Carlo Cosimo Quattrocchi | 2015 | Neural Regeneration Research2015，10，5： | 2 |
| 4 | 深大活动断裂地球化学特征:以1783年2月5日意大利南部卡拉布里亚地震为例显示文摘1783年2~3月期间卡拉布里亚南部发生了5次大地震。大部分学者认为该次地震发震断层西倾、断层倾角较陡,断层在位于平原ESE部地区的结晶基岩上发生错动(Aspromonte断层)。而另外一些学者则认为发震断层为东倾且倾角较缓的隐伏断层(Gioia Tauro断层),和与其相邻的墨西拿海峡断裂相似。为了寻找发震断层方面的证据,1999-2000年期间,我们在Gioia Tauro平原共开展了4次地球化学调查。调查的目的是通过识别断层作用(或破裂),加强和深部水文循环有关的地球化学异常,得到关于地震成因方面的新的认识。深部流体特征用温度、盐度、碳总量与氡异常表征。共划分出三个主要的深部流体释放带:Nicotera-Galatro地区(沿着NW向Nicotera-Gioiosa-Jonica区域断裂线的Nicotera-Galatr0段);Gioia-Tauro与Seminara之间的NW-SE向小区域及Rosarno与Palmi之间的海岸线。其中Rosarno与Palmi之间的海岸线正好位于推测的Gioia Tauro断层上界。绝大部分地球化学异常发生在Rosamo周围,该地区位于Gioia Tauro断层与Nicotera-Gioiosa-Jonica区域断裂线的交汇部位。而在Aspromonte断层带没有发生明显的地下水侵蚀和压裂。基于以上发现我们提出了地球化学活动断裂带和地球化学交互作用断裂带的概念,从而进一步认识断层带的水力学特征及地壳中促使裂隙渗透性增强的断层作用机制。 | L Pizzino P Burrato F Quattrocchi G Valensise 张慧 | 2006 | 国际地震动态2006，，7： | 2 |
| 5 | MR differential diagnosis of acute deep grey matter pathology in paediatric patients显示文摘 | Carlo Cosimo Quattrocchi Daniela Longo Luciana Nogueira Delfino Yuri Errante Costanza Aiello Giuseppe Fariello Bruno Bernardi | 2013 | Pediatric Radiology2013，，： | 2 |
| 6 | Brainstem tegmental lesions in neonates with hypoxicischemic encephalopathy: Magnetic resonance diagnosis and clinical outcome显示文摘Lesions of the brainstem have been reported in the clinical scenarios of hypoxic-ischemic encephalopathy(HIE), although the prevalence of these lesions is probably underestimated. Neuropathologic studies have demonstrated brainstem involvement in severely asphyxiated infants as an indicator of poor outcome. Among survivors to HIE, the most frequent clinical complaints that may be predicted by brainstem lesions include feeding problems, speech, language and communication problems and visual impairments. Clinical series, including vascular and metabolic etiologies, have found selective involvement of the brainstem with the demonstration of symmetric bilateral columnar lesions of the tegmentum. The role of brainstem lesions in HIE is currently a matter of debate, especially when tegmental lesions are present in the absence of supratentorial lesions. Differential diagnosis of tegmental lesions in neonates and infants include congenital metabolic syndromes and drug-related processes. Brainstem injury with the presence of supratentorial lesions is a predictor of poor outcome and high rates of mortality and morbidity. Further investigation will be conducted to identify specific sites of the brainstem that are vulnerable to hypoxic-ischemic and toxic-metabolic insults. | Carlo Cosimo Quattrocchi Giuseppe Fariello Daniela Longo | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 7 | Effects of the immunomodulator, VGX-1027, in endotoxin- induced uveitis in Lewis rats显示文摘 | MANGANO K SARDESAI N Y QUATTROCCHI C | 2008 | Brit J Pharmacol2008，155，5： | 1 |
| 8 | Teriparatide: A review显示文摘 | Elaena Quattrocchi Helen Kourlas | 2004 | Clinical Therapeutics2004，，6： | 1 |
| 9 | Teriparatide:A review显示文摘 | Quattrocchi E Kourlas H | 2004 | Clin Ther2004，26，： | 1 |
| 10 | Magnetic resonance imaging differential diagnosis of brainstem lesions in children显示文摘Differential diagnosis of brainstem lesions,either isolated or in association with cerebellar and supra-tentorial lesions,can be challenging. Knowledge of the structural organization is crucial for the differential diagnosis and establishment of prognosis of pathologies with involvement of the brainstem. Familiarity with the location of the lesions in the brainstem is essential,especially in the pediatric population. Magnetic resonance imaging(MRI) is the most sensitive and specific imaging technique for diagnosing disorders of the posterior fossa and,particularly,the brainstem. High magnetic static field MRI allows detailed visualization of the morphology,signal intensity and metabolic content of the brainstem nuclei,together with visualization of the normal development and myelination. In this pictorial essay we review the brainstem pathology in pediatric patients and consider the MR imaging patterns that may help the radiologist to differentiate among vascular,toxico-metabolic,infectiveinflammatory,degenerative and neoplastic processes. Helpful MR tips can guide the differential diagnosis: These include the location and morphology of lesions,the brainstem vascularization territories,gray and white matter distribution and tissue selective vulnerability. | Carlo Cosimo Quattrocchi Yuri Errante Maria Camilla Rossi Espagnet Stefania Galassi Sabino Walter Della Sala Bruno Bernardi Giuseppe Fariello Daniela Longo | 2016 | World Journal of Radiology2016，8，1： | 1 |
| 11 | Primary cardiac rhabdomyosarcoma of the left atrium: an unusual presentation 显示文摘 | Castorino F Masiello P Quattrocchi E | 2000 | Tex Heart Inst J2000，27，2： | 1 |
| 12 | Geochemical Monitoring System II prototype (GMS II) installation at the 'Acqua Dife- sa' well, within the Etna region: first data during the 1999 volcanic crisis 显示文摘 | QUATTROCCHI F DI STEFANO G | 2000 | Journal of Volcanology And Geothermal Research2000，101，34： | 1 |
| 13 | Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience显示文摘 | L. Nogueira Delfino G. Fariello L. Lancella C. Marabotto L. Menchini R. Devito Y. Errante C. C. Quattrocchi D. Longo | 2012 | La radiologia medica2012，，： | 1 |
| 14 | Impairment of helper T-cell function and lymphokine actived killer crytotoxicity following severe head injury显示文摘 | Quattrocchi KB Frank EH Miller CH | 1991 | J neurosurg1991，75，： | 1 |
| 15 | Synthetic nanop- articles functionalized with biomimetic leukocyte membranes possess cell-like functions显示文摘 | Parodi A Quattrocchi N van de Ven AL | 2013 | Nat Nanotechnol2013，8，1： | 1 |
| 16 | Reelin is a serine protease of the extracellular matrix显示文摘 | Quattrocchi C C Wannenes F Persico A M | 2002 | J Biol Chem2002，277，1： | 1 |
| 17 | Impairment of help Tcell function and lymphokine actived killer crytotoxicity following severe head injury显示文摘 | Quattrocchi KB Frank EH Miller CH | 1991 | J Neurosurg1991，75，5： | 1 |
| 18 | Impairment of help T-cell function and lymphokine actived killer cytotoxicity following severe head injury显示文摘 | Quattrocchi KB Frank EH Miller CH | 1991 | J Neurosurg1991，75，： | 1 |
| 19 | Use of Adjuvants to Enhance the Immune Response Induced by a DNA Vaccine Against Bovine Herpesvirus-1显示文摘 | Di Giacomo S Quattrocchi V Zamorano P | 2015 | Viral Immunol2015，28，6： | 1 |
| 20 | Journal Club: possible role of the basal ganglia in poor reward sensitivity and apathy after stroke显示文摘 | Quattrocchi G Bestmann S | 2014 | Neurology2014，82，20： | 1 |
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