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287篇 您的检索式:作者名="Quake"
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15-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake 2017Cell Research2017,27,10:17
2Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region显示文摘Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials.Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu Yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino 2017World Journal of Gastroenterology2017,23,45:14
3The largest outbreak of hand; foot and mouth disease in Singapore in 2008: The role of enterovirus 71 and coxsackievirus A strains显示文摘Yan Wu Andrea Yeo M.C. Phoon E.L. Tan C.L. Poh S.H. Quak Vincent T.K. Chow 2010International Journal of Infectious Diseases2010,,:3
4Establishing enteral feeding in pretern infants with feeding intoletance: a randomized controlled study of low-dose erythromycin显示文摘QUAK S H 2003J Pediatr Gastroenterol Nutr2003,37,5:1
5Detection of aneuploidy with digital polymerase chain reaction显示文摘Fan HC Quake SR 2007Anal Chem2007,79,19:1
6Comorbid condition as a prognostic factor for complications in major surgery of the oral cavity and oropharynx with microvascular soft tissue reconstruction 显示文摘Borggreven PA Kuik D J Quak JJ 2003Head Neck2003,25,10:1
7Cholangitis in children with biliary atresia: health-care resource utilisation 显示文摘Lee JY Lim LT Quak SH 2014J Paediatr Child Health2014,50,3:1
8A nanoliter rotary device for polymerase chain reaction显示文摘Liu J Enzelberger M Quake S 2002Electrophoresis2002,23,10:1
9Development of a virus neutralisation test to detect antibodies against Schmallenberg virus and serological results in suspect and infected herds显示文摘Loeffen W Quak S De Boer-Luijtze E 2012Acta Vet Scand2012,54,:1
10A nanoliter rotary device for polymerase chain reaction显示文摘ENZELBERGER L J Quake S 2002Eleetrophoresis2002,23,10:1
11Digital PCR provides absolute quantitation of viral load for an occult RNA virus显示文摘White RA Quake SR Curr K 2012J Virol Methods2012,179,1:1
12Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism显示文摘Wolde M Sohne M Quak E 2004Arch Intern Med2004,164,15:1
13Decomposition and reconstruction algorithms for spline wavelets on a bounded interval 显示文摘Quak E Weyrich N 1994Applied and computational Hamonic Analysis1994,1,3:1
14Microfluidic integration on detector arrays for absorption and fluorescence micro-spectrometers 显示文摘Adams M L Enzelberger M Quake S 2003Sensors and Actuators2003,104,:1
15Trigonometric Wavalets for Hermite Interpolation 显示文摘Ewald Quak 1996Mathematics of Computation1996,65,214:1
16Microfluidics: fluid physics at the nanoliter scale 显示文摘Todd M Squires Stephen R Quake 2005Reviews of Modern Physics2005,77,3:1
17Rapid detection of Enterovirus 71 by real-time TaqMan RT-PCR显示文摘Eng Lee Tan Li Li Gaynor Yong Seng Hock Quak Wei Cheng Andrea Yeo Vincent Tak Kwong Chow Chit Laa Poh 2008Journal of Clinical Virology2008,,2:1
18Wavelets on a Bounded Interval显示文摘Chui C K Quak E 1992Numerical Methods of Approximation Theory1992,9,:1
19Evaluation of city logistics solutions with business model analysis 显示文摘QUAK H BALM S POSTHUMUS B 2014Procedia Social and Behavioral Sciences2014,125,3:1
20Cholangitis in children with biliary atresia: Health-care resource utilisation 显示文摘Lee JY Lira LT Quak SH 2014J Paediatr Child Heahh2014,50,3:1
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